Patents by Inventor Kent E.S. Matlack

Kent E.S. Matlack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast cells expressing amyloid beta and uses therefor
    Patent number: 10240160
    Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: March 26, 2019
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Kent E. S. Matlack, Susan L. Lindquist, Sebastian Treusch
  • YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR
    Publication number: 20180016588
    Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: May 4, 2017
    Publication date: January 18, 2018
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Kent E.S. Matlack, Susan L. Lindquist, Sebastian Treusch
  • Yeast cells expressing amyloid beta and uses therefor
    Patent number: 9677079
    Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: June 13, 2017
    Assignee: Whitehead Insititute for Biomedical Research
    Inventors: Kent E. S. Matlack, Susan L. Lindquist, Sebastian Treusch
  • YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR
    Publication number: 20130045483
    Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: June 29, 2012
    Publication date: February 21, 2013
    Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: SEBASTIAN TREUSCH, KENT E.S. MATLACK, SUSAN L. LINDQUIST
  • YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR
    Publication number: 20130022988
    Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: January 11, 2011
    Publication date: January 24, 2013
    Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Kent E.S. Matlack, Susan L. Lindquist