Patents by Inventor Kent Gates

Kent Gates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective Covalent Capture of a DNA Sequence
    Publication number: 20220333164
    Abstract: Provided herein are probes in which an Ap site of a probe strand can selectively cross-link with a 2?-deoxyguanosine (dG) of a target strand. Also provided for are methods of using such probes to generate and detect crosslinked molecules and methods of detecting disease associated genetic mutations.
    Type: Application
    Filed: August 10, 2020
    Publication date: October 20, 2022
    Inventors: Kent Gates, Li-Qun Gu, Maryam Imani Nejad, Xu Guo
  • Nucleic acid sequence and capture by formation of an abasic site-derived cross-link
    Patent number: 11034996
    Abstract: Disclosed herein is a method of covalently crosslinking DNA strands. In certain aspects, the method comprises incubating a hybridized, double-stranded DNA polynucleotide (dsDNA), comprising a probe strand that comprises an abasic (Ap) residue and an at least partially complementary target strand that comprises a 2?-deoxyadenosine (dA) residue, wherein incubation occurs under conditions that allow for a covalent crosslinking reaction to occur between the Ap residue in the probe strand and the dA residue in the target strand.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: June 15, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Kent Gates, Li-Qun Gu, Maryam Imani Nejad, Ruicheng Shi, Xinyue Zhang
  • Nucleic Acid Sequence and Capture by Formation of an Abasic Site-Derived Cross-Link
    Publication number: 20190271029
    Abstract: Disclosed herein is a method of covalently crosslinking DNA strands. In certain aspects, the method comprises incubating a hybridized, double-stranded DNA polynucleotide (dsDNA), comprising a probe strand that comprises an abasic (Ap) residue and an at least partially complementary target strand that comprises a 2?-deoxyadenosine (dA) residue, wherein incubation occurs under conditions that allow for a covalent crosslinking reaction to occur between the Ap residue in the probe strand and the dA residue in the target strand.
    Type: Application
    Filed: February 28, 2019
    Publication date: September 5, 2019
    Inventors: Kent Gates, Li-Qun Gu, Maryam Imani Nejad, Ruicheng Shi, Xinyue Zhang