Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: A vehicle includes a frame, a first support member including a first end, a second end and an intermediate portion supporting a first axle receiver, a first bellows mounted to the first end of the first support member, a second bellows mounted to the second end of the first support member, a second support member including a first end portion, a second end portion and an intermediate section supporting a second axle receiver, a third bellows mounted to the first end portion of the second support member, a fourth bellows mounted to the second end portion of the second support member, a first drive unit including a first transmission mounted to the first support member, and a first electric motor connected to the first transmission, and a second drive unit including a second transmission mounted to the second support member, and a second electric motor connected to the second transmission.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: A vehicle includes a frame, a first support member including a first end, a second end and an intermediate portion supporting a first axle receiver, a first bellows mounted to the first end of the first support member, a second bellows mounted to the second end of the first support member, a second support member including a first end portion, a second end portion and an intermediate section supporting a second axle receiver, a third bellows mounted to the first end portion of the second support member, a fourth bellows mounted to the second end portion of the second support member, a first drive unit including a first transmission mounted to the first support member, and a first electric motor connected to the first transmission, and a second drive unit including a second transmission mounted to the second support member, and a second electric motor connected to the second transmission.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: A pneumatic clutch actuator includes an actuator housing, a piston assembly, a bearing carrier, and a locking element. The piston assembly is disposed within the actuator housing and is movable between a first position and a second position. The piston assembly has a piston head, an elongate member extending from the piston head, and a lock ring coupled to the elongate member. The bearing carrier supports a bearing and is slidably disposed on a portion of the actuator housing. The locking element is operatively connected to the piston assembly and engages the bearing carrier to adjust a total length of the piston assembly as the piston assembly moves from the second position towards the first position to compensate for wear of the clutch assembly.

Abstract: A pneumatic clutch actuator includes an actuator housing, a piston assembly, a bearing carrier, and a locking element. The piston assembly is disposed within the actuator housing and is movable between a first position and a second position. The piston assembly has a piston head, an elongate member extending from the piston head, and a lock ring coupled to the elongate member. The bearing carrier supports a bearing and is slidably disposed on a portion of the actuator housing. The locking element is operatively connected to the piston assembly and engages the bearing carrier to adjust a total length of the piston assembly as the piston assembly moves from the second position towards the first position to compensate for wear of the clutch assembly.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: A position dependent valve device (10) for a control cylinder (12) includes at least one channel (24) formed in one of a wall of a cylinder housing (14) of the control cylinder (12) and a wall of a internal piston (20) disposed in the cylinder housing (14) and a seal (26) including a flexible member adapted to be disposed in a groove in the other one of the wall of the cylinder housing (14) and the wall of the piston (20), the seal (26) cooperating with the at least one channel (24) when the piston (20) is in a defined position to allow airflow past the piston (20) and cooperating with one of the cylinder housing (14) and the piston (20) when the piston (20) is in a position outside the defined position to prevent airflow past the piston (20).

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: Connection assembly (1) for connecting a first and second pipe end (201, 301) of pipes (200, 300). The pipe ends exhibit outwardly facing pipe locking profiles (203, 303). Locking segments (101) are distributed about the second pipe end (301) and have a connected (103) and a movable portion (105) with segment locking profiles (103a, 105a). The movable portion (105) is pivotable between an inward locking position and an outward free position. Among the pairs of facing locking profiles, comprising a first pair including the segment locking profile (103a) and facing pipe locking profile (303) of the second pipe end, and a second pair, at least one pair exhibits an inclined face (S1, S2, S3) which is misaligned a misalignment distance (M1, M2, M3) with respect to the facing inclined face (P1, P2, P3) of the profile with which it engages.

Abstract: A position dependent valve device (10) for a control cylinder (12) includes at least one channel (24) formed in one of a wall of a cylinder housing (14) of the control cylinder (12) and a wall of a internal piston (20) disposed in the cylinder housing (14) and a seal (26) including a flexible member adapted to be disposed in a groove in the other one of the wall of the cylinder housing (14) and the wall of the piston (20), the seal (26) cooperating with the at least one channel (24) when the piston (20) is in a defined position to allow airflow past the piston (20) and cooperating with one of the cylinder housing (14) and the piston (20) when the piston (20) is in a position outside the defined position to prevent airflow past the piston (20).

Abstract: An aqueous carbon dioxide-absorbent solution comprising at least one alkanolamine and at least one quaternary ammonium salt is disclosed. A method of recovering carbon dioxide from a carbon dioxide-containing gaseous mixture and a method of reducing metal corrosion in an alkanolamine-based exhaust gas treating process are also disclosed.

Abstract: The present invention is a preservative formulation which includes a combination of at least two (2) compounds having bactericidal and/or fungicidal properties wherein the at least two (2) compounds is selected from the group consisting of methylisothiazolinone/piroctone olamine; caprylyl glycol/dehydroacetic acid; undecanol/dehydroacetic acid and lauryl alcohol/sorbic acid. The invention also includes preparations including such combination as well as a method of using the combination to reduce bacterial and fungal load of preparations.

Abstract: The invention provides a method for preventing discoloration of pyrithione-containing materials, in particular plastic materials or other material such as paints, coatings, adhesives or textiles which are exposed to an outdoor environment. The method is likewise suited for preventing discoloration of other pyrithione-containing materials such as personal care compositions like shampoos. A discoloration inhibitor that includes dehydroacetic acid or a salt thereof is added to the pyrithione-containing material. The discoloration is prevented without the addition of a cyclic organic phosphoric acid ester or an organic phosphite. Use of the discoloration inhibitor does not interfere with the antimicrobial effect of the pyrithione.

Abstract: A system is provided for use and handling a medical liquid (e.g. hazardous drugs) that includes a transfer adapter having a port rotatably interconnectable to a male luer fitting of a needleless syringe or infusion tubing line port, and a patient connector having a port rotatable interconnectable to a female luer fitting of an intravascular catheter access port. Ports of the transfer adapter and patient connector are interconnectable to automatically define a closed fluid passageway. A vial adapter and/or a reservoir adapter may be provided for selective interconnection to the transfer adapter wherein a second closed fluid passageway and/or a third closed fluid passageway are automatically defined upon interconnection with the transfer adapter.

Abstract: Connection assembly (I) for connecting a first and second pipe end (201, 301) of pipes (200, 300). The pipe ends exhibit outwardly facing pipe locking profiles (203, 303). Locking segments (101) are distributed about the second pipe end (301) and have a connected (103) and a movable portion (105) with segment locking profiles (103a, 105a). The movable portion (105) is pivotable between an inward locking position and an outward free position. Among the pairs of facing locking profiles, comprising a first pair including the segment locking profile (103a) and facing pipe locking profile (303) of the second pipe end, and a second pair, at least one pair exhibits an inclined face (S1, S2, S3) which is misaligned a misalignment distance (M1, M2, M3) with respect to the facing inclined face (P1, P2, P3) of the profile with which it engages.

Abstract: Connection assembly (1) for connecting a first and second pipe end (201, 301) of pipes (200, 300). The pipe ends exhibit outwardly facing pipe locking profiles (203, 303). Locking segments (101) are distributed about the second pipe end (301) and have a connected (103) and a movable portion (105) with segment locking profiles (103a, 105a). The movable portion (105) is pivotable between an inward locking position and an outward free position. Among the pairs of facing locking profiles, comprising a first pair including the segment locking profile (103a) and facing pipe locking profile (303) of the second pipe end, and a second pair, at least one pair exhibits an inclined face (S1, S2, S3) which is misaligned a misalignment distance (M1, M2, M3) with respect to the facing inclined face (P1, P2, P3) of the profile with which it engages.