Abstract: A backpack frame system having a slotted frame configured to be detachably and interchangeably connected with a backpack is provided. The frame can include a plurality of generally uniformly spaced-apart slats extending between at least two upright members or cross members. Slots are defined between the slats, which are adapted for connection with an attachment system such that one or more objects or cargo may be hung from or otherwise secured to the frame. A looping system is provided for connecting the frame to the backpack. The backpack may be provided with a looping system comprising first and second sets of loops that can be interconnected by a connector and encircle a portion of the frame, such as an upright member, thereby connecting the frame to the backpack.