Abstract: Disclosed is a method for detecting an anti-SARS-CoV-2 antibody, the method comprising: detecting an antibody against a chimeric protein comprising an amino acid sequence of a receptor binding region of SARS-CoV-2 and an amino acid sequence of a receptor binding region of a coronavirus belonging to Nobecovirus subgenus in a specimen obtained from a subject using the chimeric protein, the chimeric protein being a protein represented by (i) a protein comprising an amino acid sequence set forth in SEQ ID NO: 1 or 2; or (ii) a protein comprising an amino acid sequence having 80% or more of identity to the amino acid sequence set forth in SEQ ID NO: 1 or 2 and binding to an antibody that recognizes the receptor binding region of SARS-CoV-2.

Abstract: Disclosed is a method for determining sensitivity to a CDK4/6 inhibitor, comprising the steps of: comparing a value based on activity of at least one CDK selected from CDK4 and CDK6 in a sample collected from a subject, with a threshold level corresponding to the CDK, and determining that the subject is insensitive to the CDK4/6 inhibitor when the value based on the CDK activity is less than the threshold level.

Abstract: Provided is a laser scattered light measuring device capable of easily confirming the safety of laser scattered light to a human body. The laser scattered light measuring device includes a light receiving unit, a calculation unit, and a display unit. The light receiving unit receives laser scattered light generated by irradiating an object with laser light and detects intensity of the laser scattered light. The calculation unit compares the intensity of the laser scattered light received by the light receiving unit with a predetermined threshold value and calculates a degree of risk of the laser scattered light to a human body based on a comparison result. The display unit displays the degree of risk calculated by the calculation unit.

Abstract: Disclosed is a method for acquiring information on exacerbation risk of COVID-19, comprising measuring IgM antibody against S antigen of SARS-CoV-2 contained in a specimen collected from a subject infected with SARS-CoV-2 or a subject suspected of suffering from COVID-19, wherein a value obtained by the measurement of IgM antibody serves as an index of exacerbation risk of COVID-19 of the subject.

Abstract: Disclosed is a cyclin-dependent kinase substrate including a polypeptide that contains an amino acid sequence represented by formula (1): R1—P (wherein R1 represents a serine residue or a threonine residue, P represents a proline residue, “—” represents a single bond, and the left side represents the N-terminal side), and satisfies the following (a1) and/or (b1): (a1) the second amino acid residue counting from the proline residue toward the N-terminal side in the formula (1) is an aromatic amino acid residue, and/or (b1) at least two amino acid residues from the proline residue toward the C-terminal side in the formula (1) are acidic amino acid residues.

Abstract: Disclosed is a method for determining sensitivity to a CDK4/6 inhibitor, comprising the steps of: comparing a value based on activity of at least one CDK selected from CDK4 and CDK6 in a sample collected from a subject, with a threshold level corresponding to the CDK, and determining that the subject is insensitive to the CDK4/6 inhibitor when the value based on the CDK activity is less than the threshold level.

Abstract: Disclosed is a test instrument for measuring an analyte in a liquid sample by a noble metal colloid aggregation measurement method. The test instrument involves a reaction chamber in which at least the liquid sample is to be reacted with a reagent, wherein the reagent is adhered on at least a part of a surface constituting the reaction chamber in a dried state, and the reagent enables the measurement of the analyte by a noble metal colloid aggregation measurement method.

Abstract: The purpose of the present invention is to provide a method for separating and concentrating a target substance as an alternative to existing cationic polymers, and a kit for implementing this method.

Abstract: The purpose of the present invention is to provide a monoclonal antibody that is useful in specifically assaying tartrate resistant acid phosphatase 5b (TRACP-5b). A hybridoma producing a monoclonal antibody against TRACP-5b, said monoclonal antibody showing higher reactivity with TRACP-5b than with tartrate resistant acid phosphatase 5a (TRACP-5a) and, therefore, being specific to TRACP-5b, is obtained by cell fusion using, as an antigen, human recombinant TRACP-5b purified from silkworm silk gland. By using this monoclonal antibody, TRACP-5b in a specimen can be highly sensitively and specifically detected.

Abstract: Disclosed is a cyclin-dependent kinase substrate including a polypeptide that contains an amino acid sequence represented by formula (1): R1-P (wherein R1 represents a serine residue or a threonine residue, P represents a proline residue, “—” represents a single bond, and the left side represents the N-terminal side), and satisfies the following (a1) and/or (b1): (a1) the second amino acid residue counting from the proline residue toward the N-terminal side in the formula (1) is an aromatic amino acid residue, and/or (b1) at least two amino acid residues from the proline residue toward the C-terminal side in the formula (1) are acidic amino acid residues.

Abstract: Disclosed is a cartridge for sample analysis, including a cartridge base body having, formed therein, a chamber configured to store a liquid containing a test substance, and a storage portion which is connectable with the chamber and is configured to store a liquid reagent to be supplied to the chamber, carrier particles immobilized onto an inner wall of the chamber, a first liquid reagent stored in the storage portion, and a first capture substance that specifically binds to the test substance. The carrier particles are immobilized onto the inner wall by means of a solid mixture containing sugar and protein.

Abstract: The purpose of the present invention is to provide a monoclonal antibody that is useful in specifically assaying tartrate resistant acid phosphatase 5b (TRACP-5b). A hybridoma producing a monoclonal antibody against TRACP-5b, said monoclonal antibody showing higher reactivity with TRACP-5b than with tartrate resistant acid phosphatase 5a (TRACP-5a) and, therefore, being specific to TRACP-5b, is obtained by cell fusion using, as an antigen, human recombinant TRACP-5b purified from silkworm silk gland. By using this monoclonal antibody, TRACP-5b in a specimen can be highly sensitively and specifically detected.

Abstract: The purpose of the present invention is to provide a method for separating and concentrating a target substance as an alternative to existing cationic polymers, and a kit for implementing this method.

Abstract: An autoantibody against Ku86 can be measured by reacting the autoantibody contained in a sample with a Ku86 antigen (which serves as a reagent) to produce an immune complex of the autoantibody and the Ku86 antigen and measuring the immune complex using a labeled anti-human immunoglobulin antibody. The measurement of the autoantibody enables the determination of primary hepatocellular carcinoma.

Abstract: In a synthetic resin lens, a thermoplastic resin is caused to contain a blue pigment having the lowest value for light transmittance in 570-610 nm, and a pink pigment that, among blue light of 380-500 nm, has the highest value for light transmittance in 400-440 nm and the lowest value for light transmittance in 480-520 nm, resulting in a transparent achromatic lens having a lowest value for light transmittance in 570-610 nm. As a result, provided is a synthetic resin lens that, when used in sunglasses, corrective glasses, shields, or the like, has favorable contrast (visibility), few marked color changes when installed, and a natural color.

Abstract: Disclosed is an immunoassay method whereby a 5.9 kDa peptide which results from the degradation of the ?-E chain and ? chain of human fibrinogens and which is used as a peptide marker for diagnosing hepatic disease can be specifically assayed in a biological sample containing contaminating peptides by bringing antibodies that recognize the N terminal of said peptide marker and antibodies that recognize the C terminal of said peptide marker into contact with said peptide marker, forming immune complexes of said peptide marker and the two antibodies, and immunoassaying the obtained immune complexes.

Abstract: A marker for detecting pancreatic cancer, said marker comprising a glycoprotein C4BPA or PIGR, whereby a pancreatic cancer patient can be distinguished from a chronic pancreatitis patient or a normal subject and thus specifically diagnosed. Also, the marker is usable in monitoring the postoperative prognosis of a pancreatic cancer patient. When the aforesaid marker is used in combination with another pancreatic cancer marker such as CA19-9, furthermore, a pancreatic cancer patient can be distinguished from a chronic pancreatitis patient or a normal subject and diagnosed more specifically.

Abstract: In a synthetic resin lens, a thermoplastic resin is caused to contain a blue pigment having the lowest value for light transmittance in 570-610 nm, and a pink pigment that, among blue light of 380-500 nm, has the highest value for light transmittance in 400-440 nm and the lowest value for light transmittance in 480-520 nm, resulting in a transparent achromatic lens having a lowest value for light transmittance in 570-610 nm. As a result, provided is a synthetic resin lens that, when used in sunglasses, corrective glasses, shields, or the like, has favorable contrast (visibility), few marked color changes when installed, and a natural color.

Abstract: A transponder for performing bidirectional conversion between a client-side signal used for communication to a client device and a transmission path-side signal used for communication to a transmission path, the transponder comprising: a client-side interface for inputting/outputting the client-side signal; a transmission path-side interface for inputting/outputting the transmission path-side signal; a connection determining unit for determining which of the another client-side interface and the client device is coupled to the client-side interface; and a transmission signal generating unit for outputting, in a case where a state signal indicating a state on a transmission path side is input to the transmission path-side interface, a transmission signal indicating that the state signal has been input, from the client-side interface, wherein: the transmission signal generating unit changes a form of the transmission signal to be output from the client-side interface, based on a determination result obtained by

Abstract: An embodiment of the invention is an optical communication system including: a plurality of interface boards which transmit and receive optical signals to and from interface boards facing the plurality of interface boards; and a monitoring control device which monitors states of the plurality of interface boards. A first interface board of the plurality of interface boards includes: a replacement unit capable of monitoring the states of the plurality of interface boards on behalf of the monitoring control device and independently receiving supply of power; and a control unit configured to start the replacement unit in a case where a fault occurs in the monitoring control device and stop or halt the replacement unit in a case where there is no fault in the monitoring control device.