Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Abstract: A medium transport device includes a transport belt that is disposed in such a manner as to face an image holding unit holding an image and that is capable of moving circularly so as to transport a medium, a first stretching roller that stretches a portion of the transport belt and that is disposed in such a manner as to face the image holding unit, the first stretching roller being configured to transport the medium by nipping the medium between the image holding unit and the transport belt and configured to transfer the image held by the image holding unit onto the medium, a second stretching roller that stretches a portion of the transport belt that is located downstream from the portion of the transport belt stretched by the first stretching roller in a transport direction of the medium, a contact adjusting unit that causes a second end of the first stretching roller in an axial direction of the first stretching roller to swing while a first end of the first stretching roller serves as a fulcrum and adjus

Abstract: A method for manufacturing a multilayered-reflective-film-provided substrate including a substrate and a multilayer reflective film that reflects EUV light on the substrate, the method includes performing a first defect inspection on the multilayered-reflective-film-provided substrate with a first wavelength to acquire first defect information, performing a second defect inspection on the multilayered-reflective-film-provided substrate with a second wavelength different from the first wavelength to acquire second defect information, and determining whether there is an unmatching defect and a matching defect by comparing the first defect information with the second defect information to acquire third defect information.

Abstract: A medium transport device includes a transport member and a guide member. The transport member supports and transports a medium. The guide member is shifted from the transport member in a width direction of the medium to guide the medium. The guide member includes contact portions that come into contact with the medium. The contact portions are spaced apart from one another in a transport direction of the medium.

Abstract: An image forming apparatus includes a first unit, a second unit, a first adjusting member, and a second adjusting member. The first unit includes an endless first belt member and a first rotating member that rotates while supporting the first belt member. The second unit includes a rotatable second rotating member that opposes the first rotating member with the first belt member interposed therebetween. The first adjusting member is disposed on either one of the first unit and the second unit to adjust a load between the first rotating member and the second rotating member. The second adjusting member is disposed on the other one of the first unit and the second unit to adjust parallelism between the first rotating member and the second rotating member.

Abstract: An image forming apparatus includes a first unit, a second unit, a first adjusting member, and a second adjusting member. The first unit includes an endless first belt member and a first rotating member that rotates while supporting the first belt member. The second unit includes a rotatable second rotating member that opposes the first rotating member with the first belt member interposed therebetween. The first adjusting member is disposed on either one of the first unit and the second unit to adjust a load between the first rotating member and the second rotating member. The second adjusting member is disposed on the other one of the first unit and the second unit to adjust parallelism between the first rotating member and the second rotating member.

Abstract: A medium transport device includes a transport belt that is disposed in such a manner as to face an image holding unit holding an image and that is capable of moving circularly so as to transport a medium, a first stretching roller that stretches a portion of the transport belt and that is disposed in such a manner as to face the image holding unit, the first stretching roller being configured to transport the medium by nipping the medium between the image holding unit and the transport belt and configured to transfer the image held by the image holding unit onto the medium, a second stretching roller that stretches a portion of the transport belt that is located downstream from the portion of the transport belt stretched by the first stretching roller in a transport direction of the medium, a contact adjusting unit that causes a second end of the first stretching roller in an axial direction of the first stretching roller to swing while a first end of the first stretching roller serves as a fulcrum and adjus

Abstract: A medium transport device includes a transport member and a guide member. The transport member supports and transports a medium. The guide member is shifted from the transport member in a width direction of the medium to guide the medium. The guide member includes contact portions that come into contact with the medium. The contact portions are spaced apart from one another in a transport direction of the medium.

Abstract: A transfer device includes a transfer unit and an adjustment unit. The transfer unit includes a transfer belt and a transfer roller. The transfer belt is wound around a rotating winding roller to circulate. An image is to be formed on the transfer belt. The transfer roller is disposed on an opposite side of the winding roller across the transfer belt. The transfer roller is configured to transfer the image on the transfer belt to a recording medium. The adjustment unit is configured to change an axial direction of the transfer roller to adjust parallelism between an axis of the transfer roller and an axis of the winding roller.

Abstract: A transfer device includes a transfer unit and an adjustment unit The transfer unit includes a transfer belt and a transfer roller. The transfer belt is wound around a rotating winding roller to circulate. An image is to be formed on the transfer belt. The transfer roller is disposed on an opposite side of the winding roller across the transfer belt. The transfer roller is configured to transfer the image on the transfer belt to a recording medium. The adjustment unit is configured to change an axial direction of the transfer roller to adjust parallelism between an axis of the transfer roller and an axis of the winding roller.

Abstract: A flywheel includes a rotation shaft, a flywheel body, and a protruding body. A first end of the rotation shaft is supported by a rotating body. The flywheel body is provided at a second end of the rotation shaft and rotates together with the rotation shaft. The protruding body protrudes from a surface at a rotating-body side of the flywheel body and extends in a circumferential direction of the rotation shaft.

Abstract: A flywheel includes a rotation shaft, a flywheel body, and a protruding body. A first end of the rotation shaft is supported by a rotating body. The flywheel body is provided at a second end of the rotation shaft and rotates together with the rotation shaft. The protruding body protrudes from a surface at a rotating-body side of the flywheel body and extends in a circumferential direction of the rotation shaft.

Abstract: Provided is a transfer device including a primary transfer roller that selectively takes a contact position where an intermediate transfer belt is brought into contact with an image holding member, and a separation position where the intermediate transfer belt is separated from the image holding member, a tension applying roller on which the intermediate transfer belt is wound thereon together with a driving roller and which is urged in a direction receding from the driving roller, and a relaxing member that is attached to a shaft portion of the tension applying roller, is urged by an urging unit in a direction approaching the driving roller, and relaxes an urging force of the tension applying roller in a direction receding from the driving roller when the primary transfer roller is at the separation position.

Abstract: Provided is a transfer device including a primary transfer roller that selectively takes a contact position where an intermediate transfer belt is brought into contact with an image holding member, and a separation position where the intermediate transfer belt is separated from the image holding member, a tension applying roller on which the intermediate transfer belt is wound thereon together with a driving roller and which is urged in a direction receding from the driving roller, and a relaxing member that is attached to a shaft portion of the tension applying roller, is urged by an urging unit in a direction approaching the driving roller, and relaxes an urging force of the tension applying roller in a direction receding from the driving roller when the primary transfer roller is at the separation position.

Abstract: A ceramics sintered body improved in corrosion resistance to a molten metal and a method for producing such a ceramics sintered body. The ceramics sintered body includes boron nitride, titanium diboride, a calcium compound and titanium nitride and having a relative density of 92% or more, wherein the content of the calcium compound in terms of CaO is from 0.05 to 0.8% by weight, and a peak intensity by X-ray diffraction of the (200) plane derived from titanium nitride is from 0.06 to 0.15 relative to a peak intensity of the (002) plane of BN. Further, a method for producing a ceramics sintered body, which is applicable to the ceramics sintered body, and an exothermic body for metal vapor deposition constituted by the ceramics sintered body are also disclosed.

Abstract: A metal evaporation boat having improved wettability to a molten metal and having a prolonged life, and a method for evaporating a metal employing it. A metal evaporation heating element characterized by having one or more grooves in a direction not in parallel with a current direction, on an upper surface of a ceramic sintered body comprising titanium diboride (TiB2) and/or zirconium diboride (ZrB2), and boron nitride (BN). It is preferred that the direction not in parallel with the current collection is from 20 to 160° C. to the current direction, that the ceramic sintered body has a cavity and the groove is formed on the bottom surface thereof, and that a predetermined pattern is drawn by a plurality of grooves on the upper surface of the ceramic sintered body and/or on the upper surface of the cavity.

Abstract: A ceramics sintered body improved in corrosion resistance to a molten metal and a method for producing such a ceramics sintered body. The ceramics sintered body includes boron nitride, titanium diboride, a calcium compound and titanium nitride and having a relative density of 92% or more, wherein the content of the calcium compound in terms of CaO is from 0.05 to 0.8% by weight, and a peak intensity by X-ray diffraction of the (200) plane derived from titanium nitride is from 0.06 to 0.15 relative to a peak intensity of the (002) plane of BN. Further, a method for producing a ceramics sintered body, which is applicable to the ceramics sintered body, and an exothermic body for metal vapor deposition constituted by the ceramics sintered body are also disclosed.

Abstract: An optical circuit assembly is composed of a board for mounting an optical circuit element, an optical adapter that connects an optical fiber cable to the optical circuit element, and an adapter supporting member which movably supports the optical adapter. The adapter supporting member allows the optical adapter to move between first and second positions. The first position is located substantially at an edge of the board, and the second position is located above the board away from the edge.

Abstract: An optical circuit assembly is composed of a board for mounting an optical circuit element, an optical adapter that connects an optical fiber cable to the optical circuit element, and an adapter supporting member which movably supports the optical adapter. The adapter supporting member allows the optical adapter to move between first and second positions. The first position is located substantially at an edge of the board, and the second position is located above the board away from the edge.