Abstract: The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.

Abstract: The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.

Abstract: 1) A graft material for nerve regeneration characterizing by comprising collagen-based materials containing collagen having an orientation. 2) A method for producing a graft material for nerve regeneration comprising a step of immersing the collagen-based materials containing collagen having an orientation in a solution containing a collagen-binding site-containing growth factor comprising a receptor agonist peptide and a collagen-binding peptide and binding the collagen-binding site-containing growth factor to the collagen. 3) A kit for producing a graft material for nerve regeneration characterized by comprising collagen-based materials containing collagen having an orientation, and a collagen-binding site-containing growth factor comprising a receptor agonist peptide and a collagen-binding peptide.

Abstract: Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.

Abstract: Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.

Abstract: A mixer circuit includes: a mixer circuit including a first transistor pair to output a first differential input signal and a second transistor pair to output a second differential input signal by inversing the first differential signal; a local signal supply circuit to supply a pair of local signals to gates of the first transistor pair and the second transistor pair; an operational amplifier including an input pair coupled to an output pair of the mixer circuit and an output pair coupled to the input pair via feedback resistors, the operational amplifier to amplify the first differential input signal and output a differential output signal; a common mode feedback circuit to control a center voltage of the differential output signal so that the center voltage maintains a common voltage; and a common voltage generator circuit to generate the common voltage according to an amplitude of the local signal.

Abstract: A mixer circuit includes: a mixer circuit including a first transistor pair to output a first differential input signal and a second transistor pair to output a second differential input signal by inversing the first differential signal; a local signal supply circuit to supply a pair of local signals to gates of the first transistor pair and the second transistor pair; an operational amplifier including an input pair coupled to an output pair of the mixer circuit and an output pair coupled to the input pair via feedback resistors, the operational amplifier to amplify the first differential input signal and output a differential output signal; a common mode feedback circuit to control a center voltage of the differential output signal so that the center voltage maintains a common voltage; and a common voltage generator circuit to generate the common voltage according to an amplitude of the local signal.