Abstract: There is disclosed a high containment device, apparatus or system for withdrawing sample material from process or manufacturing equipment with substantially no leakage of the sample material to the external environment and which is of syringe-type construction, thus preventing possible contamination of such environment or workers operating processing and/or production equipment in such a situation, especially where hazardous materials are involved. The high containment device, apparatus or system disclosed is used in combination with process or manufacturing equipment thus providing a system which results in the prevention of leakage of possible hazardous material to the environment and possible contamination of equipment operators thereby.

Abstract: Apparatus is provided for charging a bioreactor with feed material through a sight port in the bioreactor vessel wall without compromising sterility of the material or the vessel or releasing organisms from the vessel to the surrounding atmosphere.