Patents by Inventor Kenward S. Vaughan

Kenward S. Vaughan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-methoxy-4-hydroxyphenylglycol fluorescence polarization immunoassay and conjugates
    Patent number: 5372949
    Abstract: The present invention is directed to a fluorescence polarization immunoassay for determining the 3-methoxy-4-hydroxyphenylglycol content in body fluids, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a sample containing antiserum and tracer.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: December 13, 1994
    Assignee: Abbott Laboratories
    Inventors: Christine H. Zeitvogel, Maciej B. Adamczyk, David A. Betebenner, Kenward S. Vaughan
  • 3-methoxy-4-hydroxyphenylglycol fluorescence polarization immunoassay
    Patent number: 5145791
    Abstract: The present invention is directed to a fluoroescence polarization immunoassay for determining the 3-methoxy-4-hydroxyphenylglycol content in body fluids, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a sample containing antiserum and tracer.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: September 8, 1992
    Assignee: Abbott Laboratories
    Inventors: Christine H. Zeitvogel, Maciej B. Adamczyk, David A. Betebenner, Kenward S. Vaughan
  • Fluorescence polymerization immunoassay for amphetamine/methamphetamine
    Patent number: 4952336
    Abstract: This disclosure relates to a method and reagents for determining amphetamine and methamphetamine in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as .beta.-hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4.0 to about 7.5 without adjustment to an alkaline pH.
    Type: Grant
    Filed: July 22, 1989
    Date of Patent: August 28, 1990
    Assignee: Abbott Laboratories
    Inventors: Paul J. Brynes, Cynthia M. Molina, Janis A. Martinus, Kenward S. Vaughan, Catherine M. Smith
  • Fluorescence polarization immunoassay for amphetamine/methamphetamine
    Patent number: 4868132
    Abstract: This disclosure relates to a method and reagents for determining amphetamine and methamphetamine in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as .beta.-hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4.0 to about 7.5 without adjustment to an alkaline pH.
    Type: Grant
    Filed: February 3, 1987
    Date of Patent: September 19, 1989
    Assignee: Abbott Laboratories
    Inventors: Paul J. Byrnes, Cynthia M. Molina, Janis A. Martinus, Kenward S. Vaughan, Catherine M. Smith