Patents by Inventor Kenya Ishida

Kenya Ishida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240197610
    Abstract: A ceramide growth promoting agent includes ceramides represented by the general formula (1), in which, in the general formula (1), R1 represents a monovalent hydrocarbon group having 13 to 21 carbon atoms which may have a hydroxyl group or a double bond, and Z represents an acyl group having 14 to 24 carbon atoms which may have a hydrogen atom, an acetyl group or a hydroxyl group:
    Type: Application
    Filed: March 8, 2021
    Publication date: June 20, 2024
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kenya ISHIDA, Hisashi MIHARA, Kyungho PARK, Yoshikazu UCHIDA
  • Publication number: 20220378689
    Abstract: The present invention relates to a fragrance or flavor composition comprising a fragrance or flavor component acting on at least one olfactory receptor polypeptide selected from the group consisting of (a) OR2C1 and OR4Q3, and (b) polypeptides which comprise an amino acid sequence sharing an identity of at least 80% with the amino acid sequence of any of the polypeptides in (a) and which are responsive to at least one offensive odor-causing substance selected from the group consisting of trans-2-nonenal, trans-2-octenal, 1-octen-3-one, 1,5-octadien-3-one, 1-octen-3-ol and 1,5-octadien-3-ol to suppress the response intensity of the olfactory receptor polypeptide(s) to at least one of the offensive odor-causing substances, and also relates to a product comprising this fragrance or flavor composition and a method for suppressing offensive odors.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 1, 2022
    Applicant: Takasago International Corporation
    Inventors: Hisashi MIHARA, Yukari KUWAHARA, Azusa MIKI, Tsuyoshi KOBAYASHI, Kenya ISHIDA
  • Patent number: 11464720
    Abstract: This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: October 11, 2022
    Assignees: MANDOM CORPORATION, TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Masayuki Takaishi, Fumitaka Fujita, Hironori Shimizu, Shu Sakuyama, Kenya Ishida, Kenji Maruyama
  • Publication number: 20220031901
    Abstract: The present invention relates to a fragrance composition containing a fragrance component which suppresses response strength of at least one olfactory receptor polypeptide, which is selected from the group consisting of OR2L3 and polypeptides that comprise an amino acid sequence having at least 80% identity to an amino acid sequence of OR2L3 and are responsive to an unpleasant odor-causing substance, to the unpleasant odor-causing substance. According to a preferred embodiment of the present invention, an unpleasant odor masking composition containing, as active components, at least one antagonist against an olfactory receptor OR2L3 and a specific component among fragrances which do not exert the effect of suppressing the response of OR2L3, is provided. According to a preferred embodiment of the present invention, unpleasantness caused by at least one unpleasant odor selected from the group consisting of fecal odor, body odor, tobacco odor, breath odor and musty odor can be reduced.
    Type: Application
    Filed: July 27, 2021
    Publication date: February 3, 2022
    Applicant: Takasago International Corporation
    Inventors: Hisashi MIHARA, Yukari KUWAHARA, Masato MURAI, Tsuyoshi KOBAYASHI, Kenya ISHIDA
  • Publication number: 20200022889
    Abstract: This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.
    Type: Application
    Filed: March 13, 2018
    Publication date: January 23, 2020
    Applicants: MANDOM CORPORATION, TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Masayuki Takaishi, Fumitaka Fujita, Hironori Shimizu, Shu Sakuyama, Kenya Ishida, Kenji Maruyama
  • Patent number: 9975831
    Abstract: An object of the present invention is to provide a method for producing an ether compound easily in a small number of steps at lower costs in high yields. The present invention relates to a method in which the ether compound represented by the general formula (1) is produced by reacting the specific carbonyl compound specified in the general formula (2) and the specific dialkoxy compound specified in the general formula (3) with hydrogen in the presence of a hydrogenation catalyst and an acidic substance to perform hydrogenation.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: May 22, 2018
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Yasuhiro Komatsuki, Kenya Ishida, Kenji Yagi
  • Patent number: 9486395
    Abstract: The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)—N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: November 8, 2016
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Louis Lombardo, Michael E. Lankin, Kenya Ishida, Shigeru Tanaka, Hideo Ujihara, Kenji Yagi, Jennifer B. Tartaglia, Carter B. Green, Amrit S. Mankoo
  • Patent number: 9233916
    Abstract: The present invention provides a method for producing a nitrile represented by general formula (1) (in the formula, R denotes an optionally substituted alkyl group, alkenyl group, dienyl group, aralkyl group or aryl group having a total of 3-20 carbon atoms), and the method includes heating an aldoxime represented by general formula (2) (in the formula, R denotes the same groups as those mentioned above) at 80-250° C. in the presence of an alkali metal or alkaline earth metal salt of phosphoric acid (catalyst A) and distilling off water generated as the reaction progresses to outside the reaction system.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: January 12, 2016
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kenji Yagi, Kenya Ishida
  • Publication number: 20150266847
    Abstract: The present invention provides a novel macrocyclic compound exhibiting superior odor qualities and having a musk-like aroma, a method for producing the same, and a novel flavor or fragrance composition, and food products or beverages, fragrances or cosmetics, daily necessities or household goods and oral products using the novel macrocyclic compound. The invention relates to a compound represented by the formula (1), wherein each of wavy lines represents at least one of an E-configuration of C?C double bond and an Z-configuration of C?C double bond; m represents an integer of 0 to 10; and n represents an integer of 1 to 11, and n represents an integer of 1 to 11 when m is 0 to 4 or 6 to 10, and n is an integer of 1 or 3 to 11 when m is 5.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Teruhiko Inaba, Kenya Ishida
  • Patent number: 9085545
    Abstract: The present invention provides a novel macrocyclic compound exhibiting superior odor qualities and having a musk-like aroma, a method for producing the same, and a novel flavor or fragrance composition, and food products or beverages, fragrances or cosmetics, daily necessities or household goods and oral products using the novel macrocyclic compound. The invention relates to a compound represented by the formula (1), wherein each of wavy lines represents at least one of an E-configuration of C?C double bond and an Z-configuration of C?C double bond; m represents an integer of 0 to 10; and n represents an integer of 1 to 11, and n represents an integer of 1 to 11 when m is 0 to 4 or 6 to 10, and n is an integer of 1 or 3 to 11 when m is 5.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: July 21, 2015
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Teruhiko Inaba, Kenya Ishida
  • Patent number: 9079826
    Abstract: Provided is a method for producing an optically active ceramide by an N-acylation (amidation) reaction of an optically active aminodiol, wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely, provided is a method for producing a high-purity ceramide that has high diastereo purity with high yield. A high-purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1-5 carbon atoms of an aliphatic carboxylic acid having 12-24 carbon atoms, said aliphatic carboxylic acid optionally having a hydroxyl group, in a hydrocarbon solvent having 5-10 carbon atoms; and a step wherein an alcohol having 1-3 carbon atoms is added into the reaction mixture obtained in the preceding step, thereby causing crystals to precipitate.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: July 14, 2015
    Assignee: Takasago International Corporation
    Inventors: Kenya Ishida, Kenji Yagi
  • Publication number: 20150148558
    Abstract: The present invention provides a method for producing a nitrile represented by general formula (1) (in the formula, R denotes an optionally substituted alkyl group, alkenyl group, dienyl group, aralkyl group or aryl group having a total of 3-20 carbon atoms), and the method includes heating an aldoxime represented by general formula (2) (in the formula, R denotes the same groups as those mentioned above) at 80-250° C. in the presence of an alkali metal or alkaline earth metal salt of phosphoric acid (catalyst A) and distilling off water generated as the reaction progresses to outside the reaction system.
    Type: Application
    Filed: May 20, 2013
    Publication date: May 28, 2015
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kenji Yagi, Kenya Ishida
  • Patent number: 9029593
    Abstract: Provided is an amide ester that is useful as an intermediate manufacturing product for an aroma compound such as spilanthol or the like. Also provided is a spilanthol manufacturing method using said amide ester. High-purity spilanthol can be manufactured by reacting an amide ester represented by general formula (1) with a basic compound. (In the formula, R1 represents a C1-6 alkyl group or a phenyl group that may be substituted with a C1-4 alkyl group, a C1-4 alkoxy group, or a halogen atom; R2 represents a C1-8 hydrocarbon group; and the wavy lines represent cis configurations, trans configurations, or a mixture of the two configurations.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: May 12, 2015
    Assignee: Takasago International Corporation
    Inventors: Shigeru Tanaka, Kenya Ishida, Kenji Yagi, Hideo Ujihara
  • Patent number: 8986660
    Abstract: Disclosed is a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling, a sensate composition which comprises the same, and various products that comprise said sensate composition.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: March 24, 2015
    Assignee: Takasago International Corporation
    Inventors: Kazuma Hojo, Takashi Aida, Kenya Ishida
  • Publication number: 20150011799
    Abstract: An object of the present invention is to provide a method for producing an ether compound easily in a small number of steps at lower costs in high yields. The present invention relates to a method in which the ether compound represented by the general formula (1) is produced by reacting the specific carbonyl compound specified in the general formula (2) and the specific dialkoxy compound specified in the general formula (3) with hydrogen in the presence of a hydrogenation catalyst and an acidic substance to perform hydrogenation.
    Type: Application
    Filed: February 5, 2013
    Publication date: January 8, 2015
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Yasuhiro Komatsuki, Kenya Ishida, Kenji Yagi
  • Publication number: 20140364649
    Abstract: Provided is a method for producing an optically active ceramide by an N-acylation (amidation) reaction of an optically active aminodiol, wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely, provided is a method for producing a high-purity ceramide that has high diastereo purity with high yield. A high-purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1-5 carbon atoms of an aliphatic carboxylic acid having 12-24 carbon atoms, said aliphatic carboxylic acid optionally having a hydroxyl group, in a hydrocarbon solvent having 5-10 carbon atoms; and a step wherein an alcohol having 1-3 carbon atoms is added into the reaction mixture obtained in the preceding step, thereby causing crystals to precipitate.
    Type: Application
    Filed: November 7, 2012
    Publication date: December 11, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kenya Ishida, Kenji Yagi
  • Publication number: 20140328771
    Abstract: [Problem] The present invention provides: a composition for imparting a cooling sensation, which contains 3-menthoxy propanol; and a method for producing 3-menthoxy propanol with high selectivity and high yield using 3-menthoxy-1,2-epoxypropane as a starting material. [Solution] The present invention relates to: a method for producing 3-menthoxy propanol with high selectivity and high yield by performing catalytic hydrogenation of 3-menthoxy-1,2-epoxypropane in the presence of a heterogeneous metal catalyst such as a cobalt, a ruthenium catalyst or a nickel catalyst; and an excellent composition for imparting a cooling sensation, which contains a mixture of 3-menthoxy-1-propanol and 1-menthoxy-2-propanol.
    Type: Application
    Filed: October 1, 2012
    Publication date: November 6, 2014
    Applicant: Takasago International Corporation
    Inventors: Shigeru Tanaka, Kenya Ishida
  • Patent number: 8865191
    Abstract: Bioavailability of a ceramide, which is a minimally soluble material of a skin care composition exhibiting an excellent effect is enhanced by combining at least one component selected from ceramides represented by Formula (1): and at least one component selected from aliphatic alcohol having 12 to 30 carbon atoms.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: October 21, 2014
    Assignee: Takasago International Corporation
    Inventors: Kenya Ishida, Kenichiro Shiroyama
  • Publication number: 20140296562
    Abstract: The present invention relates to a novel method for producing an optically active ?-hydroxy-?-aminocarboxylic acid ester, the method comprising performing an asymmetric reduction reaction of a ?-keto-?-aminocarboxylic acid ester by use of a ruthenium complex as a catalyst.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 2, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Shigeru Tanaka, Taichiro Touge, Hideki Nara, Kenya Ishida
  • Patent number: 8846651
    Abstract: It is to provide a technique for preventing aggregation or caking of menthol at the time of its keeping. In addition, it is to provide a lipid composition, which can show excellent thermal stability even in the case of high temperature at the time of keeping menthol and at the time of blending in a product, does not cause mutual aggregation of powders, particles, flakes, pellets, sticks and the like of menthol, and can maintain its shape retention property. From 10 to 50% by mass of sterols are added to and mixed with from 50 to 90% by mass of menthol, and the resultant is melted with heating. Paraffins may be further added and mixed in an amount of 20% by mass or less, based on the lipid composition.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: September 30, 2014
    Assignee: Takasago International Corporation
    Inventors: Kenya Ishida, Chiyomi Birou, Tetsuya Yamamoto