Patents by Inventor Kenzi Miyai
Kenzi Miyai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5663163Abstract: The present invention relates to new cephem compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same and anti-bacterial methods of using the same. The subject cephem compounds comprise a thiadiazine ring bonded to the cephem through an iminoacetamido chain and a pyarzolium ring bonded to the cephem through a methylene chain.Type: GrantFiled: January 22, 1996Date of Patent: September 2, 1997Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
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Patent number: 5210080Abstract: The invention relates to compounds of antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl or lower alkenyl,R.sup.3 is lower alkyl, hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.4 is amino, protected amino, lower alkylamino, protected lower alkylamino, carboxy(lower)alkylamino, N-[protected carboxy(lower)alkyl]amino andR.sup.7 is hydrogen or lower alkyl, ora pharmaceutically acceptable salt thereof.Type: GrantFiled: April 9, 1991Date of Patent: May 11, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
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Patent number: 5194432Abstract: The invention relates to cephem compounds characterized by a substituted 2-pyrazolimethyl group and a 7-(aminothiazolyl) (hydroxyimino)-acetamido group and certain derivatives thereof, to pharmaceutical compositions comprising the same and to use for treatment of infectious diseases.Type: GrantFiled: July 17, 1990Date of Patent: March 16, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
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Patent number: 5187160Abstract: The invention relates to antimicrobial compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino, R.sup.2 is ethyl, propyl or lower alkenyl,R.sup.3 is COO .theta., carboxy or a protected carboxy,R.sup.4 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.5 is amino or a protected amino,X.sup..theta. is an anion, andn is 0 or 1,or,R.sup.1, R.sup.3, R.sup.5, X.sup..theta. and n are each as defined above,R.sup.2 is lower alkyl, andR.sup.4 is 3-hydroxypropyl, with proviso that(i) when R.sup.3 is COO.sup..theta., then n is 0, and(ii) when R.sup.3 is carboxy or a protected carboxy, then n is 1,or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 23, 1990Date of Patent: February 16, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kazuo Sakane, Kohji Kawabata, Kenzi Miyai, Yoshiko Inamoto
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Patent number: 5162520Abstract: The invention relates to intermediate compounds of the formula: ##STR1## wherein R.sup.3 is a lower alkyl, hydroxy(lower)alkyl or a protected hydroxy(lower)alkyl,R.sup.4 is amino or a protected amino group, andR.sup.5 is hydrogen or lower alkyl, or a salt thereof,useful in the preparation of compounds of antimicrobial activity.Type: GrantFiled: January 27, 1992Date of Patent: November 10, 1992Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
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Patent number: 5108997Abstract: The invention relates to a compound, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 and R.sup.4 are each amino or a protected amino group,R.sup.2 is carboxy(lower) alkyl or a protected carboxy(lower) alkyl,R.sup.3 is lower alkyl, andR.sup.5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 6, 1989Date of Patent: April 28, 1992Assignee: Fujisawa Pharmaceuticals Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
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Patent number: 4960766Abstract: The invention relates to cephem compounds characterized by a substituted 2-pyrazoliomethyl group and a 7-(aminothiazolyl)(alkoxyimino)-acetamido group and certain derivatives thereof, to pharmaceutical compositions comprising the same and to use for treatment of infections diseases.Type: GrantFiled: November 14, 1986Date of Patent: October 2, 1990Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
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Patent number: 4952578Abstract: The object of the invention is a new cephem compound with antimicrobial activity used for the treatment of infectious diseases of the general formula: ##STR1## wherein R1 is amino or a protected aminoR2 is lower alkyl which may have 1 to 3 halogensR3 is COO.sup..crclbar., carboxy or a protected carboxyR4 is hydroxy(lower)alkyl or protected hydroxy(lower)alkylR5 is amino or a protected aminoR6 is hydrogen or lower alkylX.sup..crclbar. is an anion, andn is 0 or 1with proviso that(i) when R3 is COO.sup..crclbar., then n is 0, and(ii) when R3 is carboxy or a protected carboxy, then n is 1,and pharmaceutically acceptable salt thereof.Type: GrantFiled: September 7, 1988Date of Patent: August 28, 1990Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kazuo Sakane, Kohji Kawabata, Kenzi Miyai, Yoshiko Inamoto
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Patent number: 4927818Abstract: 7 .beta.-[2-5 amino-1, 2, 4 thiadiazol-3yl) 2(carboxy lower alkyleneoxyimino) acetamido]-3-(3-amino-2-alkyl-1-pyrazolio) methyl 3 cephem 4 carboxylates are prepared. They are antibiotics.Type: GrantFiled: August 28, 1987Date of Patent: May 22, 1990Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
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Patent number: 4761410Abstract: The invention relates to antimicrobial compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is carboxy or a protected carboxy group andR.sup.3 is thiadiazolylthiomethyl or thiadiazolylthiomethyl substituted with lower alkyl, and pharmaceutically acceptable salts thereof.Type: GrantFiled: December 31, 1985Date of Patent: August 2, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Teruaki Matuo
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Patent number: 4631274Abstract: The invention relates to novel halovinyl cephem derivatives of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is a group of the formula:R.sup.4 --A--CONH--in which R.sup.4 is cyano(lower)alkenylthio or a group of the formula: ##STR2## in which R.sup.6 is hydrogen, amino or a protected amino group, andA is carbonyl, lower alkylene, hydroxy(lower)alkylene or a group of the formula: ##STR3## in which R.sup.5 is hydrogen, carboxy(lower)alkyl or protected carboxy(lower)alkyl;R.sup.2 is carboxy or a protected carboxy group; andX is halogen, and pharmaceutically acceptable salts thereof.Type: GrantFiled: February 25, 1985Date of Patent: December 23, 1986Assignee: Fujisawa Pharmceutical Co., Ltd.Inventors: Takao Takaya, Kazuo Sakane, Hideaki Yamanaka, Kenzi Miyai
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Patent number: 4487768Abstract: The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, andR.sup.3 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 22, 1982Date of Patent: December 11, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Takaya, Takashi Masugi, Hisashi Takasugi, Kenzi Miyai