Patents by Inventor Kenzo Morinaga

Kenzo Morinaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration
    Patent number: 11219697
    Abstract: In certain embodiments osteoadsorptive fluorogenic substrates of cathepsin K (or other proteases) are provided. Utilizing a bisphosphonate targeting moiety, the fluorogenic substrates provide effective bone-targeted protease sensor(s). In certain embodiments the “probes” comprise cleavable fluorophore-quencher pair linked by a cathepsin K (or other protease) peptide substrate and tethered to a bisphosphonate. Unlike existing probes that are cleared within a few days in vivo, the probes described herein (e.g., OFS-1) allow for monitoring resorption over the course of longer time periods with a single dose.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: January 11, 2022
    Assignees: The Regents of the University of California, University of Southern California
    Inventors: Ichiro Nishimura, Akishige Hokugo, Kenzo Morinaga, Charles E. McKenna, Boris A Kashemirov, Eric T. Richard
  • SMALL MOLECULE DRUGS AND METHODS TO ACCELERATE OSSEOINTEGRATION
    Publication number: 20210393857
    Abstract: Methods for enhancing or accelerating osseointegration of an implant into bone marrow of a subject, the methods comprising increasing expression of peripheral clock neuronal PAS domain protein 2 (NPAS2) in the bone marrow, are provided. Expression of NPAS2 is increased by administration of a Npas2 modulating compound to the subject.
    Type: Application
    Filed: November 4, 2019
    Publication date: December 23, 2021
    Applicant: The Regents of the University of California
    Inventors: Ichiro NISHIMURA, Akishige HOKUGO, Kenzo MORINAGA, Hodaka SASAKI
  • AN OSTEOADSORPTIVE FLUOROGENIC SUBSTRATE OF CATHEPSIN K FOR IMAGING OSTEOCLAST ACTIVITY AND MIGRATION
    Publication number: 20200215205
    Abstract: In certain embodiments osteoadsorptive fluorogenic substrates of cathepsin K (or other proteases) are provided. Utilizing a bisphosphonate targeting moiety, the fluorogenic substrates provide effective bone-targeted protease sensor(s). In certain embodiments the “probes” comprise cleavable fluorophore-quencher pair linked by a cathepsin K (or other protease) peptide substrate and tethered to a bisphosphonate. Unlike existing probes that are cleared within a few days in vivo, the probes described herein (e.g., OFS-1) allow for monitoring resorption over the course of longer time periods with a single dose.
    Type: Application
    Filed: July 13, 2018
    Publication date: July 9, 2020
    Applicants: The Regents of the University of California, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Ichiro Nishimura, Akishige Hokugo, Kenzo Morinaga, Charles E. McKenna, Boris A Kashemirov, Eric T. Richard