Abstract: The present invention relates to a stem cell having an immunosuppressive ability in which the expression or activity of a suppressor of cytokine signaling (SOCS) is inhibited, and a pharmaceutical composition for inhibiting immunity, which includes the stem cell. In addition, the present invention relates to a composition for inducing the immunosuppressive activity of a stem cell, including a suppressor of cytokine signaling (SOCS) expression or activity inhibitor. The inhibition of suppressor of cytokine signaling (SOCS) expression or activity, according to the present invention, may enhance the immunosuppressive ability of a stem cell, and the stem cell with enhanced immunosuppressive ability may be used as an effective cell therapeutic agent in an autoimmune disease, rejection upon organ transplantation, or an allergic disease.

Abstract: The present invention relates to a method for selecting high-efficacy mesenchymal stem cells for use in treating an immune disease, the method comprising a step of measuring a level of a particular immunosuppressive biomarker in mesenchymal stem cells in which the expression or activity of suppressor of cytokine signaling (SOCS) is downregulated, high-efficacy mesenchymal stem cells selected by the method, and a method for treating ii an immune disease by using the high-efficacy mesenchymal stem cells. Providing a method useful for acquiring functionally excellent mesenchymal stem cells having an ability to control immune reactions for clinical treatment of various immune diseases including graft-versus-host diseases and autoimmune diseases, the present invention can find useful applications in the therapy of immune diseases.

Abstract: The present invention relates to a method for sorting highly effective mesenchymal stem cells for treating an immune disorder, the method comprising a step of measuring the level of an immunosuppressive biomarker following IFN-? pretreatment simulation in mesenchymal stem cells; highly effective mesenchymal stem cells sorted by the method; and a method for treating an immune disorder by using the highly effective mesenchymal stem cells. The present invention can provide a useful method capable of obtaining functionally excellent mesenchymal stem cells having an immune reaction regulation capability and used for clinically treating various immune disorders including graft-versus-host disease and autoimmune disorders, and thus can be usefully used as a therapy for immune disorders.

Abstract: The present invention relates to a stem cell having an immunosuppressive ability in which the expression or activity of a suppressor of cytokine signaling (SOCS) is inhibited, and a pharmaceutical composition for inhibiting immunity, which includes the stem cell. In addition, the present invention relates to a composition for inducing the immunosuppressive activity of a stem cell, including a suppressor of cytokine signaling (SOCS) expression or activity inhibitor. The inhibition of suppressor of cytokine signaling (SOCS) expression or activity, according to the present invention, may enhance the immunosuppressive ability of a stem cell, and the stem cell with enhanced immunosuppressive ability may be used as an effective cell therapeutic agent in an autoimmune disease, rejection upon organ transplantation, or an allergic disease.