Patents by Inventor Ker Yu

Ker Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo[4,3,2-de]quinolin-8-amine compounds and methods of their preparation and use
    Patent number: 8486961
    Abstract: The present invention relates to compounds of formula I: methods of their use, processes for their preparation and isolated actinomycetes strains capable of preparing pyrrolo[4,3,2-de]quinolin-8-amine compounds.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: July 16, 2013
    Assignee: Wyeth LLC
    Inventors: Min He, Jeffrey Edwin Janso, Ker Yu, Leonard Alexander McDonald, Laurel Rita Barbieri, Ariamala Gopalsamy
  • 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS
    Publication number: 20100068204
    Abstract: Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.
    Type: Application
    Filed: September 14, 2009
    Publication date: March 18, 2010
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Gary Harold Birnberg, Gloria Jean MacEwan, Mercy Adufa Otteng, Pawel Wojciech Nowak, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Arie Zask, Ker Yu
  • Analogs of 17-hydroxywortmannin as PI3K inhibitors
    Patent number: 7666901
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, and R8 are defined herein.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: February 23, 2010
    Assignee: Wyeth
    Inventors: Arie Zask, Ping Cai, Jianxin Gu, Joshua Kaplan, Ker Yu, Tianmin Zhu
  • PYRROLO[4,3,2-DE]QUINOLIN-8-AMINE COMPOUNDS AND METHODS OF THEIR PREPARATION AND USE
    Publication number: 20100041692
    Abstract: The present invention relates to compounds of formula I: methods of their use, processes for their preparation and isolated actinomycetes strains capable of preparing pyrrolo[4,3,2-de]quinolin-8-amine compounds.
    Type: Application
    Filed: August 12, 2009
    Publication date: February 18, 2010
    Applicant: Wyeth
    Inventors: Min He, Jeffrey Edwin Janso, Ker Yu, Leonard Alexander McDonald, Laurel Rita Barbieri, Ariamala Gopalsamy
  • WORTMANNIN-RAPALOG CONJUGATE AND USES THEREOF
    Publication number: 20080249124
    Abstract: An anti-neoplastic wortmannin conjugate is described formed by a linking a rapalog and wortmannin. Such a linkage is removable following administration to a subject. Use of such a conjugate in an antineoplastic regimen is described.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 9, 2008
    Applicant: Wyeth
    Inventors: Jianxin GU, Ker Yu, Judy Lucas, Mark Ruppen, Arie Zask, Semiramis Ayral-Kaloustian
  • WORTMANNIN-RAPAMYCIN CONJUGATE AND USES THEREOF
    Publication number: 20080249123
    Abstract: A rapamycin—wortmannin conjugate is described, in which the conjugate is formed by linking the rapamycin and wortmannin together in such a manner that the rapamycin and the wortmannin are separated following administration to a subject. Use of such a conjugate in an antineoplastic regimen is described.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 9, 2008
    Applicant: Wyeth
    Inventors: JIANXIN GU, Ker Yu, Judy Lucas, Mark Ruppen, Arie Zask, Semiramis Ayral-Kaloustian
  • PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS
    Publication number: 20080234262
    Abstract: The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
    Type: Application
    Filed: March 18, 2008
    Publication date: September 25, 2008
    Applicant: Wyeth
    Inventors: Arie Zask, Pawel Wojciech Nowak, Jeroen Cunera Verheijen, Kevin J. Curran, Joshua Kaplan, David Malwitz, Matthew Gregory Bursavich, Derek Cecil Cole, Semiramis Ayral-Kaloustian, Ker Yu, David James Richard, Mark Lefever
  • Analogs of 17-hydroxywortmannin as P13K inhibitors
    Publication number: 20060128793
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, and R8 are defined herein.
    Type: Application
    Filed: October 13, 2005
    Publication date: June 15, 2006
    Applicant: Wyeth
    Inventors: Arie Zask, Ping Cai, Jianxin Gu, Joshua Kaplan, Ker Yu, Tianmin Zhu
  • Water soluble wortmannin derivatives
    Publication number: 20040213757
    Abstract: This invention relates to soluble derivatives of wortmannin that utilizes water-soluble polymers as carriers for a drug and includes compounds having the structures as described within the specification.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 28, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Tianmin Zhu, Ker Yu, Judy Lucas, Jianxin Gu, Arie Zask