Patents by Inventor Keren TURJEMAN

Keren TURJEMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250114304
    Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, with the pharmaceutical composition including a non-ionic tonicity agent of a polyol such as mannitol, and liposomes having a membrane that includes at least a phospholipid selected from the group consisting of dimyristoylphosphatidylcholine (DMPC); a mixture of DMPC and dipalmitoyl-phosphatidylcholine (DPPC); a mixture of DMPC and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC); a mixture of DMPC and N-palmitoyl-D-erythro-sphingosy lphosphorylcholine (D-erythro C16); and a mixture of DMPC and 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine (C-15); wherein the pharmaceutical composition is essentially free of hyaluronic acid and any additional pharmaceutically active agents, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C., and the joint has a joint temperature which is above the phase transition temperature.
    Type: Application
    Filed: December 17, 2024
    Publication date: April 10, 2025
    Applicant: MOEBIUS MEDICAL LTD.
    Inventors: Yechezkel BARENHOLZ, Yaniv DOLEV, Keren TURJEMAN, Gadi SARFATI, Maty AYAL-HERSHKOVITZ
  • Publication number: 20250114303
    Abstract: The present invention relates to a method of determining the trapped volume and the trapped aqueous volume of a plurality of liposomes in a liposomal composition. The method can be used for calculating the concentration of an active pharmaceutical ingredient entrapped within the liposomes and for quality assurance of a pre-formed liposomal composition.
    Type: Application
    Filed: January 1, 2023
    Publication date: April 10, 2025
    Applicants: Moebius Medical Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yechezkel BARENHOLZ, Keren TURJEMAN, Ron PINKUS
  • Patent number: 12214077
    Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.
    Type: Grant
    Filed: August 15, 2021
    Date of Patent: February 4, 2025
    Assignee: MOEBIUS MEDICAL LTD.
    Inventors: Yechezkel Barenholz, Yaniv Dolev, Keren Turjeman, Gadi Sarfati, Maty Ayal-Hershkovitz
  • Publication number: 20210369613
    Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.
    Type: Application
    Filed: August 15, 2021
    Publication date: December 2, 2021
    Inventors: Yechezkel BARENHOLZ, Yaniv DOLEV, Keren TURJEMAN, Gadi SARFATI, Maty AYAL-HERSHKOVITZ
  • Patent number: 11123293
    Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 21, 2021
    Assignee: Moebius Medical Ltd.
    Inventors: Yechezkel Barenholz, Yaniv Dolev, Keren Turjeman, Gadi Sarfati, Maty Ayal-Hershkovitz
  • Patent number: 10722599
    Abstract: Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: July 28, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yechezkel Barenholz, Rivka Cohen, Kirill Makedonski, Eylon Yavin, Andreas Ingemann Jensen, Keren Turjeman
  • Publication number: 20200170948
    Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.
    Type: Application
    Filed: August 21, 2018
    Publication date: June 4, 2020
    Inventors: Yechezkel BARENHOLZ, Yaniv DOLEV, Keren TURJEMAN, Gadi SARFATI, Maty Ayal HERSHKOVITZ
  • Publication number: 20180043036
    Abstract: Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.
    Type: Application
    Filed: February 4, 2016
    Publication date: February 15, 2018
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., QBI Enterprises Ltd., Rosetta Genomics, Biolab Ltd.
    Inventors: Sharon AVKIN-NACHUM, Tirtsa KLEINMAN, Noga YERUSHALMI, Yechezkel BARENHOLZ, Rivka COHEN, Kirill MAKEDONSKI, Eylon YAVIN, Andreas Ingemann JENSEN, Keren TURJEMAN