Patents by Inventor Kerou ZHANG

Kerou ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CHIMERIC AMPLICON FORMATION
    Publication number: 20240218435
    Abstract: Provided herein are compositions and methods for formation of amplicons having a chimeric sequence, partially derived from a target nucleic acid and partially derived from a rationally designed oligonucleotide. The provided compositions provide for high-yield, induced template switching between the target nucleic acid and the rationally designed oligonucleotide as the template during polymerase extension, achieving inheritance of information from both within only one cycle.
    Type: Application
    Filed: April 29, 2022
    Publication date: July 4, 2024
    Applicant: William Marsh Rice University
    Inventors: David ZHANG, Kerou ZHANG, Ping SONG
  • NON-EXTENSIBLE OLIGONUCLEOTIDES IN DNA AMPLIFICATION REACTIONS
    Publication number: 20230340581
    Abstract: Provided herein are non-extensible oligonucleotides for suppressing enzymatic extension through rationally designed secondary structures at the 3? end. Embodiments of the invention include procedures for integration with real-time polymerase chain reaction, blocker displacement amplification in quantitative PCR, next generation sequencing (NGS), and long-read sequencing.
    Type: Application
    Filed: May 27, 2021
    Publication date: October 26, 2023
    Applicant: William Marsh Rice University
    Inventors: David ZHANG, Kerou ZHANG
  • AMPLICON COMPREHENSIVE ENRICHMENT
    Publication number: 20230250470
    Abstract: Provided herein are reagents and methods for comprehensively enriching potential variants within targeted regions, named Amplicon Comprehensive Enrichment (ACE). The sequence variants enriched can include single nucleotide polymorphisms (SNPs), single nucleotide variants, or small insertions and deletions. Embodiments include procedures for integration with real-time polymerase chain reaction, next generation sequencing (NGS), and long-read sequencing.
    Type: Application
    Filed: June 25, 2021
    Publication date: August 10, 2023
    Applicant: William Marsh Rice University
    Inventors: David ZHANG, Kerou ZHANG, Ping SONG
  • QUANTIFYING FOREIGN DNA IN LOW-VOLUME BLOOD SAMPLES USING SNP PROFILING
    Publication number: 20220042100
    Abstract: Provided herein are methods for quantifying foreign cell-free DNA (cfDNA) via SNP profiling of low-volume blood sample. The methods allow for monitoring the status of organ transplant rejection through analysis of small volumes of patient capillary blood samples collected non-invasively with fingersticks or other devices. The methods also allow for guiding the dosage of immunosuppressant and for preparing for a new organ transplant in case of imminent organ failure.
    Type: Application
    Filed: December 5, 2019
    Publication date: February 10, 2022
    Inventors: David Yu ZHANG, Xi CHEN, Omid VEISEH, Peng DAI, Kerou ZHANG