Patents by Inventor Kerry Combs

Kerry Combs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Carboxylic Acids
    Publication number: 20090082392
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
    Type: Application
    Filed: April 15, 2008
    Publication date: March 26, 2009
    Inventors: Michael C. Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu
  • Heterocycle Substituted Carboxylic Acids
    Publication number: 20080146574
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Application
    Filed: February 12, 2008
    Publication date: June 19, 2008
    Inventors: Darren Whitehouse, Shaojing Hu, Haiquan Fang, Kerry Combs, Michael C. Van Zandt
  • Substituted carboxylic acids
    Patent number: 7358364
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: April 15, 2008
    Assignee: The Institute for Pharmaceutical Discovery LLC
    Inventors: Michael C. Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu
  • Heterocycle substituted carboxylic acids
    Patent number: 7329680
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: February 12, 2008
    Assignee: The Institute for Pharmaceutical Discovery, LLC
    Inventors: Darren Whitehouse, Shaojing Hu, Haiquan Fang, Kerry Combs, Michael C. Van Zandt
  • Heterocycle substituted carboxylic acids
    Publication number: 20060122222
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Application
    Filed: November 18, 2005
    Publication date: June 8, 2006
    Inventors: Darren Whitehouse, Shaojing Hu, Kerry Combs, Michael Van Zandt
  • Substituted carboxylic acids
    Publication number: 20060094747
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula I: which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
    Type: Application
    Filed: October 28, 2005
    Publication date: May 4, 2006
    Inventors: Michael Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu
  • Heterocycle substituted carboxylic acids
    Publication number: 20050004114
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Application
    Filed: April 30, 2004
    Publication date: January 6, 2005
    Inventors: Darren Whitehouse, Shaojing Hu, Haiquan Fang, Kerry Combs, Michael Van Zandt
  • Substituted carboxylic acids
    Publication number: 20040266788
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): 1
    Type: Application
    Filed: April 14, 2004
    Publication date: December 30, 2004
    Applicant: The Institute for Pharmaceutical Discovery LLC
    Inventors: Michael C. Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu