Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.

Abstract: The present invention provides the use of a protein found in breast, prostate, pancreatic and colon cancer cell membranes, known as BCMP 7, in the diagnosis, screening, treatment and prophylaxis of breast, prostate, pancreatic and/or colon cancer, as well as compositions comprising BCMP 7, including vaccines and antibodies that are immunospecific for BCMP 7.

Abstract: The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.

Abstract: The present invention provides a homologue to heparanase which is present in three splice variants.

Abstract: The present invention provides a homologue to heparanase which is present in three splice variants.

Abstract: The present invention provides the use of a protein found in breast, prostate, pancreatic and colon cancer cell membranes, known as BCMP 7, in the diagnosis, screening, treatment and prophylaxis of breast, prostate, pancreatic and/or colon cancer, as well as compositions comprising BCMP 7, including vaccines and antibodies that are immunospecific for BCMP 7.

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Schizophrenia, for monitoring the effectiveness of Schizophrenia treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Schizophrenia-Associated Features (SFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Schizophrenia-Associated Protein Isoforms (SPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated SPIs, antibodies immunospecific for SPIs, and kits comprising the aforesaid.

Abstract: The present invention relates to the use of a protein (BCMP84) isolated from breast cancer cell line membrane preparations, compositions comprising the protein, including vaccines, and antibodies which are immunospecific for the protein in the diagnosis, treatment and/or prophylaxis of breast, bladder and/or tonsil cancer.

Abstract: The present invention provides a protein (BCMP 84) isolated from breast cancer cell line membrane preparations, compositions comprising the protein, including vaccines and antibodies which are immunospecific for the protein. The use of an active agent selected from the protein, corresponding nucleic acids, antibodies and the like, including pharmaceutical compositions, in the diagnosis, screening, treatment and prophylaxis of cancers including breast cancer is also provided.

Abstract: The present invention provides a protein (ADPI-41) identified in brain tissue, compositions comprising the protein, including vaccines and antibodies, which are immunospecific for the protein. The use of the protein in the diagnosis, screening, treatment and prophylaxis of Alzheimer's disease is also provided.

Abstract: The present invention provides a homologue to heparanase which is present in three splice variants.

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of BAD, for monitoring the effectiveness of BAD treatment, and for drug development. BAD-Associated Features (DFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides BAD-Associated Protein Isoforms (DPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated DPIs, antibodies immunospecific for DPIs, and kits comprising the aforesaid.

Abstract: The present invention provides the use of a protein found in breast cancer cell membranes, known as BCMP 11, in the diagnosis, screening, treatment and prophylaxis of breast cancer or prostate cancer, as well as compositions comprising BCMP 11, including vaccines and antibodies that are immunospecific for BCMP 11.

Abstract: The present invention provides the use of a protein found in breast cancer cell membranes, known as BCMP 7, in the diagnosis, screening, treatment and prophylaxis of breast cancer or prostate cancer, as well as compositions comprising BCMP 7, including vaccines and antibodies that are immunospecific for BCMP 7.