Abstract: Provided herein are engineered, regulatable polypeptides comprising a payload and a drug responsive domains (DRD), wherein the DRD is operably linked to the payload and wherein the DRD is responsive to a ligand. The DRD is optionally FKBP13, either wildtype or a variant thereof.

Abstract: An absorbent article includes a bodyside liner, an absorbent core, and an acquisition layer positioned between the bodyside liner and the absorbent core. Properties of the bodyside liner, absorbent core, and acquisition layer may facilitate fluid flow within a target zone and provide the absorbent article with desired dryness.

Abstract: A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD). The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample.

Abstract: Methods and systems for analyzing vehicle operation data associated with a temporary or periodic usage of a vehicle by a driver. In aspects, the vehicle operation data may be analyzed to assess a performance of the driver during operation of the vehicle. Based on the performance of the driver, the driver may qualify for a reward.

Abstract: A hollow fan blade comprises a sheath, an airfoil and a cover. The sheath forms a pressure side wall and has an exterior surface. The airfoil forms a suction side wall and has an exterior surface. There are a plurality of ribs extending between the pressure side wall and the suction side wall, where the plurality of ribs partition the hollow airfoil into one or more cavities. The cover is disposed in the one or more cavities to protect the plurality of ribs. The cavities are filled with a polymeric foam.

Abstract: Systems and methods are disclosed for generating one or more smart contracts for deployment onto a blockchain. The systems and methods may include (1) receiving vehicle sensor data generated from sensors mounted on or within (a) one or more vehicles, or (b) electronic devices; (2) analyzing the vehicle sensor data to determine one or more parametric events, wherein each of the parametric events is associated with a corresponding severity of loss; (3) generating, for each of the one or more parametric events, a corresponding smart contract that is configured to (i) receive a transaction from a computing device, and (ii) automatically execute on the blockchain when the transaction indicates that a parametric event corresponding to the smart contract has occurred; and (4) deploying the smart contract at a particular address on the blockchain.

Abstract: Systems and methods are disclosed for generating one or more smart contracts for deployment onto a blockchain. The systems and methods may include (1) receiving vehicle sensor data generated from sensors mounted on or within (a) one or more vehicles, or (b) electronic devices; (2) analyzing the vehicle sensor data to determine one or more parametric events, wherein each of the parametric events is associated with a corresponding severity of loss; (3) generating, for each of the one or more parametric events, a corresponding smart contract that is configured to (i) receive a transaction from a computing device, and (ii) automatically execute on the blockchain when the transaction indicates that a parametric event corresponding to the smart contract has occurred; and (4) deploying the smart contract at a particular address on the blockchain.

Abstract: Systems and methods are disclosed for generating one or more smart contracts for deployment onto a blockchain. The systems and methods may include (1) receiving vehicle sensor data generated from sensors mounted on or within (a) one or more vehicles, or (b) electronic devices; (2) analyzing the vehicle sensor data to determine one or more parametric events, wherein each of the parametric events is associated with a corresponding severity of loss; (3) generating, for each of the one or more parametric events, a corresponding smart contract that is configured to (i) receive a transaction from a computing device, and (ii) automatically execute on the blockchain when the transaction indicates that a parametric event corresponding to the smart contract has occurred; and (4) deploying the smart contract at a particular address on the blockchain.

Abstract: Systems and methods are disclosed for generating one or more smart contracts for deployment onto a blockchain. The systems and methods may include (1) receiving vehicle sensor data generated from sensors mounted on or within (a) one or more vehicles, or (b) electronic devices; (2) analyzing the vehicle sensor data to determine one or more parametric events, wherein each of the parametric events is associated with a corresponding severity of loss; (3) generating, for each of the one or more parametric events, a corresponding smart contract that is configured to (i) receive a transaction from a computing device, and (ii) automatically execute on the blockchain when the transaction indicates that a parametric event corresponding to the smart contract has occurred; and (4) deploying the smart contract at a particular address on the blockchain.

Abstract: Disclosed is a method of repairing a rear cone segment erosion coating including removing a portion of an existing fluoroelastomer coating from a rear cone segment to form a repair area; forming a cured replacement erosion coating corresponding to the repair area, wherein the cured replacement erosion coating has a layer of fluoroelastomer and a layer of fibrous reinforcement; preparing the repair area and the cured replacement erosion coating for adhesion; locating the prepared cured replacement erosion coating on the prepared repair area; and adhering the prepared cured replacement erosion coating to the prepared repair area. Also disclosed is a cured replacement erosion coating and a repaired inlet nose cone.

Abstract: The present invention relates to compositions comprising a Cas12i2 polypeptide and an RNA guide, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions.

Abstract: A hybrid abradable seal including a stator substrate having an external surface; a casing coupled to the external surface, the casing including radial walls extending radially from the external surface; an abradable material disposed within the casing; the abradable material and the casing being coupled together and configured to resist a deflection responsive to engine gas loads.

Abstract: A hybrid abradable seal including a stator substrate having an external surface; a casing coupled to the external surface, the casing including radial walls extending radially from the external surface; an abradable material disposed within the casing; the abradable material and the casing being coupled together and configured to resist a deflection responsive to engine gas loads.

Abstract: Disclosed is a method of repairing a rear cone segment erosion coating including removing a portion of an existing fluoroelastomer coating from a rear cone segment to form a repair area; forming a cured replacement erosion coating corresponding to the repair area, wherein the cured replacement erosion coating has a layer of fluoroelastomer and a layer of fibrous reinforcement; preparing the repair area and the cured replacement erosion coating for adhesion; locating the prepared cured replacement erosion coating on the prepared repair area; and adhering the prepared cured replacement erosion coating to the prepared repair area. Also disclosed is a cured replacement erosion coating and a repaired inlet nose cone.

Abstract: Disclosed is a method of repairing a rear cone segment erosion coating including removing a portion of an existing fluoroelastomer coating from a rear cone segment to form a repair area; forming a cured replacement erosion coating corresponding to the repair area, wherein the cured replacement erosion coating has a layer of fluoroelastomer and a layer of fibrous reinforcement; preparing the repair area and the cured replacement erosion coating for adhesion; locating the prepared cured replacement erosion coating on the prepared repair area; and adhering the prepared cured replacement erosion coating to the prepared repair area. Also disclosed is a cured replacement erosion coating and a repaired inlet nose cone.

Abstract: A system, includes a computing system having an interface configured to receive a first signal indicative of operational data of a device engaged in hydrocarbon and/or emergency response operations. The computing system further includes a memory configured to store a value corresponding to non-operational data related to a crewmember interaction with the device and/or operational data from technical/plant barrier elements. The computing system additionally includes a processor configured to generate a graphical user interface, wherein the graphical user interface comprises a status identifier generated based upon the first signal and the value.

Abstract: A method of sealing a first component to a second component comprising the steps of locating at least one fiber reinforced polyimide resin layer against a first sealing surface on a first component and against a second sealing surface on a second component. At least one fiber reinforced polyimide resin layer is compressed against the first sealing surface and the second sealing surface prior to curing at least one fiber reinforced polyimide resin layer. At least one fiber reinforced polyimide resin layer is heated to promote flow and conformation to the first sealing surface and the second sealing surface. At least one fiber reinforced polyimide resin layer is cured to provide a fluid tight seal between the first component and the second component.

Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.

Abstract: A nephelometer that measures turbidity of low volume suspensions using measurements of light transmitted through and/or scattered by the sample. The sample suspension is placed in a tiered cuvette adapted to facilitate measuring the turbidity of low volume samples. The lower portion of the cuvette has smaller dimensions, in horizontal cross section, than the top portion. Both lower and upper portions have angled surfaces. The lower, smaller portion of the cuvette is interrogated by the nephelometer.