Abstract: The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5?ITR-B1-BA-B2-BX-BB-BY-B3-3?ITR wherein: B1 is bond or comprises: E1A, E1B or E1A-E1B; BA comprises-E2B-L1-L2-L3-E2A-L4; B2 is a bond or comprises: E3; BX is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; BB comprises L5; BY is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B3 is a bond or comprises: E4; wherein at least one of BX or BY is not a bond, pharmaceutical compositions comprising the same and use of the viruses and compositions in treatment, particularly in the treatment of cancer. The disclosure also extends to plasmids and processes employed to prepare the said viruses.

Abstract: A method is for manufacturing a plurality of silicon microneedles which have a bevelled tip. The method includes providing a silicon substrate having a front face and a rear face, forming a first mask arrangement on the front face of the substrate, the first mask arrangement defining one or more gaps, and performing a SF6 based plasma etch of the front face through the gaps in the first mask arrangement to provide one or more etch features having a sloping face. The SF6 based plasma etch undercuts the first mask arrangement with an undercut that is at least 10% of the depth of a corresponding etch feature.

Abstract: A method is for manufacturing a plurality of silicon microneedles which have a bevelled tip. The method includes providing a silicon substrate having a front face and a rear face, forming a first mask arrangement on the front face of the substrate, the first mask arrangement defining one or more gaps, and performing a SF6 based plasma etch of the front face through the gaps in the first mask arrangement to provide one or more etch features having a sloping face. The SF6 based plasma etch undercuts the first mask arrangement with an undercut that is at least 10% of the depth of a corresponding etch feature.

Abstract: The invention provides an isolated polynucleotide comprising the sequence of SEQ ID NO: 1 or a variant thereof, wherein the variant encodes a polypeptide capable of modulating in a plant tolerance to at least one environmental stress selected from drought, cold, freezing, heat and salinity. The invention also provides construct, vectors, host cells, plant cells and plants genetically modified to comprise the polynucleotide. The invention also provides methods for producing and selecting plants that are tolerant to at least one environmental stress selected from drought, cold, freezing, heat and salinity, making use of the polynucleotides of the invention.

Abstract: The invention provides the isolated promoter polynucleotide sequence of SEQ ID NO: 1 from perennial ryegrass (Lolium perenne L.), and fragments and variants thereof. The invention also provides constructs, plant cells and plant genetically modified to contain the promoter polynucleotide. The invention also provides methods for producing plants with altered gene expression and traits via genetic transformation of plants with the promoter polynucleotide.

Abstract: The invention provides the isolated promoter polynucleotide sequence of SEQ ID NO:1, and fragments and variants thereof. The invention also provides constructs, plant cells and plants genetically modified to contain the promoter polynucleotide. The invention also provides methods for producing plants with altered gene expression and traits via genetic transformation of plants with the promoter polynucleotides.

Abstract: Computer implemented method, system and computer usable program code for facilitating utilization of data. A computer implemented method for facilitating utilization of data includes receiving data, wherein the received data is in a first representation. The received data is converted from the first representation to a common representation that is mapped to the first representation using an external configuration file. The common representation of the data is output to facilitate utilization of the data.

Abstract: The invention provides the isolated promoter polynucleotide sequence of SEQ ID NO: 1 from perennial ryegrass (Lolium perenne L.), and fragments and variants thereof. The invention also provides constructs, plant cells and plant genetically modified to contain the promoter polynucleotide. The invention also provides methods for producing plants with altered gene expression and traits via genetic transformation of plants with the promoter polynucleotide.

Abstract: The invention provides an isolated polynucleotide comprising the sequence of SEQ ID NO: 1 or a variant thereof, wherein the variant encodes a polypeptide capable of modulating in a plant tolerance to at least one environmental stress selected from drought, cold, freezing, heat and salinity. The invention also provides construct, vectors, host cells, plant cells and plants genetically modified to comprise the polynucleotide. The invention also provides methods for producing and selecting plants that are tolerant to at least one environmental stress selected from drought, cold, freezing, heat and salinity, making use of the polynucleotides of the invention.

Abstract: The invention provides an isolated polynucleotide encoding a polypeptide with the sequence of SEQ ID NO: 1 or a variant thereof, wherein the variant is a polypeptide capable of modulating in a plant at least one of: i) biomass, ii) seed yield, and III) tolerance to at least one environmental stress selected from drought, cold, freezing, heat and salinity. The invention also provides, construct, vectors, host cells, plant cells and plants genetically modified to comprise the polynucleotide. The invention also provides methods for producing and selecting plants that are altered for at least one of: i) biomass, ii) seed yield, and iii) tolerance to at least one environmental stress selected from drought, cold, freezing, heat and salinity, making use of the polynucleotides of the invention.

Abstract: The invention provides the isolated promoter polynucleotide sequence of SEQ ID NO:1, and fragments and variants thereof. The invention also provides constructs, plant cells and plants genetically modified to contain the promoter polynucleotide. The invention also provides methods for producing plants with altered gene expression and traits via genetic transformation of plants with the promoter polynucleotides.

Abstract: This invention provides an isolated promoter polynucleotide comprising the sequence of SEQ ID NO:1, and variants and fragments thereof capable of controlling transcription of an operably linked polynucleotide in a plant. The invention also provides the constructs, vectors, host cells, plant cells and plants transformed with the isolated promoter polynucleotide. The invention also provides methods of use of the isolated promoter polynucleotide.

Abstract: A composite masonry building block (1) that has an inner core (20) of lighter density than an outer face and includes upper most protrusions (4, 73) and matching lowermost cavities (5, 76) to have an interlocking arrangement with other like blocks. Also disclosed is an inner lighter density material which includes an expanded plastic such as polystyrene with a cement binder. The upper (2) surface of the block (1) may include a plurality of protrusions and lower (3) may have a plurality of cavities (5). The arrangement of the protrusions (4) in relation to the upper surface (2) and the arrangement of cavities (5) in relation to lower surface (3) are such that the protrusions (4) will locate within and interlock with the consistently aligned and placed cavities of the adjacent block.

Abstract: Computer implemented method, system and computer usable program code for facilitating utilization of data. A computer implemented method for facilitating utilization of data includes receiving data, wherein the received data is in a first representation. The received data is converted from the first representation to a common representation that is mapped to the first representation using an external configuration file. The common representation of the data is output to facilitate utilization of the data.