Patents by Inventor Kerry W. Fowler

Kerry W. Fowler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6294561
    Abstract: Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: September 25, 2001
    Assignee: ICOS Corporation
    Inventors: Kerry W. Fowler, Joshua Odingo
  • Patent number: 6258833
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: July 10, 2001
    Assignee: ICOS Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward Kesicki, Amy Oliver, Laurence E. Burgess, John J. Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlacter
  • Patent number: 5401880
    Abstract: The present invention relate to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular with aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
    Type: Grant
    Filed: January 2, 1992
    Date of Patent: March 28, 1995
    Assignee: Oculon Corporation
    Inventors: John I. Clark, Kerry W. Fowler, Mark W. Orme, Louis J. Theodore
  • Patent number: 5247119
    Abstract: A class of substituted phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune or inflammatory diseases. Compounds of particular interest are of the formula ##STR1## wherein each of m and n is a number independently selected from one to five, inclusive; wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkenyl and alkynyl; wherein R.sup.6 is selected from loweralkyl; wherein each of R.sup.8, R.sup.9, R.sup.10 and R.sup.12 through R.sup.16 is independently selected from hydrido, hydroxy, alkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylalkenyl, alkylaminocarbonyl and alkoxyalkyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: September 21, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Kerry W. Fowler, John M. Farah, Jr., John P. McKearn, Richard A. Mueller, Susan A. Gregory
  • Patent number: 5098915
    Abstract: Substituted N-benzylpiperidine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compunds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: March 24, 1992
    Assignee: G. D. Searle & Co.
    Inventors: Bipinchandra N. Desai, Kerry W. Fowler, Alan E. Moormann
  • Patent number: 5070094
    Abstract: N-benzyl tropane amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: December 3, 1991
    Assignee: G. D. Searle & Co.
    Inventor: Kerry W. Fowler
  • Patent number: 5028616
    Abstract: N-benzylpiperidine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: July 2, 1991
    Assignee: G. D. Searle & Co.
    Inventors: Bipinchandra N. Desai, Kerry W. Fowler
  • Patent number: 4992446
    Abstract: Tricyclic quinolizine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: February 12, 1991
    Assignee: G. D. Searle & Co.
    Inventor: Kerry W. Fowler
  • Patent number: 4704382
    Abstract: The invention relates to compounds of the formula: ##STR1## which are useful cardiovascular agents.
    Type: Grant
    Filed: July 8, 1986
    Date of Patent: November 3, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Robert J. Chorvat, Kerry W. Fowler, James P. Snyder
  • Patent number: 4680295
    Abstract: This invention relates to octahydropyrido[1,2-c]pyrimidinones and hexahydropyrido[1,2-c]pyrimidinediones that are useful as inhibitors of cardiac arrhythmias and are therefore useful in the treatment of irregular heartbeat.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: July 14, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Kerry W. Fowler, Robert J. Chorvat
  • Patent number: 4628095
    Abstract: The invention relates to compounds of the formula: ##STR1## which are useful cardiovascular agents.
    Type: Grant
    Filed: June 5, 1985
    Date of Patent: December 9, 1986
    Assignee: G. D. Searle & Co.
    Inventors: Kurt J. Rorig, Stevan W. Djuric, Kerry W. Fowler, Chi-Dean Liang