Patents by Inventor Kersten M. Small

Kersten M. Small has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heart failure assessment based on alpha-2C adrenergic receptor polymorphisms
    Patent number: 7642052
    Abstract: Methods for cardiovascular disease assessment in an individual comprise detecting the presence or absence of a fragment encoding a polymorphic alpha-2C (?2C DEL322-325) adrenergic receptor in a sample from an individual; and detecting the presence or absence of a fragment encoding a polymorphic beta-1 adrenergic receptor (?1Arg389) in a sample from the individual. Methods for delaying development of cardiovascular disease in an individual, methods for delaying progression or early death associated with cardiovascular disease in an individual, methods of genetic counseling for cardiovascular disease in an individual are also provided.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: January 5, 2010
    Assignee: University of Cincinnati
    Inventors: Kersten M. Small, Stephen B. Liggett
  • Polymorphisms and Haplotypes of the Alpha 2C Adrenergic Receptor Gene
    Publication number: 20090228995
    Abstract: Methods and compositions for diagnosing and treating diseases are provided. The methods involve the discovery of a correlation between an ?2C-adrenergic receptor gene polymorphism, a combination of polymorphisms or a haplotype and the occurrence of diseases such as heart failure, cardiac arrhythmias, hypertension, behavioral and learning disorders, psychiatric diseases such as depression, obesity, and diabetes mellitus. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment selection for diseases such as heart failure, cardiac arrhythmias, hypertension, behavioral and learning disorders, psychiatric diseases such as depression, obesity, and diabetes mellitus. The invention also pertains to a composition of matter comprising polymorphisms and haplotypes of the ?2C-adrenergic receptor.
    Type: Application
    Filed: June 29, 2005
    Publication date: September 10, 2009
    Inventors: Stephen Bryant Liggett, Kersten M. Small
  • Alpha-2 adrenergic receptor polymorphisms
    Patent number: 7572603
    Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2B, alpha-2A, and alpha-2C adrenergic receptor and expressed alpha-2B, alpha-2A and alpha-2C adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system disease.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: August 11, 2009
    Assignee: University of Cincinnati
    Inventors: Kersten M. Small, Stephen B. Liggett
  • Alpha-2B-adrenergic receptor polymorphisms
    Patent number: 7229756
    Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2B adrenergic receptor and expressed alpha-2B adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system diseases.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: June 12, 2007
    Assignee: University of Cincinnati
    Inventors: Kersten M. Small, Stephen B. Liggett
  • Alpha-2A-adrenergic receptor polymorphisms
    Patent number: 7211386
    Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2A adrenergic receptor and expressed alpha-2A adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms and transgenic animals expressing alpha-2A adrenergic receptor molecules. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system diseases.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: May 1, 2007
    Assignee: University of Cincinnati
    Inventors: Kersten M. Small, Stephen B. Liggett
  • Alpha-2 adrenergic receptor polymorphisms
    Patent number: 7041810
    Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2B, alpha-2A, and alpha-2C adrenergic receptor and expressed alpha-2B, alpha-2A and alpha-2C adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system disease.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: May 9, 2006
    Assignee: University Of Cincinnati
    Inventors: Kersten M. Small, Stephen B. Liggett
  • Alpha-2 adrenergic receptor polymorphisms
    Publication number: 20030113725
    Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2B, alpha-2A, and alpha-2C adrenergic receptor and expressed alpha-2B, alpha-2A and alpha-2C adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system disease.
    Type: Application
    Filed: November 1, 2001
    Publication date: June 19, 2003
    Inventors: Kersten M. Small, Stephen B. Liggett