Patents by Inventor Kerstin Hein

Kerstin Hein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducible AAV REP genes
    Patent number: 12060569
    Abstract: The present invention relates to host cells comprising a nucleic acid encoding Adeno-associated virus (AAV) Rep proteins Rep78 and Rep68, wherein the internal AAV promoter p19 has been inactivated by one or more mutations that maintain the functionality of said Rep78 and Rep68 proteins. The present invention further relates to respective nucleic acids and vectors comprising the same, as well as respective methods for the production of AAV.
    Type: Grant
    Filed: April 17, 2023
    Date of Patent: August 13, 2024
    Assignee: Cevec Pharmaceuticals, GmbH
    Inventors: Kerstin Hein, Nicole Faust, Silke Wissing
  • Inducible AAV REP genes
    Publication number: 20230348936
    Abstract: The present invention relates to host cells comprising a nucleic acid encoding Adeno-associated virus (AAV) Rep proteins Rep78 and Rep68, wherein the internal AAV promoter p19 has been inactivated by one or more mutations that maintain the functionality of said Rep78 and Rep68 proteins. The present invention further relates to respective nucleic acids and vectors comprising the same, as well as respective methods for the production of AAV.
    Type: Application
    Filed: April 17, 2023
    Publication date: November 2, 2023
    Applicant: Cevec Pharmaceuticals, GmbH
    Inventors: Kerstin Hein, Nicole Faust, Silke Wissing
  • Inducible AAV Rep genes
    Patent number: 11685932
    Abstract: The present invention relates to host cells comprising a nucleic acid encoding Adeno-associated virus (AAV) Rep proteins Rep78 and Rep68, wherein the internal AAV promoter p19 has been inactivated by one or more mutations that maintain the functionality of said Rep78 and Rep68 proteins. The present invention further relates to respective nucleic acids and vectors comprising the same, as well as respective methods for the production of AAV.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: June 27, 2023
    Assignee: Cevec Pharmaceuticals, GmbH
    Inventors: Kerstin Hein, Nicole Faust, Silke Wissing
  • Inducible AAV REP genes
    Publication number: 20200277628
    Abstract: The present invention relates to host cells comprising a nucleic acid encoding Adeno-associated virus (AAV) Rep proteins Rep78 and Rep68, wherein the internal AAV promoter p19 has been inactivated by one or more mutations that maintain the functionality of said Rep78 and Rep68 proteins. The present invention further relates to respective nucleic acids and vectors comprising the same, as well as respective methods for the production of AAV.
    Type: Application
    Filed: September 18, 2018
    Publication date: September 3, 2020
    Applicant: Cevec Pharmaceuticals, GmbH
    Inventors: Kerstin Hein, Nicole Faust, Silke Wissing