Patents by Inventor Kerstin Lindblad-Toh

Kerstin Lindblad-Toh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF TREATING MUSCULAR DYSTROPHY
    Publication number: 20170224758
    Abstract: Provided herein are compositions and methods of treating muscular dystrophy (MD), such as administering an effective amount of a composition that increases the expression of JAG1, a composition comprising a JAG1 agonist, or a composition that promotes JAG1 signaling. Also provided are methods of prognosing MD or evaluating responsiveness to treatment for MD, e.g., by measuring an expression level of JAG1, and methods of identifying a compound for the treatment of MD.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 10, 2017
    Applicants: THE BROAD INSTITUTE, INC., CHILDREN'S MEDICAL CENTER CORPORATION, UNIVERSITY OF SAO PAULO
    Inventors: KERSTIN LINDBLAD-TOH, LOUIS M. KUNKEL, NATASSIA M. VIEIRA, MAYANA ZATZ
  • SLE AND SLE-RELATED DISEASE-ASSOCIATED RISK MARKERS AND USES THEREOF
    Publication number: 20160060699
    Abstract: Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing systemic lupus erythematosus (SLE) or an SLE-related immune-mediated rheumatic disorder or having undiagnosed SLE or an SLE-related immune-mediated rheumatic disorder. These subjects are identified based on the presence of gem-line risk markers.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 3, 2016
    Applicant: The Broad Institute, Inc.
    Inventors: Göran Andersson, Helene Hansson-Hamlin, Sergey Kozyrev, Kerstin Lindblad-Toh, Maria Wilbe
  • OSTEOSARCOMA-ASSOCIATED RISK MARKERS AND USES THEREOF
    Publication number: 20160024588
    Abstract: Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing cancer or having an undiagnosed osteosarcoma. These subjects are identified based on the presence of germ-line risk markers.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Elinor Karlsson, Kerstin Lindblad-Toh, Snaevar Sigurdsson, Emma Ivansson
  • METHODS FOR ASSESSING THE RISK OF CANINE ATOPIC DERMATITIS
    Publication number: 20150376702
    Abstract: The present invention relates to methods for assessing the risk of a dog to develop canine atopic dermatitis. The methods comprise detecting in a sample of DNA obtained from a dog the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on dog (Canis familiaris) chromosome 27, said marker being associated with an increased risk of developing canine atopic dermatitis.
    Type: Application
    Filed: February 21, 2014
    Publication date: December 31, 2015
    Applicants: BIOCISTRONIX AB, THE BROAD INSTITUTE, INC.
    Inventors: Goran ANDERSSON, Kerstin BERGVALL, Ake HEDHAMMER, Marcin KIERCZAK, Katarina TENGVALL, Kerstin LINDBLAD-TOH
  • CANCER-ASSOCIATED GERM-LINE AND SOMATIC MARKERS AND USES THEREOF
    Publication number: 20150299795
    Abstract: The invention provides methods and compositions for identifying subjects, including canine subjects, having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects are identified based on the presence of germ-line allele(s) and markers and various somatic mutations.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 22, 2015
    Applicants: The Broad Institute, Inc., Trustees of Tufts College, North Carolina State University, Regents of the University of Minnesota
    Inventors: Kerstin Lindblad-Toh, Noriko Tonomura, Evan Mauceli, Jaime Modiano, Matthew Breen
  • NEUROPSYCHIATRIC DISORDER-ASSOCIATED MUTATIONS AND USES THEREOF
    Publication number: 20150211067
    Abstract: Provided herein are methods and compositions for identifying subjects as having an elevated risk of developing or having a neuropsychiatric disorder. These subjects are identified based on the presence of one or more mutations.
    Type: Application
    Filed: January 26, 2015
    Publication date: July 30, 2015
    Inventors: Kerstin Lindblad-Toh, Elinor Karlsson, Hyun Ji Noh, Guoping Feng, Ruqi Tang
  • GENETIC RISK ASSESSMENT FOR SHAR-PEI FEVER
    Publication number: 20120021928
    Abstract: The present invention provides genetic tests for the copy number or a duplication of an upstream element of the Hyaluronic Acid Synthase 2 (HAS2) gene on chromosome 13 in Shar-Pei dogs to assess risk for a Shar-Pei dog to develop Shar-Pei fever. As Shar-Pei fever is a serious disease, and its chronic state involves a high risk of developing systemic amyloidosis and kidney failure, a genetic test for the copy number of the duplication will be useful in Shar-Pei breeding. Also provided are probes and primer pairs for use in these methods.
    Type: Application
    Filed: June 15, 2011
    Publication date: January 26, 2012
    Inventors: Kerstin Lindblad-Toh, Mia Olsson, Linda Tintle
  • PREDICTION AND DIAGNOSIS OF CANINE DEGENERATIVE MYELOPATHY
    Publication number: 20090239225
    Abstract: The present invention provides for methods of identifying a dog carrying a major genetic risk factor in the SOD1 gene for degenerative myelopathy, a potential model for human amyeotrophic lateral sclerosis. Also provided a methods of early diagnosis, treatment and breeding based on the presence or absence of the marker.
    Type: Application
    Filed: February 4, 2009
    Publication date: September 24, 2009
    Inventors: Joan R. Coates, Kerstin Lindblad-Toh, Claire Wade, Gary S. Johnson
  • Diagnostic method
    Publication number: 20090235371
    Abstract: The present invention relates to a method of diagnosing or detecting cone-rod dystrophy in a mammal, particularly in a canine species. In particular, the invention relates to methods involving the detection of a deletion in the NPHP4 (nephroretinin 4) gene and associated biomarkers. The invention also provides primers, nucleic acid molecules, polypeptides, antibodies, as well as kits for use in such methods.
    Type: Application
    Filed: December 3, 2008
    Publication date: September 17, 2009
    Inventors: Frode Lingaas, Anne Caroline Wiik, Claire Margaret Wade, Kerstin Lindblad-Toh
  • Methods for selecting primers
    Patent number: 6440675
    Abstract: Methods for selecting primers having a reduced incidence of undesirable interactions are disclosed. Methods of improving the accuracy of SBE-fluorescence polarization (SBE-FP) methods are also disclosed.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: August 27, 2002
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Kerstin A. Lindblad-Toh, Ellen Winchester, Joel N. Hirschhorn, Pamela Sklar