Abstract: The invention is to provide a method of profiling a sample comprising a plurality of cells, the method comprising: flowing cells from the sample through a first array of pillars to obtain one or more distribution profiles of cells sorted by the first array; flowing cells from the sample through a second array of pillars that is different from the first array of pillars to obtain on one or more distribution profiles of cells sorted by the second array; and deriving a biophysical signature of the sample based on at least the one or more distribution profiles of the cells sorted by the first array and/or the one or more distribution profiles of the cells sorted by the second array. The method further comprises determining a health status of a subject based on the biophysical signature of the sample. The invention is also to provide a sample profiling system.

Abstract: Devices and methods for microfluidic parallel sample processing are described. According to an embodiment a microfluidic system for parallel sample processing is provided. The microfluidic system comprises one or more modules, each module comprising: one or more microfluidic chips arranged in a microfluidic chip stack, each of the one or more microfluidic chips comprising a plurality of processing channels, each processing channel comprising an inlet, an outlet, and a processing section, a combined sample inlet fluidically coupled to each processing channel inlet and configured to concatenate a plurality of the processing channel inlets, and a combined sample outlet fluidically coupled to each processing channel outlet and configured to concatenate a plurality of the processing channel outlets.

Abstract: The invention is to provide a method of profiling a sample comprising a plurality of cells, the method comprising: flowing cells from the sample through a first array of pillars to obtain one or more distribution profiles of cells sorted by the first array; flowing cells from the sample through a second array of pillars that is different from the first array of pillars to obtain on one or more distribution profiles of cells sorted by the second array; and deriving a biophysical signature of the sample based on at least the one or more distribution profiles of the cells sorted by the first array and/or the one or more distribution profiles of the cells sorted by the second array. The method further comprises determining a health status of a subject based on the biophysical signature of the sample. The invention is also to provide a sample profiling system.