Patents by Inventor Kesang Li

Kesang Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric antigen receptors targeting GPC3 and uses thereof
    Patent number: 10731127
    Abstract: A nucleic acid encoding a chimeric antigen receptor expressed at surface of a T lymphocyte, said chimeric antigen receptor comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody, scFv(GPC3), which specifically recognizes the C-terminal epitope of GPC3. A genetically modified T lymphocyte having a chimeric antigen receptor expressed at surface thereof, and the chimeric antigen receptor is expressed by the nucleic acid described above.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: August 4, 2020
    Assignee: CARsgen Therapeutics Limited
    Inventors: Zonghai Li, Huiping Gao, Hua Jiang, Bizhi Shi, Huamao Wang, Kesang Li, Hongyang Wang, Shengli Yang, Jianren Gu
  • Nucleic Acid Of Coded GPC3 Chimeric Antigen Receptor Protein And T Lymphocyte Expressing GPC3 Chimeric Antigen Receptor Protein
    Publication number: 20160215261
    Abstract: A nucleic acid encoding a chimeric antigen receptor expressed at surface of a T lymphocyte, said chimeric antigen receptor comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody, scFv(GPC3), which specifically recognizes the C-terminal epitope of GPC3. A genetically modified T lymphocyte having a chimeric antigen receptor expressed at surface thereof, and the chimeric antigen receptor is expressed by the nucleic acid described above.
    Type: Application
    Filed: May 6, 2014
    Publication date: July 28, 2016
    Inventors: Zonghai Li, Huiping Gao, Hua Jiang, Bizhi Shi, Huamao Wang, Kesang Li, Hongyang Wang, Shengli Yang, Jianren Gu