Patents by Inventor Keshab Sarma

Keshab Sarma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing 4'-azido-nucleoside derivatives
    Publication number: 20050038240
    Abstract: A process for the preparation of a 4?-azido-2?,3?,5?-triacyl-nucleoside compound (I; B=B1; R1 is R1aCO— and R2 is R2aCO—) or a 4?-azidonucleoside compounds (I; B is B1 or B2 and R1 and R2 are hydrogen and acid addition salts thereof) wherein R1a and R2a are independently C1-10 alkyl or phenyl optionally substituted with 1 to 3 substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro or cyano and R3 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-3 haloalkyl and halogen, comprising contacting a 5?-iodo compound II with a peracid, R2aC(O)OOH, an acid R2aC(O)OH and a phase transfer catalyst and interconverting a uridine B1 to a cytosine B2. The present process provides the 4?-azidonucleosides safely and selectively in high purity with increased efficiency.
    Type: Application
    Filed: June 18, 2004
    Publication date: February 17, 2005
    Inventors: Terrence Connolly, Kieran Durkin, Keshab Sarma, Jiang Zhu
  • Antiviral nucleoside derivatives
    Patent number: 6846810
    Abstract: The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: January 25, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Joseph Armstrong Martin, Keshab Sarma, David Bernard Smith, Mark Smith
  • Novel anhydrous crystalline 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine hemisulfate as useful as an antiviral agent
    Publication number: 20040162265
    Abstract: The present invention relates to the hemisulfate salt of 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine (Ia) with improved stability and physical properties which facilitate manufacturing, handling and formulating I and polymorphic crystalline forms thereof.
    Type: Application
    Filed: December 9, 2003
    Publication date: August 19, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Terrence Joseph Connolly, Joseph Armstrong Martin, Anthony Prince, Keshab Sarma
  • Antiviral nucleoside derivatives
    Publication number: 20040121969
    Abstract: The present invention relates to nucleosides of formula I wherein R1, R2 and R3 are as defined herein that modulateTh1 and Th2 immune activity, methods of using compounds according to formula I, alone or in combination therapy, for treatment of a bacterial or a viral infection, a parasite infestation, a cancer or tumor or an autoimmune disease and compositions containing prodrugs of the nucleoside of formula Ia.
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Robert Than Hendricks, Eric Roy Humphreys, Joseph Armstrong Martin, Anthony Prince, Keshab Sarma
  • Antiviral nucleoside derivatives
    Publication number: 20040121980
    Abstract: The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy.
    Type: Application
    Filed: November 19, 2003
    Publication date: June 24, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Joseph Armstrong Martin, Keshab Sarma, David Bernard Smith, Mark Smith
  • Matrix metalloprotease inhibitors
    Patent number: 5932595
    Abstract: The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: August 3, 1999
    Assignees: Syntex (U.S.A.) Inc., Agouron Pharmaceuticals, Inc.
    Inventors: Steven Lee Bender, Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Lawrence Emerson Fisher, Robert Than Hendricks, Keshab Sarma