Patents by Inventor Kesheng Dai

Kesheng Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR
    Publication number: 20220313719
    Abstract: A method of treating diseases associated with changes in platelet counts and a method for inhibiting and promoting platelet apoptosis using protein kinase a activator and inhibitor are provided. Protein kinase A regulates platelet apoptosis by means of regulating the phosphorylation of serine at BAD position 155; the activation of protein kinase A activity may inhibit the occurrence of endogenous platelet apoptosis, and may also increase circulating platelet counts in experimental animals; in addition, inhibiting PKA activity may induce platelet apoptosis in vitro, while also reducing circulating platelet counts in the body, indicating that PKA inhibitors may participate in the treatment of thrombocytosis, and reduce platelet counts in peripheral circulating blood.
    Type: Application
    Filed: April 25, 2022
    Publication date: October 6, 2022
    Applicant: Soochow university
    Inventor: Kesheng DAI
  • METHOD OF USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR IN PREPARATION OF DRUGS FOR TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS AND FOR INHIBITING AND PROMOTING PLATELET APOPTOSIS
    Publication number: 20190343861
    Abstract: A method of using protein kinase A (PKA) activator and inhibitor in preparations of drugs for treating diseases associated with changes in platelet counts. Protein kinase A regulates platelet apoptosis by means of regulating the phosphorylation of serine at BAD position 155; the activation of protein kinase A activity may inhibit the occurrence of endogenous platelet apoptosis, and may also increase circulating platelet counts in experimental animals; in addition, inhibiting PKA activity may induce platelet apoptosis in vitro, while also reducing circulating platelet counts in the body, indicating that PKA inhibitors may participate in the treatment of thrombocytosis, and reduce platelet counts in peripheral circulating blood.
    Type: Application
    Filed: July 24, 2019
    Publication date: November 14, 2019
    Applicant: Soochow university
    Inventor: Kesheng DAI
  • Methods and compositions for the inhibition of thrombus formation
    Patent number: 8173595
    Abstract: The present invention is directed to anti-platelet peptides that may be used in various methods for the treatment or prophylaxis of thrombosis. More specifically, the specification describes methods and compositions for making and using compositions GPIb? fragments as anti-platelet agents. The present invention is also directed to peptides that inhibit intracellular function of 14-3-3.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: May 8, 2012
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kesheng Dai, Xiaoping Du
  • Methods and Compositions for the Inhibition of Thrombus Formation
    Publication number: 20080293628
    Abstract: The present invention is directed to anti-platelet peptides that may be used in various methods for the treatment or prophylaxis of thrombosis. More specifically, the specification describes methods and compositions for making and using compositions GPIb? fragments as anti-platelet agents. The present invention is also directed to peptides that inhibit intracellular function of 14-3-3.
    Type: Application
    Filed: April 27, 2005
    Publication date: November 27, 2008
    Inventors: Kesheng Dai, Xiaoping Du