Patents by Inventor Kestutis Sasnauskas

Kestutis Sasnauskas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of native recombinant secreted human endoplasmic reticulum chaperones by using their native signal sequences in yeast expression systems
    Patent number: 9796971
    Abstract: A method using yeast as a host for production of human ER chaperone proteins, using endogenous signal peptides of intracellular human proteins that are recognized and correctly processed in the yeast cells to subsequently lead to the secretion of the human proteins. The resultant proteins possessed native amino acid sequence and were biologically active. Moreover, secretion allowed simple one-step purification of native recombinant human proteins with high yields.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: October 24, 2017
    Assignee: UAB BALTYMAS
    Inventors: Evaldas Ciplys, Rimantas Slibinskas, Kestutis Sasnauskas, Marek Michalak, Leslie Ina Gold
  • Generation of Native Recombinant Secreted Human Endoplasmic Reticulum Chaperones by Using Their Native Signal Sequences in Yeast Expression Systems
    Publication number: 20150191713
    Abstract: A method using yeast as a host for production of human ER chaperone proteins, using endogenous signal peptides of intracellular human proteins that are recognized and correctly processed in the yeast cells to subsequently lead to the secretion of the human proteins. The resultant proteins possessed native amino acid sequence and were biologically active. Moreover, secretion allowed simple one-step purification of native recombinant human proteins with high yields.
    Type: Application
    Filed: January 12, 2015
    Publication date: July 9, 2015
    Applicant: UAB BALTYMAS
    Inventors: Evaldas Ciplys, Rimantas Slibinskas, Kestutis Sasnauskas, Marek Michalak, Leslie Ina Gold
  • Process for the production of monoclonal antibodies
    Patent number: 7919314
    Abstract: Provided is a use of a recombinant chimaeric protein as an immunogen in a process for producing a monoclonal antibody, wherein the recombinant chimaeric protein is assembled into a virus-like particles, and includes a foreign protein or peptide or a fragment thereof.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: April 5, 2011
    Assignee: Biotechnologijos Institutas
    Inventors: Aurelija Zvirbliene, Alma Gedvilaite, Rainer Ulrich, Kestutis Sasnauskas
  • Process for the production of monoclonal antibodies
    Publication number: 20090269371
    Abstract: Provided is a use of a recombinant chimaeric protein as an immunogen in a process for producing a monoclonal antibody, wherein the recombinant chimaeric protein is assembled into a virus-like particles, and includes a foreign protein or peptide or a fragment thereof.
    Type: Application
    Filed: October 12, 2007
    Publication date: October 29, 2009
    Inventors: Aurelija Zvirbliene, Alma Gedvilaite, Rainer Ulrich, Kestutis Sasnauskas
  • Regulatory sequences and expression cassettes for yeasts, especially for kluyveromyces
    Patent number: 7132522
    Abstract: The invention relates to a DNA sequence which acts as a promoter in yeast cells, to an expression and optionally, secretion system containing said DNA sequence, to plasmids containing this system, to host cells that have been transformed with said DNA and to methods for producing proteins and polypeptides.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: November 7, 2006
    Assignee: TAD Pharma GmbH
    Inventors: Dietmar Becher, Rimantas Siekstele, Danguole Bartkeviciute, Kestutis Sasnauskas, Leopold Döhner, Salah Salim
  • Dna sequence comprising regulatory regions for expressing proteins
    Publication number: 20040161841
    Abstract: Described is a DNA sequence which includes the triosephosphate isomerase gene including its regulatory sequences, a DNA sequence which is active as a promoter, expression and secretion systems containing said sequence and the use thereof and a process for producing proteins.
    Type: Application
    Filed: February 2, 2004
    Publication date: August 19, 2004
    Inventors: Leopold Dohner, Dietmar Becher, Salah Salim, Rimantas Siekstele, Kestutis Sasnauskas