Patents by Inventor Kesuo Fan

Kesuo Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ETAR ANTIBODY, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
    Publication number: 20230346932
    Abstract: Provided herein are a stable solution formulation of an ETAR antibody, and use thereof in treating, preventing, or alleviating one or more symptoms of pulmonary arterial hypertension or one or more symptoms of cancer of a reproductive organ.
    Type: Application
    Filed: January 17, 2023
    Publication date: November 2, 2023
    Applicant: Gmax Biopharm LLC.
    Inventors: Cheng Zhang, Kesuo Fan, Yong Guo, Chenjiang Yao, Hua Zhang, Xiaofeng Wang, Shuqian Jing
  • Stable pharmaceutical solution formulation of GLP-1R antibody fusion protein
    Patent number: 10485870
    Abstract: Disclosed is a stable pharmaceutical solution formulation of a GLP-1R antibody fusion protein, comprising a therapeutically effective amount of the GLP-1R antibody fusion protein, an amino acid, a surfactant and a buffer system. The final concentration of the amino acid is 1-500 mM, the final concentration of the surfactant is 0.01%-0.5%, and the pH value of the stable solution formulation is from 5.0 to 8.0. The stable solution formulation of the present invention can be used in the treatment of diabetes, obesity and conditions associated therewith.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: November 26, 2019
    Assignee: Gmax Biopharm LLC.
    Inventors: Cheng Zhang, Hua Zhang, Kesuo Fan, Yong Guo, Shuqian Jing
  • ETAR ANTIBODY, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
    Publication number: 20190134196
    Abstract: Provided herein are a stable solution formulation of an ETAR antibody, and use thereof in treating, preventing, or alleviating one or more symptoms of pulmonary arterial hypertension or one or more symptoms of cancer of a reproductive organ.
    Type: Application
    Filed: May 27, 2017
    Publication date: May 9, 2019
    Inventors: Cheng Zhang, Kesuo Fan, Yong Guo, Chenjiang Yao, Hua Zhang, Xiaofeng Wang, Shuqian Jing
  • Stable Pharmaceutical Solution Formulation of GLP-1R Antibody Fusion Protein
    Publication number: 20180000934
    Abstract: Disclosed is a stable pharmaceutical solution formulation of a GLP-1R antibody fusion protein, comprising a therapeutically effective amount of the GLP-1R antibody fusion protein, an amino acid, a surfactant and a buffer system. The final concentration of the amino acid is 1-500 mM, the final concentration of the surfactant is 0.01%-0.5%, and the pH value of the stable solution formulation is from 5.0 to 8.0. The stable solution formulation of the present invention can be used in the treatment of diabetes, obesity and conditions associated therewith.
    Type: Application
    Filed: February 3, 2016
    Publication date: January 4, 2018
    Inventors: Cheng Zhang, Hua Zhang, Kesuo Fan, Yong Guo, Shuqian Jing
  • Construction and application of bispecific antibody EpCAM×CD3
    Patent number: 9777073
    Abstract: The present invention provides a bispecific antibody. The bispecific antibody provided by the present invention comprises a single-chain unit and a monovalent unit, wherein the single-chain unit has a specific binding capability against surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability against the surface antigen EpCAM of a tumor cell; the single-chain unit comprises a single-chain variable fragment ScFv fused with an Fc fragment; and the monovalent unit comprises a light chain and heavy chain pair. The present invention also provides a preparation method of the bispecific antibody and pharmaceutical use of these antibodies.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: October 3, 2017
    Assignee: Wuhan YZY Biopharma Co., Ltd.
    Inventors: Pengfei Zhou, Tao Wang, Lijuan Fang, Liu Hu, Yang Liu, Yu Zhang, Kesuo Fan
  • Construction and application of bispecific antibody EpCAMxCD3
    Publication number: 20160090426
    Abstract: The present invention provides a bispecific antibody. The bispecific antibody provided by the present invention comprises a single-chain unit and a monovalent unit, wherein the single-chain unit has a specific binding capability against surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability against the surface antigen EpCAM of a tumor cell; the single-chain unit comprises a single-chain variable fragment ScFv fused with an Fc fragment; and the monovalent unit comprises a light chain and heavy chain pair. The present invention also provides a preparation method of the bispecific antibody and pharmaceutical use of these antibodies.
    Type: Application
    Filed: July 20, 2015
    Publication date: March 31, 2016
    Inventors: Pengfei Zhou, Tao Wang, Lijuan Fang, Liu Hu, Yang Liu, Yu Zhang, Kesuo Fan
  • Alpha-amylase assay and uses thereof
    Publication number: 20060141542
    Abstract: This invention relates to methods and kits for measuring ?-amylase activity in samples such as flour, stock, or amylase concentrate.
    Type: Application
    Filed: August 18, 2003
    Publication date: June 29, 2006
    Inventors: Barb Cohen, Stephen Powers, Kesuo Fan