Abstract: A system and method for dental image file capture and manipulation for the purpose of dental, orthodontic, and periodontic tracking, diagnostics, and dental prosthetic and implant design. Augmented intelligence in dental file segmentation using descriptor matrixes with a common centroid or reference locus as a reference point describing related dental surface structures reduces the data size of dental image files such that dental images can be manipulated and compared to other dental files and can be used in machine learning and matching systems. This expedites the design and manufacture of dental prosthetics, appliances, and in dental monitoring and treatment.

Abstract: A continuous process for preparing a solid lipid nanoparticle of ibuprofen utilizing hot melt extrusion which avoids additional steps such as high-pressure homogenization, ultrasonication, or solvent evaporation. The continuous process includes preparing a pre-emulsion comprising a lipid, and continuously processing the pre-emulsion through a hot melt extruder device.

Abstract: A solid self-micro/nano emulsifying formulation comprising CARP-1 functional mimetics (CFM; e.g., CFM-4.16 or CFM-4.17) for oral administration, and methods of fabrication and use thereof to treat cancer (e.g., breast cancer, triple negative breast cancer, resistant lung cancer, and non-resistant lung cancer) and reduce tumor volume. Solid self-micro/nano emulsifying formulation of CFM compounds was found to have significantly enhanced drug loading, aqueous solubility, and oral bioavailability of the formulation.

Abstract: A solid self-micro/nano emulsifying formulation comprising CARP-1 functional mimetics (CFM; e.g., CFM-4.16 or CFM-4.17) for oral administration, and methods of fabrication and use thereof to treat cancer (e.g., breast cancer, triple negative breast cancer, resistant lung cancer, and non-resistant lung cancer) and reduce tumor volume. Solid self-micro/nano emulsifying formulation of CFM compounds was found to have significantly enhanced drug loading, aqueous solubility, and oral bioavailability of the formulation.

Abstract: A pharmaceutical formulation and topical administration thereof for the treatment of psoriasis or any one or more symptoms associated therewith. The formulation contains a therapeutically effective amount pemetrexed alone as the active agent or can contain therapeutically effective amounts of pemetrexed in combination with siRNA-inhibiting TNF?. The formulation may further include a cationic surfactant, such as cetylpyridinum chloride, and urea for enhanced permeation through the stratum corneum of the patient or subject.

Abstract: In an embodiment, the current invention is a composition for oral or parenteral administrable taxane to treat cancer in human patients, comprising orally or parenterally co-administering to said patient a taxane comprising a derivative, an analog or a prodrug of paclitaxel or docetaxel, and bioavailability and efficacy enhancing agent comprising a piperlongumine. The present invention relates in its principal aspect to the oral or parenteral administration of one or a combination of taxanes to human patients suffering from cancer. In another embodiment, the current invention is a method of increasing the bioavailability of taxanes, which are poorly absorbed or not absorbed at all from the gastrointestinal tract or gut, by pre-administering and/or simultaneously administering to a human subject orally or parenterally one or a combination of agents (“enhancing agents”) effective in enhancing bioavailability by inhibiting CYP3A4 enzyme.

Abstract: Transformer driven by data modulated signal provides isolated power. Outbound data is extracted from the data modulated signal received from the transformer. Inbound data received in isolated circuitry modulates the load presented to transformer. Inbound data perceived in non-isolated circuitry by sensing load experienced by the transformer.