Abstract: The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone.

Abstract: According to an embodiment of the present disclosure, there is provided a hydro crusher for water treatment, for removing living organisms from water to be treated, the hydro crusher including: a body portion which has a cylindrical shape having an inner space, and includes an inflow portion to allow the water to be treated to be drawn into the inner space therethrough, and a discharge portion to discharge the water to be treated, drawn in through the inflow portion; and solid particles which are movable by the water to be treated, wherein the movable solid particles are filled in at least a portion of the inner space.

Abstract: According to an embodiment of the present disclosure, there is provided a hydro crusher for water treatment, for removing living organisms from water to be treated, the hydro crusher including: a body portion which has a cylindrical shape having an inner space, and includes an inflow portion to allow the water to be treated to be drawn into the inner space therethrough, and a discharge portion to discharge the water to be treated, drawn in through the inflow portion; and solid particles which are movable by the water to be treated, wherein the movable solid particles are filled in at least a portion of the inner space. Accordingly, there is an effect that physical sterilization is possible by killing or inactivating living organism included in water to be treated by applying a shock to the living organism.