Abstract: A technique for preparing a nanoplatform-based tumor-targeted diagnostic contrast agent which enables precise local diagnosis of cancer lesions is provided. The nanoplatform-based tumor-targeted diagnostic contrast agent can avoid the situation in which normal tissue is unnecessarily excised or tumor tissue is not excised when tumor removal surgery is performed under fluorescence image guidance, and can be visualized by emitting light under near-infrared ray induction as the contrast agent is directly applied to the local area and then quickly and accurately penetrates/is absorbed into the cancer lesion so that a clinical surgeon efficiently and conveniently performs surgery in an operating room during laparoscopic surgery with minimal incision or open surgery according to the occurrence site and progression of cancer.

Abstract: The present invention relates to a method for preparing a nano diagnostic agent capable of selective staining of abnormal inflammatory tissues or tumor tissues. The method for preparing a nano diagnostic agent, according to the present invention, is characterized by comprising: a step of forming a first mixture by mixing polysorbate 80, soybean oil, and a water-insoluble staining material; a step of forming a second mixture by mixing and then heating the first mixture and a triblock copolymer; a step of forming a nano platform solid by cooling the second mixture; a step of forming a third mixture by mixing a solvent with the nano platform solid; a step of removing impurities from the third mixture; and a step of forming a nano-composite by freeze-drying the third mixture from which the impurities are removed.

Abstract: The present disclosure relates to a temperature-sensitive nanoparticle/hydrogel complex, and more particularly, the temperature-sensitive nanoparticle/hydrogel complex for sustained-release drug release that can delay the drug release rate at the administration site, thereby maximizing the drug treatment efficacy at the local site by the interaction between the drug and the nanoparticles as well as the interaction between the drug and the hydrogel when mixing a drug-free nanoparticle/hydrogel complex and a predetermined drug.

Abstract: A method for preparing a nanoparticle/hydrogel composite for a drug carrier according to one embodiment of the present invention comprises the steps of: forming stabilized lipid-based nanoparticles by irradiating an ultrasonic wave on a mixture of phosphatidylcholine and polysorbate 80 and then mixing a first polymer and freeze-drying same; and forming a lipid-based nanoparticle/hydrogel composite by mixing a second polymer and hyaluronic acid with the lipid-based nanoparticles and freeze-drying same.

Abstract: Disclosed are biocompatible polymeric nanoparticles for drug delivery and a method for preparing the same. They can be prepared by mixing a tri-block copolymer, PEG, and a drug at a predetermined temperature to give a homogeneous polymeric mixture; solidifying the homogeneous polymeric mixture at room temperature; and dissolving the solidified polymeric mixture in an aqueous solution. Based on a polymer melting process, the method makes it easy to produce poloxamer nanoparticles at low cost. The nanoparticles show desired particle sizes suitable for use in drug delivery and a uniform particle size distribution. Consisting of a bilayer structure, the nanoparticles can contain sparingly soluble drugs. Also, the nanoparticles contain no organic solvents and are thus safe to the body because they are free of organic solvent residuals.

Abstract: The present invention relates to an application of stabilized nanoparticles with a lipid core and shell structures as protein drug carriers, wherein the nanoparticles are prepared by producing nano-sized particles from lecithin obtained from natural soybean, and then adsorbing polaxamer thereon. Here, lecithin is used as an ingredient of core structure, polaxamer is used as an ingredient of shell structure, and both ingredients are applicable to a human body. Thus-obtained nanoparticles having a lipid core and shell structures are applicable in the clinical application. Moreover, said nanoparticles are suitable for use as a drug carrier or a diagnostic agent because they are produced in an aqueous solution without organic solvents.