Abstract: A rope wrench comprising or including a base plate having a lever arm at one end and a lever handle opposite the lever arm, a pair of bollards at the lever arm end for receiving therebetween an anchored climbing rope, and a gate spaced from the back plate and pivotable about one of the bollards, thereby permitting mid-rope access to the bollards when open and preventing mid-rope detachment when closed, the arrangement being such that when the gate is closed and the lever arm is rotated by the handle about the major axis of one of the bollards they collectively cause the rope to assume a serpentine shape to shorten the effective length of the main rope and assist ascent by the climber or to impart friction to the rope when descending whereby to permit controlled descent.

Abstract: A check valve having a through-flow grooved poppet is provided in which the poppet includes a plurality of helically-oriented grooves around the exterior surface of the poppet, as well as a set of poppet apertures. When the check valve is displaced from a closed position, fluid flows from a first port to a second port by passing through both the set of poppet apertures and the plurality of helically-oriented groves positioned on the exterior of the poppet. The poppet thus provides multiple flow paths which improves the performance of the check valve by reducing the pressure drop upon activation.

Abstract: A method of treating or alleviating at least one symptom of a coronavirus infection in a subject, by administering to the subject a therapeutically effective amount of an RNA polymerase inhibitor. In some embodiments, the symptom is selected from the group consisting of fever, cough, tiredness, sore throat, diarrhea, conjunctivitis, headache, loss of taste, loss of smell, rash, difficulty breathing, shortness of breath, chest pain, chest pressure, Acute Respiratory Distress Syndrome (ARDS) and organ failure.

Abstract: The present invention is directed to generating structured text document from the output of a query for compounds using a n-dimensional map where the n-dimensional map includes an arrangement of biological or chemical entities enumerated within a collection of documents describing a particular biological target of interest.

Abstract: A method in a reconfigurable computing system includes connecting a plurality of tensor consumers to their corresponding tensor producers via skip-buffers, which generates a plurality of skip-buffers. The method includes determining that at least one skip-buffer of the plurality of skip-buffers corresponding to a first set of tensor consumers and at least one skip-buffer of the plurality of skip-buffers corresponding to a second set of tensor consumers, are compatible to wholly or partially merge. The method also includes merging, wholly or partially, the compatible skip-buffers to produce a merged skip-buffer having a minimal buffer depth. The described method may reduce memory unit consumption and latency.

Abstract: A method for merging buffers and associated operations includes receiving a compute graph for a reconfigurable dataflow computing system and conducting a buffer allocation and merging process responsive to determining that a first operation specified by a first operation node is a memory indexing operation and that the first operation node is a producer for exactly one consuming node that specifies a second operation. The buffer allocation and merging process may include replacing the first operation node and the consuming node with a merged buffer node within the graph responsive to determining that the first operation and the second operation can be merged into a merged indexing operation and that the resource cost of the merged node is less than the sum of the resource costs of separate buffer nodes. A corresponding system and computer readable medium are also disclosed herein.

Abstract: A radiotherapy device, a method and a computer readable medium are disclosed. The radiotherapy device includes a radiation source and a controller. The radiation source is configured to apply radiation to a subject. The controller is configured to determine an overlap between a defined volume of the subject and an isodose surface and to instruct the radiation source to halt application of the radiation based on the determination.

Abstract: The present disclosure relates to a method of reducing or arresting viral load in a subject infected with a coronavirus, the method comprising the step of administering to the subject a therapeutically effective amount of a viral protease inhibitor. In some embodiments, the subject is a human. In one embodiment, the coronavirus is SARS-COV-19 and the viral protease inhibitor is E)-N-(4-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide; (R)-3-((2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-phenylbutanoyl)-5,5-dimethyl-N-(2-methylbenzyl)thiazolidine-4-carboxamide; R)—N-allyl-3-((2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-phenylbutanoyl)-5,5-dimethylthiazolidine-4-carboxamide; (4-((N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)methyl)-2-fluorophenyl)boronic acid or salts thereof.

Abstract: The present invention is directed to generating an n-dimensional map using the results of a query for compounds enumerated within a collection of documents describing a particular biological target of interest and a curated set of compounds not enumerated in the collection of documents. Both sets of compounds (document coded and curated coded) are converted into coded forms and placed in the n-dimensional map. One or more processors are configured to evaluate the distance between the curated coded forms and the closest cluster of document coded forms. Based on the distance between a coded form and the document coded forms, the curated coded forms can be ranked regarding the likelihood of interacting with the particular biological target.

Abstract: A repository definition computer program may (1) retrieve repository data from data repositories; (2) identify a data repository structure for each data repository; (3) generating data repository definitions for the data repositories; (4) provide the data repository definitions in a data serialization language to a repository management system; and (5) generate a hash of each file in the data repositories and save a copy of each file named its hash. A UAT management system computer program may (6) execute a repository extract process to repave one the data repositories with the hash-named files. The repository extract computer program may (7) retrieve the data repository definitions for the data repository being repaved from a repository management system server; (8) retrieve the hash-named files from object storage for the data repository being repaved; and (9) recreate the data repository from the data repository definitions using hard links to the hash-named files.

Abstract: In an approach for determining the date of planting of a crop growing in an agricultural field, a processor receives an aerial image of one or more agricultural fields in a pre-determined geographical region. A processor selects a plurality of points from the aerial image. A processor calculates a Vegetation Index of one or more crops growing at the plurality of points selected. A processor compares the Vegetation Index calculated for the one or more crops growing at the plurality of points selected to the Vegetation Index known for a plurality of historical reference signatures. A processor generates an actual signature. A processor cross-correlates the actual signature against the plurality of historical reference signatures to measure a degree of similarity. A processor identifies the one or more crops growing in the one or more agricultural fields in the pre-determined geographical region from the cross-correlation.

Abstract: A detection device for a radiotherapy apparatus is described. The detection device comprises an arrangement of detectors comprising a plurality of radiation detectors, each detector arranged and configured to detect a projection of a feature of a phantom at the respective detector when a beam of radiation is applied to the phantom, and output a measurement value based on the detected projection. The detection device further comprises a controller configured to receive the measurement values from the plurality of detectors and determine a position of the phantom in a first coordinate system based on the received measurement values.

Abstract: A descender (1) for controlling the descent of a climber down a rope (2) fixed to an anchor point (P), the descender comprising a primary rope-engaging means in the form of a cam lock (3) and associated rope entry guide (10), the camlock having a rope braking surface co-operable with the rope entry guide to partially or wholly lock the rope in response to movement of the rope, and handle means (9) to adjustably unlock the camlock to thereby wholly or partially release the rope and thereafter allow further descent from the anchor point, CHARACTERISED IN THAT the descender also includes a secondary rope engaging means (15) disposed in advance of the primary rope engaging means (3,10) and having an additional rope-engaging braking surface (16) adapted to, in use, selectively impart additional or alternative friction to the rope before it enters the primary rope-engaging means.

Abstract: A tether includes a length of rope with a primary loop at a midpoint for connection to a rope wrench, a pair of secondary loops remote from the primary loop, and a generally stiff but partially flexible rope cover between the primary and secondary loops, the rope cover being pre-curved along its length, the tether also including a tail-portion of the rope between the secondary loops and the rope cover, providing unrestricted 360° flexibility for the secondary loops, the rope cover sufficiently rigid to permit the handle end of the rope wrench to be pushed or pulled by hand and the rope cover retaining its curve to minimise the risk of a user's hand interfering with a hitch cord, and the tail portion of the tether is sufficiently flexible to withstand side-loads.

Abstract: A combination climbing apparatus (1) comprising or including a rope ascender (5) and a pulley block (6), the rope ascender having front (19) and rear (21) plates disposed in generally parallel relationship, a first swivel pin (11) being received within co-axial bores in the front and rear plates, about which pin the plates are swivelable with respect to each other, a cam lever (9) mounted on the first swivel pin between the front and rear plates, the cam lever being connected, directly or indirectly, to a climbing rope braking surface (10) on a cam between the front and rear plates, the cam lever being operable to trap the rope against the cam braking surface, the front and rear plates each including a second bore (22,23) remote from the major axis of the first swivel pin for receiving a second, removable, swivel pin (29), a pulley block releasably the ascender and pulley block may be selectively used in combination when required or separately when not.

Abstract: The present disclosure relates to methods of treating at least one symptom of a coronavirus infection, or preventing an acute inflammatory response, e.g., a cytokine storm in a coronavirus patient, in particular a SARS-CoV-19 patient, by administering an angiontensin converting enzyme-2 (ACE2) modulator.

Abstract: A sonar display comprises a processing element and a display. The processing element is configured to receive a first sonar electronic signal from a first sonar transducer, receive a second sonar electronic signal from a second sonar transducer, generate data for a first underwater image stream from the first sonar electronic signal and a second underwater image stream from the second sonar electronic signal. The display is configured to show at least one of the first underwater image stream having a first view derived from reflections of a first sonar beam, the second underwater image stream having a second view derived from reflections of a second sonar beam, and an indication of a position of the first sonar beam relative to the second sonar beam.

Abstract: The present invention relates to a wire gripper to aid in wire pulling and method of use, A gripper is inserted into an interior cavity. A base comprises an interior cavity and a threaded attachment. The gripper comprises more than one flexible finger. A wire receptacle is formed between the flexible fingers. The gripper slides into the interior cavity of the base. A collar is open at both the top and bottom end. A wire passes through the top end of the collar and slides into the wire receptacle. The wire is retained within the wire receptacle by fastening the base to the collar causing the flexible finger to apply retaining pressure to the wire preventing the wire from being removed from the wire grabber. A pulling tension is applied by an installer person to the wire grabber to pull the wire from a starting location to a destination location.

Abstract: The present disclosure relates to a phosphorus additive that is useful for stable cycling and storage of lithium ion cells at high temperatures, an electrolyte containing the phosphorus additive, and an electrochemical energy storage device containing the electrolyte.