Abstract: Disclosed is a method and composition for nutritional compositions containing glucosidase inhibitors, and more specifically Touchi Extract and its uses in the treatment of many disorders. These disorders include diabetes, hyperlipidemia, obesity, Metabolic syndrome/Syndrome X, COPD, malabsorption, Crohn's disease, diarrhea, constipation, irritable bowel syndrome, human immunodeficiency virus, cystic fibrosis, non-alcoholic steatohepatitis, polycystic ovarian syndrome including associate infertility, and erectile dysfunction. Further, glucosidase inhibitors, and more specifically Touchi Extract can be used to aid healing in critical care patients and for general wound healing. Additionally, glucosidase inhibitors, including Touchi Extract can be used to enhance athletic performance.

Abstract: Nutritional compositions having the potential to reduce metabolic acid load and methods of making and using the nutritional compositions are provided. In an embodiment, the present disclosure provides methods of selecting and administering nutritional compositions to patients. The methods may include modifications to calculating a metabolic acid potential of a nutritional composition, calculating a base content of a nutritional composition and subtracting the base content from the acid content to determine a potential renal acid load (“PRAL”) value. The present disclosure also provides computer implemented processes for predicting PRAL values.

Abstract: This application discloses methods for the preparation of L-amino acids, which comprises fermentation of a desired L-amino acid-producing bacteria in which at least the tal gene is amplified. In some embodiments, genes of the biosynthesis pathway of the desired L-amino acid are additionally amplified.

Abstract: Nutritional compositions and methods of making and using the nutritional compositions are provided. In a general embodiment, the present disclosure provides nutritional compositions having whey protein micelles and leucine. The nutritional compositions provide a sufficient amount of leucine to improve protein synthesis in humans, while also maintaining a low-viscosity fluid matrix and acceptable organoleptic properties.

Abstract: The invention provides methods for treating muscle loss in an individual. In one embodiment, the invention includes administering to an individual an effective amount of a branched chain amino acid (BCAA), a BCAA precursor, a BCAA metabolite, a BCAA-rich protein, a protein manipulated to enrich the BCAA content or any combination thereof. The invention further provides nutritional products for such administration, including orally-administrable nutritional products.

Abstract: Nutritional compositions and methods of making and using the nutritional compositions are provided. In a general embodiment, the present disclosure provides a nutritional composition including a high protein component and one or more exogenous nucleotides. The nutritional compositions can be specifically used to accelerate and improve wound healing in a mammal.

Abstract: Nutritional compositions and methods of using the nutritional compositions with exercise to attenuate the loss of functional status are provided. In a general embodiment, the present disclosure provides a nutritional composition including whey protein, and Vitamin D. The nutritional composition and exercise can be specifically used to attenuate the loss of functional status, especially in the elderly.

Abstract: A hammer assembly for a grand piano comprising: a hammer, a hammer shank, a tubular lever interface, and a moveable knuckle. A grand piano tubular lever interface comprises: a deep socket; a set of two hinge pin attachment holes; a void area; and a moveable knuckle visual location system. A moveable knuckle comprises: a spline; a resilient core; a synthetic buckskin wear surface, and a moveable knuckle visual location system. Novel hammer assembly allows for a direct lever relationship between hammer shank and knuckle without requirement of a forked end hammer shank with knuckle slot. Best mode spline comprises: an upright rectangular portion and a wide base portion, wherein wide base portion includes an intricate shape. Intricate shape comprises: at least one recess area and at least one protrusion area. The inverse of intricate shape is included on the bottom of the tubular lever interface.

Abstract: The present invention relates to methods and immunonutritional compositions for preventing the impairment of the immune function during anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently preventing or moderating, bone marrow paralysis or neutropenia of a subject undergoing anti-cancer therapy-induced apoptosis or necrosis or other cell damage such that the innate and adaptive immune functions and normal physiology of the bone marrow are preserved, at least in part, which, in turn, lead to (i) a better tolerance and increased efficacy to anti-cancer therapy; (ii) transient augmentation or enhancement of immunocompetence of the immune cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened by anti-cancer therapy.

Abstract: The present invention relates to methods and immunonutritional compositions for preventing the impairment of the immune function during anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently augment or enhance the immunocompetence of an immune cell and the immunogenecity of a tumor cell of a subject undergoing anti-cancer therapy-induced apoptosis and tumor-cell-enhanced immunogenicity such that the innate and adaptive immune functions and normal physiology of the immune cell are preserved, which, in turn, lead to (i) a better tolerance and increased efficacy to anti-cancer therapy; (ii) transient augmentation or enhancement of immunocompetence of the immune cell and immunogenecity of the tumor cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened by anti-cancer therapy.

Abstract: The present invention relates to methods and immunonutritional compositions for preventing or mitigating paralysis of the bone marrow, caused by a tumor or neoplasm, between cycles of and after anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently preventing or moderating, bone marrow paralysis or neutropenia of a subject tumor-induced apoptosis or necrosis or other cell damage such that the innate and adaptive immune functions and normal physiology of the bone marrow are preserved, at least in part, which, in turn, lead to (i) a better tolerance and increased efficacy to treatment; (ii) transient augmentation or enhancement of immunocompetence of the immune cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened due to paralysis of the bone marrow, caused by a tumor or neoplasm.

Abstract: The invention relates to an isolated polynucleotide from coryneform bacteria, comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequences of SEQ ID NO. 2 or SEQ ID NO. 4, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequences of SEQ ID NO. 2 or SEQ ID NO.

Abstract: The present invention relates to compositions and methods for preventing and treating a condition in a mammalian subject that include at least one inhibitor of double stranded RNA dependent protein kinase (PKR-I) prior to or concurrently with the treatment, wherein the treatment results to an inhibition of activation of dsRNA-dependent protein kinase. The compositions and methods of the present invention further include at least one potentiator that further enhances the inhibition of phosphorylation by PKR-I.

Abstract: The invention is directed to DNA sequences from coryneform bacteria, particularly Corynebacterium glutamicum, which encode a protein having transaldolase enzymatic activity. The invention also encompasses processes for the fermentative production of L-amino acids using bacteria in which a gene encoding transaldolase is amplified.

Abstract: The invention provides compounds for use in a method of treating oral pharyngeal dysphagia in an individual and related products. One embodiment of the invention comprises administering to an individual an effective amount of a vanilloid receptor 1 (VR-1) agonist or high-affinity partial agonist to promote a swallow reflex.

Abstract: A universal grand piano piano action that has adjustable connections between the repetition base, heel, and rest cushion bracket of the piano action to provide a piano action that can be adjusted to fit any grand piano. Other components of the grand piano piano action, such as the jack and flanges, may require specific design and manufacture for each brand of grand piano. Universal grand piano piano action also allows true simultaneous half stroke keyboard design for both the white and sharp keys of a piano and includes the methods for installing simultaneous half stroke keyboard design into a grand piano.

Abstract: A hammer shank and a separate shank butt component for a grand piano hammer assembly with increased rigidity, reduced inertia, and the collateral benefits of increased efficiency of manufacture and maintenance. Hammer shank comprises a long cylindrical member that is connected at one end to a traditional grand piano hammer and at the other end to a novel shank butt. Shank butt comprises: a hammer shank hole, a knuckle slot, a set of two flange attachment holes, and a void area. A traditional grand piano knuckle is attached to the knuckle slot. The shank butt is connected to the repetition flange of the piano. The invention provides the capability for a piano to be played with less touch weight on the keys and therefore provides a more responsive piano keyboard. The invention also allows for full “retrofitability” of hammer assembly into all existing grand piano brands. Embodiments include a composite shank butt that is a molded article and a composite hammer shank that is an extruded or molded article.

Abstract: Composite or plastic molded articles used in a grand piano action. A piano action actuates in response to depression on a piano key to swing a hammer into a piano string. The articles are assembled to form a piano action with significantly less dynamic mass which is much more responsive to the touch. In addition, the new action provides the valuable collateral benefits of increased efficiency of manufacture and maintenance. The invention also provides the capability to achieve true half stroke design in both the sharp and white keys. Additionally, the application discloses a universal composite grand piano action that is capable of being installed into any brand of grand piano.

Abstract: Composite or plastic molded articles used in a grand piano piano action. The articles make up a piano action with less dynamic mass which is, thus, more responsive to the piano player. In addition, the new action provides the extremely valuable collateral benefits of increased efficiency of manufacture and maintenance. Low inertia grand piano piano action comprises a repetition base with one or more of the following: an angled main beam, an angled balancier support beam, an integrated jack button stop, and a means to optionally connect a rest cushion assembly. Low inertia grand piano piano action may also comprise a heel with extremely low mass.

Abstract: A hammer assembly for a grand piano comprising: a hammer, a hammer shank, a tubular lever interface, and a moveable knuckle. A grand piano tubular lever interface comprises: a deep socket; a set of two hinge pin attachment holes; a void area; and a moveable knuckle visual location system. A moveable knuckle comprises: a spline; a resilient core; a synthetic buckskin wear surface, and a moveable knuckle visual location system. Novel hammer assembly allows for a direct lever relationship between hammer shank and knuckle without requirement of a forked end hammer shank with knuckle slot. Best mode spline comprises: an upright rectangular portion and a wide base portion, wherein wide base portion includes an intricate shape. Intricate shape comprises: at least one recess area and at least one protrusion area. The inverse of intricate shape is included on the bottom of the tubular lever interface.