Patents by Inventor Kevin A. Gray

Kevin A. Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220282002
    Abstract: This invention relates to the isolation and purification of nutritional supplements and prebiotics, such as xylo-oligosaccharides, and specifically the removal of color bodies, said xylo-oligosaccharides sourced from from ligno-cellulosic feedstocks such as sugar cane and sugar cane bagasse. Removal of color bodies provides greater purity in certain xylo-oligosaccharides as described. This process can also be applied to non-sugar cane feedstocks such as agricultural residues (wheat straw, corn stover, rice straw, etc.), purpose grown crops including but not limited to sugar cane, sorghum, Miscanthus, and woody biomass such as poplar.
    Type: Application
    Filed: March 2, 2022
    Publication date: September 8, 2022
    Applicant: Prenexus Health, Inc.
    Inventor: Kevin A. Gray
  • Publication number: 20220233559
    Abstract: This disclosure relates to the co-production and co-delivery of a pre- and postbiotic and antioxidant that are chemically linked and thus can be delivered as a single product instead of a blend of individual molecules. This xylooligosaccharide (XOS) product is used as a nutritional supplement and/or food ingredient that improves digestive health and overall wellness.
    Type: Application
    Filed: January 27, 2022
    Publication date: July 28, 2022
    Applicant: Prenexus Health, Inc.
    Inventor: Kevin A. Gray
  • Patent number: 10793844
    Abstract: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: October 6, 2020
    Assignee: BASF Enzymes LLC
    Inventors: Kevin A. Gray, Nahla M. Aboushadi, James B. Garrett
  • Publication number: 20180334659
    Abstract: The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal ?-1,4-xylosidic linkages or endo-?-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: December 4, 2017
    Publication date: November 22, 2018
    Inventors: Kevin A. Gray, Reinhard Dirmeier
  • Publication number: 20180334660
    Abstract: The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition, methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at acidic, neutral and alkaline pH and increased temperature.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 22, 2018
    Inventors: Walter CALLEN, Toby RICHARDSON, Gerhard FREY, Jay M. SHORT, Eric J. MATHUR, Kevin A. Gray, Janne S. KEROVUO, Malgorzata SLUPSKA
  • Patent number: 10100293
    Abstract: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: October 16, 2018
    Assignee: BASF Enzymes LLC
    Inventors: Kevin A. Gray, Nahla M. Aboushadi, James B. Garrett
  • Patent number: 10047350
    Abstract: The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at acidic, neutral and alkaline pH and increased temperature.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: August 14, 2018
    Assignee: BASF Enzymes LLC
    Inventors: Walter Callen, Toby Richardson, Gerhard Frey, Jay M. Short, Eric J. Mathur, Kevin A. Gray, Janne S. Kerovuo, Malgorzata Slupska
  • Patent number: 9453211
    Abstract: The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: September 27, 2016
    Assignee: BASF Enzymes LLC
    Inventors: Jay M. Short, Toby Richardson, Dan E. Robertson, Kevin A. Gray
  • Publication number: 20160108386
    Abstract: The invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, ?-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts. The invention also provides compositions or products of manufacture comprising mixtures of enzymes comprising at least one enzyme of this invention.
    Type: Application
    Filed: October 23, 2015
    Publication date: April 21, 2016
    Inventors: Kevin A. Gray, Lishan Zhao, Michelle H. Cayouette
  • Patent number: 9249400
    Abstract: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: February 2, 2016
    Assignee: BASF Enzymes LLC
    Inventors: Kevin A. Gray, Nahla M. Aboushadi, James B. Garrett
  • Patent number: 9175275
    Abstract: The invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, ?-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts. The invention also provides compositions or products of manufacture comprising mixtures of enzymes comprising at least one enzyme of this invention.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: November 3, 2015
    Assignee: BP Corporation North America Inc.
    Inventors: Kevin A. Gray, Lishan Zhao, Michelle H. Cayouette
  • Patent number: 9127263
    Abstract: The invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, ?-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts. The invention also provides compositions or products of manufacture comprising mixtures of enzymes comprising at least one enzyme of this invention.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: September 8, 2015
    Assignee: BP Corporation North America Inc.
    Inventors: Kevin A. Gray, Lishan Zhao, Michelle H. Cayouette
  • Publication number: 20140298499
    Abstract: The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal ?-1,4-xylosidic linkages or endo-?-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: December 16, 2013
    Publication date: October 2, 2014
    Applicant: BP Corporation North America Inc.
    Inventors: Kevin A. Gray, Reinhard Dirmeier
  • Patent number: 8486680
    Abstract: The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal ?-1,4-xylosidic linkages or endo-?-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: July 16, 2013
    Assignees: BP Corporation North America Inc., Verenium Corporation
    Inventors: Kevin A. Gray, Reinhard Dirmeier
  • Publication number: 20130115675
    Abstract: The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: April 9, 2012
    Publication date: May 9, 2013
    Applicant: VERENIUM CORPORATION
    Inventors: Jay M. Short, Toby Richardson, Dan E. Robertson, Kevin A. Gray
  • Patent number: 8334118
    Abstract: The invention relates to alpha amylases and to polynucleotides and polypeptides encoding the alpha amylases. In addition, methods of using the alpha amylases are also provided. The alpha amylases have increased activity and stability at acidic, neutral and alkaline pH and at increased temperatures.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: December 18, 2012
    Assignee: Verenium Corporation
    Inventors: Walter Callen, Toby Richardson, Gerhard Frey, Jay M. Short, Eric J. Mathur, Kevin A. Gray, Janne S. Kerovuo, Malgorzata Slupska
  • Patent number: 8222035
    Abstract: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: July 17, 2012
    Assignee: Verenium Corporation
    Inventors: Walter Callen, Toby Richardson, Gerhard Frey, Kevin A. Gray, Janne S. Kerovuo, Malgorzata Slupska, Nelson R. Barton, Eileen O'Donoghue, Carl Miller
  • Publication number: 20120040412
    Abstract: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: VERENIUM CORPORATION
    Inventors: Kevin A. Gray, Nahla Aboushadi, James B. Garrett
  • Patent number: 8101393
    Abstract: The invention provides polypeptides having any cellulolytic activity, e.g., a cellulase activity, a endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a ?-xylosidase, an arabinofuranosidase, and/or an oligomerase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, ?-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides having an oligomerase activity, e.g., enzymes that convert recalcitrant soluble oligomers to fermentable sugars in the saccharification of biomass.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: January 24, 2012
    Assignee: BP Corporation North America Inc.
    Inventors: Kevin A. Gray, Lishan Zhao, Michelle H. Cayouette
  • Patent number: RE46733
    Abstract: The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal ?-1,4-xylosidic linkages or endo-?-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: February 27, 2018
    Assignee: BP Corporation North America Inc.
    Inventors: Kevin A. Gray, Richard Dirmeier