Patents by Inventor Kevin A. Jarrell

Kevin A. Jarrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9970036
    Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 15, 2018
    Assignee: MODULAR GENETICS, INC.
    Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
  • Patent number: 9493800
    Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: November 15, 2016
    Assignee: MODULAR GENETICS, INC.
    Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
  • Publication number: 20160076065
    Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.
    Type: Application
    Filed: March 14, 2014
    Publication date: March 17, 2016
    Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
  • Publication number: 20130071885
    Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
    Type: Application
    Filed: July 19, 2011
    Publication date: March 21, 2013
    Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
  • Patent number: 7981685
    Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: July 19, 2011
    Assignee: Modular Genetics, Inc.
    Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
  • Publication number: 20110059487
    Abstract: The present invention provides, among other things, engineered microorganisms and methods that allow efficient conversion of soy carbohydrates to industrial chemicals by fermentation. In some embodiments, the invention provides microbial cells engineered to have increased efficiency in utilizing a soy carbon source (e.g., soy molasses, soy meal, and/or soy hulls) as compared to a parent cell. In some embodiments, microbial cells are engineered to have altered (e.g., increased) expression or activity of one or more carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, microbial cells are engineered to have altered localization of carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, engineered microbial cells provided herein are used to produce industrial chemicals (e.g., surfactin) using soy components as primary or sole carbon sources.
    Type: Application
    Filed: June 24, 2010
    Publication date: March 10, 2011
    Applicant: Modular Genetics, Inc.
    Inventors: Kevin A. Jarrell, Gabriel Reznik, Michelle A. Pynn
  • Publication number: 20110034557
    Abstract: Antimicrobial compositions and methods of using the compositions are described herein. The compositions include an antibacterial acyl amino acid. In some embodiments, the acyl amino acid is a fatty acylated glutamate. The methods herein include methods of using acyl amino acids for treating and preventing bacterial infections.
    Type: Application
    Filed: February 19, 2010
    Publication date: February 10, 2011
    Applicant: MODULAR GENETICS, INC.
    Inventors: Kevin A. Jarrell, Gabriel Reznik
  • Publication number: 20110030102
    Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
    Type: Application
    Filed: April 16, 2008
    Publication date: February 3, 2011
    Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
  • Publication number: 20110030103
    Abstract: Novel lipopeptides, and engineered polypeptides useful in synthesizing lipopeptides are provided. Also provided are methods of making lipopeptides using engineered polypeptides, and methods of using lipopeptides, e.g., as insecticidal and/or antimicrobial agents.
    Type: Application
    Filed: April 16, 2008
    Publication date: February 3, 2011
    Inventors: Gabriel Reznik, Kevin A. Jarrell, Prashanth Vishwanath
  • Publication number: 20100093060
    Abstract: The present invention provides novel methods of growing of microorganisms in cell culture media comprising cellulosic material as a carbon source. The present invention further provides novel cell culture media cellulosic material as a carbon source. In certain embodiments, inventive cell culture media substantially lack a carbon source other than cellulosic material (e.g., the media substantially lack glucose and glycerol). In certain embodiments, inventive cell culture media comprise cellulosic material as the sole carbon source.
    Type: Application
    Filed: September 23, 2009
    Publication date: April 15, 2010
    Inventors: Kevin A. Jarrell, Gabriel Reznik, Michelle A. Pynn, Joy D. Sitnik
  • Publication number: 20090269832
    Abstract: The present invention provides novel methods of growing of microorganisms in cell culture media comprising crude glycerol as a carbon source. The present invention further provides novel cell culture media comprising crude glycerol as a carbon source. In certain embodiments, inventive cell culture media substantially lack refined glycerol. In certain embodiments, inventive cell culture media comprise crude glycerol as the sole carbon source.
    Type: Application
    Filed: November 4, 2008
    Publication date: October 29, 2009
    Applicant: Modular Genetics, Inc.
    Inventors: Kevin A. Jarrell, Gabriel Reznik
  • Patent number: 7579146
    Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: August 25, 2009
    Assignee: Trustees of Boston University
    Inventors: Kevin A. Jarrell, Vincent W. Coljee, William Donahue, Svetlana Mikheeva
  • Publication number: 20090176281
    Abstract: The present invention provides improved techniques and reagents for producing nucleic acid molecules. In certain preferred embodiments, the nucleic acid molecules are modular vectors. In certain preferred embodiments, the nucleic acid molecules are produced in polymerase chain reactions employing terminator primer residues.
    Type: Application
    Filed: October 14, 2008
    Publication date: July 9, 2009
    Inventors: Kevin A. Jarrell, William F. Donahue, Brian M. Turczyk
  • Patent number: 7439021
    Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: October 21, 2008
    Assignee: Trustees of Boston University
    Inventors: Kevin A. Jarrell, Vincent W. Coljee, William Donahue, Svetlana Mikheeva
  • Patent number: 7435562
    Abstract: The present invention provides improved techniques and reagents for producing nucleic acid molecules. In certain preferred embodiments, the nucleic acid molecules are modular vectors. In certain preferred embodiments, the nucleic acid molecules are produced in polymerase chain reactions employing terminator primer residues.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: October 14, 2008
    Assignees: Modular Genetics, Inc., The Trustees of Boston University
    Inventors: Kevin A. Jarrell, William F. Donahue, Brian M. Turczyk
  • Publication number: 20040161752
    Abstract: The present invention provides improved techniques and reagents for producing nucleic acid molecules. In certain preferred embodiments, the nucleic acid molecules are modular vectors. In certain preferred embodiments, the nucleic acid molecules are produced in polymerase chain reactions employing terminator primer residues.
    Type: Application
    Filed: March 5, 2003
    Publication date: August 19, 2004
    Inventors: Kevin A. Jarrell, William F. Donahue, Brian M. Turczyk
  • Publication number: 20030017552
    Abstract: The present invention encompasses the recognition that vectors utilized in molecular biology need not be provided as single intact molecules but rather can be assembled from fragments containing functional elements, or portions thereof. In certain preferred embodiments of the invention, vector fragments are linked together simultaneously with the linkage of vector and insert sequences to one another.
    Type: Application
    Filed: July 20, 2001
    Publication date: January 23, 2003
    Inventors: Kevin A. Jarrell, William Donahue
  • Patent number: 6358712
    Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: March 19, 2002
    Assignee: Trustee of Boston University
    Inventors: Kevin A. Jarrell, Vincent W. Coljee, William Donahue, Svetlana Mikheeva
  • Patent number: 6150141
    Abstract: The present invention makes available methods and reagents for novel manipulation of nucleic acids. As described herein, the present invention makes use of the ability of intronic sequences, such as derived from group I, group II, or nuclear pre-mRNA introns, to mediate specific cleavage and ligation of discontinuous nucleic acid molecules. For example, novel genes and gene products can be generated by admixing nucleic acid constructs which comprise exon nucleic acid sequences flanked by intron sequences that can direct trans-splicing of the exon sequences to each other. The flanking intronic sequences can, by intermolecular complementation, form a reactive complex which promotes the transesterification reactions necessary to cause the ligation of discontinuous nucleic acid sequences to one another, and thereby generate a recombinant gene comprising the ligated exons.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: November 21, 2000
    Assignee: Trustees of Boston University
    Inventor: Kevin A. Jarrell
  • Patent number: 5780272
    Abstract: The present invention makes available methods and reagents for novel manipulation of nucleic acids. As described herein, the present invention makes use of the ability of intronic sequences, such as derived from group I, group II, or nuclear pre-mRNA introns, to mediate specific cleavage and ligation of discontinuous nucleic acid molecules. For example, novel genes and gene products can be generated by admixing nucleic acid constructs which comprise exon nucleic acid sequences flanked by intron sequences that can direct trans-splicing of the exon sequences to each other. The flanking intronic sequences can, by intermolecular complementation, form a reactive complex which promotes the transesterification reactions necessary to cause the ligation of discontinuous nucleic acid sequences to one another, and thereby generate a recombinant gene comprising the ligated exons.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 14, 1998
    Assignee: President and Fellows of Harvard College
    Inventor: Kevin A. Jarrell