Abstract: A post cap is provided that is formed of a material having increased durability from the prior art post cap formed of plastics. The material includes some plastic components but also includes other compounds that provide the increased weight and durability to the post cap. The material includes a plastic, a solidifying agent, an accelerating agent, and a filler, optionally in conjunction with other ingredients, such as a color and one or more fillers. The material forming the post cap is formed in a mold in a suitable molding process, such as a casting process.

Abstract: The instant invention provides for compounds of formula A that inhibit PDK1 activity: The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting PDK1 activity by administering the compound to a patient in need of treatment of cancer.

Abstract: The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.

Abstract: The instant invention provides for compounds that inhibit PDK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting PDK1 activity by administering the compound to a patient in need of treatment of cancer.

Abstract: The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.

Abstract: A system (1) has a server (2) linked with PC clients (5), in turn connected to test equipment (10). A design-of-experiment (DOE) engine (20) generates a series of run objects (21), each defining a variation of an equipment run. The inputs to the DOE engine (20) are a selected procedure object (25) and experiment variations. The engine (20) automatically determines all task objects (26), resource objects (27), and parameter configuration objects (28) linked with the selected procedure object (25). The variations may be variations in the hierarchical links and/or different values for the parameter configurations (28). There is a run object (21) associated with each variation permutation.

Abstract: A scientific experiment control system includes a main controller for high-level control, an experimental manager for lower-level control of scientific experiments, and a roll-up engine for automatically propagating modifications (or “changes”) within the system to ensure consistency across the system and instruments which are linked to it in an automatic and dynamic manner. When any of experiment control objects automatically detects a change event as defined by any of the metrics inherited from the metric objects it transmits a notification to an interface. The latter automatically instantiates a change event object, which is managed in a queue by an input interface of the roll-up engine. The roll-up engine automatically interrogates the network of objects contained in the program object to determine the identity of every object in the hierarchy down to the notifying object which is involved in performance of the current experiment run.

Abstract: A system (1) has a server (2) linked with PC clients (5), in turn connected to test equipment (10). A design-of-experiment (DOE) engine (20) generates a series of run objects (21), each defining a variation of an equipment run. The inputs to the DOE engine (20) are a selected procedure object (25) and experiment variations. The engine (20) automatically determines all task objects (26), resource objects (27), and parameter configuration objects (28) linked with the selected procedure object (25). The variations may be variations in the hierarchical links and/or different values for the parameter configurations (28). There is a run object (21) associated with each variation permutation.