Abstract: A heater includes a sintered assembly and a functional element disposed on one of opposing surfaces of the sintered assembly. The heater is manufactured by a method that includes hot pressing a ceramic powder and a plurality of first slugs and forming the sintered assembly including a ceramic substrate and the plurality of first slugs embedded therein, forming the functional element on the one opposing surface of the sintered assembly such that the functional element is connected to the plurality of first slugs, and forming a monolithic substrate in which the functional element and the plurality of first slugs are embedded.

Abstract: Methods and systems for inserting targeted advertisements into video content. One or more embodiments analyze video content to identify media insertion locations on digital object surfaces for inserting advertisements. Additionally, one or more embodiments select advertisements to insert into the video content at the media insertion locations based on the media insertion locations, a viewer, or a viewing device of the viewer. One or more embodiments also digitally insert the advertisements into the video content by placing the selected advertisements at the media insertion locations corresponding to the digital object surfaces. One or more embodiments then provide the video content with the targeted advertisements to the viewing device of the viewer.

Abstract: A method of constructing a heater includes the steps of forming a sintered assembly including a ceramic substrate and a plurality of first slugs embedded therein, forming a functional element on one of opposing surfaces of the sintered assembly such that the functional element is connected to the plurality of first slugs, and forming a monolithic substrate in which the functional element and the plurality of first slugs are embedded.

Abstract: A flow control valve sub including a tubular valve sub housing having a sub central passage and a valve cavity formed in a sidewall of the sub housing. At least one piston aperture and at least one constant area pilot aperture communicate between the valve cavity and the sub central passage, while a piston is positioned in the piston aperture with the piston moving to at least partially cover and uncover the flow port in order to create a variable flow path between the valve cavity and the sub central passage. A beam spring is supported at a location within the cavity on each side of the piston and biases the piston toward a less flow restrictive position relative to the flow port and a valve cover is positioned to substantially close the valve cavity.

Abstract: A method and system for distributing electronic ticket status information over a network to a remote subscriber portable computing device for a live event includes providing an electronic ticket manager application to a subscriber for installation on the remote subscriber portable computing device. Ticket data for the live event is received over the Internet with a transmission server which has a microprocessor and a memory that stores a remote subscriber's preferences for ticket information format and destination address. The microprocessor filters the ticket data based on past live events and other subscribers who have attended past live events with the subscriber in a group seating arrangement. The microprocessor generates an alert that activates the portable computing device to display a message that suggests the subscriber may attend the live event and invite other subscribers to sit with the subscriber at the event.

Abstract: The present invention relates to a rapid, high-fidelity process to support synthesis of genes for in vitro transcription of modified messenger RNA. In this process, sequence errors resulting from amplification with oligonucleotides comprising inherent errors are significantly reduced.

Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HC dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: Methods, systems, and non-transitory computer readable storage media are disclosed for dynamically generating discounted product digital notifications based on remaining product shelf life. For example, in one or more embodiments, the disclosed system determines an expiration date or a target product available for purchase from a merchant. Additionally, in one or more embodiments, the disclosed system utilizes a machine-learning model to dynamically generate discount prices for the target product over time based on the expiration date. In one or more embodiments, the disclosed system identifies a client device of a customer and provides a discount price for the target product for a given time window to the client device of the customer.

Abstract: The present invention provides a method of providing pain relief in a human subject in need thereof comprising administering (R)-dihydroetorphine to said subject, wherein said (R)-dihydroetorphine is administered in a dose of at least 0.01 ?g/kg, preferably at least 0.05 ?g/kg, and the level of respiratory depression in said subject is 65 or less % relative to the baseline level pre-administration of (R)-dihydroetorphine.

Abstract: The present invention provides a method of providing pain relief in a human subject in need thereof comprising administering (R)-dihydroetorphine to said subject, wherein said (R)-dihydroetorphine is administered in a dose of at least 0.01 ?g/kg, preferably at least 0.05 ?g/kg, and the level of respiratory depression in said subject is 65 or less % relative to the baseline level pre-administration of (R)-dihydroetorphine.

Abstract: Gas generator for a safety system, comprising: at least one pyrotechnic substance arranged to produce gases; a first part; a second part; a third part; and a fourth part separate from the previous parts, the first part and the second part being friction-welded to the third part. The gas generator is characterised in that the fourth part comprises: a first interface for positioning with the first part, and a second interface for positioning with the second part, such as to temporarily block at least one degree of freedom between the first and second parts in order to allow the first and second parts to be simultaneously friction-welded to the third part.

Abstract: The present disclosure provides a sensor cleaning system that cleans one or more sensors of an autonomous vehicle. Each sensor can have one or more corresponding sensor cleaning units that are configured to clean such sensor using a fluid (e.g., a gas or a liquid). Thus, the sensor cleaning system can include both a gas cleaning system and a liquid cleaning system. According to one aspect, the sensor cleaning system can provide individualized cleaning of the autonomous vehicle sensors. According to another aspect, a liquid cleaning system can be pressurized or otherwise powered by the gas cleaning system or other gas system.

Abstract: A heater assembly and method of controlling the heater assembly is provided. The heater assembly includes a resistive heater and a substrate, and the resistive heater comprises a plurality of heating zones disposed along a perimeter of the substrate. Each of the plurality of heating zones are independently controllable such that azimuthal temperature control of the heater assembly is provided. The plurality of resistive heating elements may be connected in series and have a common ground electrical lead. In the alternative, the plurality of resistive heating elements may each have a ground electrical lead and be isolated from each other.

Abstract: An automated external defibrillator soft carrying case includes a first compartment and a second compartment. The first compartment is connected to the second compartment by a hinge mechanism. The first compartment is also detachably connected to the second compartment. A first compartment ceiling is connected to the first compartment by a second hinge mechanism. The first compartment ceiling includes a transparent window.

Abstract: Methods, systems, and computer readable storage media for improving predictive analytics for performance of digital design assets. In particular, one or more embodiments train a machine-learning model based on previously used digital design assets. One or more embodiments use the machine-learning model to analyze attributes of a user-generated digital design asset to generate an asset score that predicts the performance of the user-generated digital design asset for a target audience segment. One or more embodiments also use the machine-learning model to generate attribute scores for the attributes, and then generate the asset score based on the attribute scores. Additionally, one or more embodiments then provide the asset score to a user (e.g., a content creator) within an asset creation application to allow the user to improve the digital design asset for use in one or more digital content campaigns directed to the target audience segment.

Abstract: A method of constructing a heater includes providing a substrate, forming at least one trench into the substrate, depositing a functional material onto the substrate and into the at least one trench to form a functional element, and providing an electrical termination in contact with the functional element.

Abstract: Offline consumer behavior and interactions are observed using beacons positioned at venues where consumers spend time and interact with each other. The beacons communicate with mobile computing devices that are carried by the observed consumers. The observed consumer behavior provides actionable insights into how consumers influence each other. For example, the people that a particular consumer spends time with form a “circle of influence” associated with that consumer. If the consumer makes a purchase, members of the circle of influence are observed to understand the degree to which they were influenced by the purchase, if at all. Metrics that quantify a consumer's influence over other consumers allow marketers to more effectively target both the influencing and influenced consumers. Also, if relatively little information is known about a particular consumer, that consumer's digital marketing profile can be supplemented using information known about the consumers with whom he/she often spends time.

Abstract: Methods and systems for inserting targeted advertisements into video content. One or more embodiments analyze video content to identify media insertion locations on digital object surfaces for inserting advertisements. Additionally, one or more embodiments select advertisements to insert into the video content at the media insertion locations based on the media insertion locations, a viewer, or a viewing device of the viewer. One or more embodiments also digitally insert the advertisements into the video content by placing the selected advertisements at the media insertion locations corresponding to the digital object surfaces. One or more embodiments then provide the video content with the targeted advertisements to the viewing device of the viewer.

Abstract: Computer-implemented systems and methods disclosed herein disclose features for determining the frequency of exposure to real-world products embedded with Internet-Of-Things (IoT) hardware and determining a comprehensive targeting profile identifying the interests of users based on their exposure to real-world products. A computing device carried by a user wirelessly receives product exposure data from a nearby IoT-enabled device upon entering within a certain proximity of the IoT-enabled device. The computing device further compiles the product exposure data with previous product exposure data for IoT-enabled devices to which the computing device was previously exposed. Based on the compiled product exposure data, a server device determines a frequency of exposure to a product corresponding to the IoT-enabled device over a period of time.

Abstract: The present disclosure provides a sensor cleaning system that cleans one or more sensors of an autonomous vehicle. Each sensor can have one or more corresponding sensor cleaning units that are configured to clean such sensor using a fluid (e.g., a gas or a liquid). Thus, the sensor cleaning system can include both a gas cleaning system and a liquid cleaning system. According to one aspect, the sensor cleaning system can provide individualized cleaning of the autonomous vehicle sensors. According to another aspect, a liquid cleaning system can be pressurized or otherwise powered by the gas cleaning system or other gas system.