Abstract: The disclosure relates to methods and compositions comprising atropine and a polymer in a gel formulation for decreasing saliva production and treating sialorrhea.

Abstract: A syringe and needle hub for a syringe has distal patient-facing side having a surface for contact with the subject’s skin during injection. The contact surface is formed by a distal face of a post supporting a cannula and an outer collar surrounding the post. The axial distance between the distal face of the post and the distal face of the collar provided a contact surface with a radius of curvature to control the desired injection. The syringe barrel can have finger flanges extending outwardly where the flanges have a tactile member such as a dimple projecting from a proximal face of the flange and recess in a distal face of the flange.

Abstract: A method of processing signal paths includes receiving an estimated location for a GNSS receiver in an environment. The method also includes generating a plurality of candidate positions about the estimated location where each candidate position corresponds to a possible actual location of the GNSS receiver. The method further includes, for each available satellite at each candidate position, modeling a plurality of candidate signal paths by ray-launching a raster map of geographical data. Here, the plurality of candidate signal paths includes one or more reflected signal paths. At each candidate position, the method also includes comparing, the plurality of candidate signal paths modeled for each available satellite at the respective candidate position to measured GNSS signal data from the GNSS receiver and generating a likelihood that the respective candidate position includes the actual location of the GNSS receiver based on the comparison.

Abstract: A syringe and needle hub for a syringe has distal patient-facing side having a surface for contact with the subject's skin during injection. The contact surface is formed by a distal face of a post supporting a cannula and an outer collar surrounding the post. The axial distance between the distal face of the post and the distal face of the collar provided a contact surface with a radius of curvature to control the desired injection. The syringe barrel can have finger flanges extending outwardly where the flanges have a tactile member such as a dimple projecting from a proximal face of the flange and recess in a distal face of the flange.

Abstract: Various examples according to the present disclosure provide a fermentation method. The fermentation method includes producing at least about 10 g/L of a bioproduct and one or more heterologous polypeptides by fermenting a medium using an engineered microorganism. About 2 wt % to about 100 wt % of the one or more heterologous polypeptides are encapsulated intercellularly in the engineered microorganism. The method further includes isolating the engineered microorganism including the encapsulated one or more heterologous polypeptides. About 50 wt % to about 100 wt % of the one or more heterologous polypeptides retain functionality following isolation of the engineered microorganism.

Abstract: A method of localization using bearing from environmental features includes receiving an estimated location of a global navigation satellite system (GNSS) receiver associated with a user and a corresponding bearing for the GNSS receiver. The method also includes identifying one or more environmental features about the estimated location of the GNSS receiver. The method further includes determining whether an orientation of a respective environmental feature of the one or more environmental features correlates to the corresponding bearing for the GNSS receiver. When the orientation of the respective environmental feature correlates to the corresponding bearing for the GNSS receiver, the method includes generating an updated bearing for the GNSS receiver or locational system that matches the orientation of the respective environmental feature.

Abstract: A method of localization using bearing from environmental features includes receiving an estimated location of a global navigation satellite system (GNSS) receiver associated with a user and a corresponding bearing for the GNSS receiver. The method also includes identifying one or more environmental features about the estimated location of the GNSS receiver. The method further includes determining whether an orientation of a respective environmental feature of the one or more environmental features correlates to the corresponding bearing for the GNSS receiver. When the orientation of the respective environmental feature correlates to the corresponding bearing for the GNSS receiver, the method includes generating an updated bearing for the GNSS receiver or locational system that matches the orientation of the respective environmental feature.

Abstract: A method of processing signal paths includes receiving an estimated location for a GNSS receiver in an environment. The method also includes generating a plurality of candidate positions about the estimated location where each candidate position corresponds to a possible actual location of the GNSS receiver. The method further includes, for each available satellite at each candidate position, modeling a plurality of candidate signal paths by ray-launching a raster map of geographical data. Here, the plurality of candidate signal paths includes one or more reflected signal paths. At each candidate position, the method also includes comparing, the plurality of candidate signal paths modeled for each available satellite at the respective candidate position to measured GNSS signal data from the GNSS receiver and generating a likelihood that the respective candidate position includes the actual location of the GNSS receiver based on the comparison.

Abstract: A syringe needle shield (10) and a method of using the syringe needle shield (10) that is configured to enclose a needle el (4) of a syringe (2), the syringe needle shield (10) comprising a proximal end (20) providing access to an inner cavity (50), a distal end (22) including a flange (30), and an outer surface (24) including a plurality of ribs (40) disposed adjacent to the flange (30), each of the plurality of ribs (40) including a substantially flat surface (42) and a concave surface (44), wherein the substantially flat surface (42) is adjacent to the concave surface (44).

Abstract: A process of stimulating hydrocarbon recovery is described and claimed. This process includes introducing a gas, a liquified gas or a vaporized liquified gas, into an underground formation containing hydrocarbons such as crude oil and gas, permitting said gas to be absorbed by said hydrocarbons, and withdrawing said hydrocarbons containing the gas therein, wherein a pill of Hydrocarbon Recovery Fluid comprising surface functionalized nanoparticles is inserted into the underground formation containing hydrocarbons before, during or after the introduction of the gas, liquified gas or a vaporized liquified gas.

Abstract: A syringe and needle hub for a syringe has distal patient-facing side having a surface for contact with the subject's skin during injection. The contact surface is formed by a distal face of a post supporting a cannula and an outer collar surrounding the post. The axial distance between the distal face of the post and the distal face of the collar provided a contact surface with a radius of curvature to control the desired injection. The syringe barrel can have finger flanges extending outwardly where the flanges have a tactile member such as a dimple projecting from a proximal face of the flange and recess in a distal face of the flange.

Abstract: A process of stimulating hydrocarbon recovery is described and claimed. This process includes introducing a gas, a liquified gas or a vaporized liquified gas, into an underground formation containing hydrocarbons such as crude oil and gas, permitting said gas to be absorbed by said hydrocarbons, and withdrawing said hydrocarbons containing the gas therein, wherein a pill of Hydrocarbon Recovery Fluid comprising surface functionalized nanoparticles is inserted into the underground formation containing hydrocarbons before, during or after the introduction of the gas, liquified gas or a vaporized liquified gas.

Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.

Abstract: A method of enabling in-store pick up of customized goods ordered online is described. The method may include receiving an online purchase order at a website including a customized product description and a brick-and-mortar store identifier. The method may also include sending the purchase order to a computing device associated with the brick-and-mortar store identifier and receiving an in-stock confirmation at the computing device. The method may also include receiving an order completed confirmation at the computing device and sending a customer correspondence that includes a pick-up time designating when a customer may pick up the customized product at the brick-and-mortar store. The method may also include receiving an in-store pick up confirmation at the computing device.

Abstract: This invention describes genes, metabolic pathways, microbial strains and methods to produce methylbutanol and other compounds of interest from renewable feedstocks.

Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.

Abstract: This invention describes genes, metabolic pathways, microbial strains and methods to produce methylbutanol and other compounds of interest from renewable feedstocks.

Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.

Abstract: Genes and strains of recombinant microorganisms are provided that are engineered to produce fatty alcohols and fatty alcohol derivatives. The organisms can include one, two, three or more transgenes that direct the biosynthesis of one or more fatty alcohols or derivatives. Methods of producing fatty alcohols using transgenic microorganisms are also provided.