Abstract: A sterile drape assembly for draping equipment to create a sterile barrier around the equipment may comprise a hollow elongated drape body and a closure mechanism. The drape body extends between a first end and a second end and has a first drape portion comprising the first end and a second drape portion comprising the second end. The closure mechanism releasably closes, or is configured to releasably close, the first end of the drape body. The sterile drape assembly has a partially inverted state in which the first drape portion is folded back over and covers the second drape portion, and the second drape portion defines a partially enclosed interior volume configured to receive at least a first portion of the equipment.

Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: An apparatus for dosing a fluid flow system with treatment fluid/chemicals is described. The apparatus includes a vessel; an inlet pipe or hose and an outlet pipe for coupling to the system so that fluid from the system may flow into the vessel and return into the system to flush chemicals from within the vessel and into the system. The vessel has a piston within it and the vessel wall defines a cylinder in which the piston moves under pressure of incoming fluid from a first position at which the vessel contains fluid to be dispensed into the system to a second position corresponding to substantially complete emptying of the vessel. The piston has a bypass passage through or around it that opens when the piston substantially reaches the second position so that fluid from the system may flow passed the piston when the piston is at the second position.

Abstract: Apparatus for dispensing a dose of fluid, the apparatus comprising a dispensing vessel with a dispensing outlet, the vessel having a piston and a vessel wall defining a cylinder in which the piston may move under pressure from a first position to a second position, wherein the apparatus has a bypass passage that extends through the first piston and has a valve member that is opened by a valve actuating plunger in the piston that moves within the piston to push the valve open when the valve actuating plunger abuts a shoulder at or near the second position in the vessel; wherein the shoulder at the second position is an annular shoulder and the apparatus is adapted to dispense fluid in a sequence of stages comprising a mixing stage and a dispensing stage.

Abstract: An apparatus for dosing a fluid flow system with treatment fluid/chemicals is described. The apparatus includes a vessel; an inlet pipe or hose and an outlet pipe for coupling to the system so that fluid from the system may flow into the vessel and return into the system to flush chemicals from within the vessel and into the system. The vessel has a piston within it and the vessel wall defines a cylinder in which the piston moves under pressure of incoming fluid from a first position at which the vessel contains fluid to be dispensed into the system to a second position corresponding to substantially complete emptying of the vessel. The piston has a bypass passage through or around it that opens when the piston substantially reaches the second position so that fluid from the system may flow passed the piston when the piston is at the second position.

Abstract: An apparatus for dosing a fluid flow system with a treatment fluid/chemicals is described. The apparatus includes: a vessel; an inlet pipe and an outlet pipe for coupling to the system so that fluid from the system may flow into the vessel and return into the system to flush chemicals from within the vessel into the system. The vessel has a piston within it and the vessel wall defines a cylinder in which the piston moves under pressure of incoming fluid from a first position at which the vessel contains fluid to be dispensed into the system to a second position corresponding to substantially complete emptying of the vessel. The piston has a bypass passage through or around it that opens when the piston substantially reaches the second position so that fluid from the system may flow passed the piston when the piston is at the second position.