Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: System and methods for creating a geospatial network model in a client environment are disclosed. The system residing on a client device receives Geographic Information System (GIS) data for a distribution network, which includes spatial information and non-spatial information (e.g., attributes) relating to features in the distribution network, from a remote GIS database. The system uses the spatial information in the GIS data to construct an undirected graph that is represented by a set of adjacency relationships between the features and utilizes the non-spatial information to traverse the undirected graph in order to construct a directed graph that is represented as a set of directed adjacency relationships between the features. The system stores the data structure corresponding to the directed graph in the form of an array or hashtable in the client device's cache memory for use in performing network analyses such as tracing analysis without accessing the GIS database.

Abstract: System and methods for creating a geospatial network model in a client environment are disclosed. The system residing on a client device receives Geographic Information System (GIS) data for a distribution network, which includes spatial information and non-spatial information (e.g., attributes) relating to features in the distribution network, from a remote GIS database. The system uses the spatial information in the GIS data to construct an undirected graph that is represented by a set of adjacency relationships between the features and utilizes the non-spatial information to traverse the undirected graph in order to construct a directed graph that is represented as a set of directed adjacency relationships between the features. The system stores the data structure corresponding to the directed graph in the form of an array or hashtable in the client device's cache memory for use in performing network analyses such as tracing analysis without accessing the GIS database.

Abstract: A system and methods for optimizing distribution network designs are disclosed. In some embodiments, the disclosed system detects placement of a component in a network design. In response, the disclosed system generates multiple design alternatives incorporating the component in different configurations and/or at different locations. The disclosed system determines in parallel a design goal metric associated with at least one design goal that is to be optimized for each of the design alternatives including the original design. The disclosed system then identifies a preferred network design based on the goal metrics. The goal metric of the preferred distribution network design indicates a higher level of optimization with respect to the at least one design goal compared to other of the design alternatives. By performing the optimization, the disclosed system ensures that the optimal configuration is selected and applied in the design.

Abstract: System and method for validating distribution network configuration changes in a client environment are disclosed. The system residing on a client device detects network configuration changes made by a user. The disclosed system, working with a locally stored model of the network, validates the network configuration changes against one or more validation rules that are also stored locally in the client device. When validating the network configuration changes, the disclosed system can perform a number of network engineering calculations to detect invalid network configuration changes. The disclosed system then provides graphical feedback in real time to inform the user of any invalid network configuration changes.

Abstract: System and method for syncing and merging network changes to a distribution network are disclosed. In some embodiments, network changes made to a network outside of a Geographic Information System (GIS) can be synced to the GIS so that the GIS remains an enterprise's primary repository for network information. In some embodiments, the disclosed system enables comparing and merging of network states using a command-based technique that significantly reduces the number of possible merge conflicts.

Abstract: A system and methods for optimizing distribution network designs are disclosed. In some embodiments, the disclosed system detects placement of a component in a network design. In response, the disclosed system generates multiple design alternatives incorporating the component in different configurations and/or at different locations. The disclosed system determines in parallel a design goal metric associated with at least one design goal that is to be optimized for each of the design alternatives including the original design. The disclosed system then identifies a preferred network design based on the goal metrics. The goal metric of the preferred distribution network design indicates a higher level of optimization with respect to the at least one design goal compared to other of the design alternatives. By performing the optimization, the disclosed system ensures that the optimal configuration is selected and applied in the design.

Abstract: System and method for validating distribution network configuration changes in a client environment are disclosed. The system residing on a client device detects network configuration changes made by a user. The disclosed system, working with a locally stored model of the network, validates the network configuration changes against one or more validation rules that are also stored locally in the client device. When validating the network configuration changes, the disclosed system can perform a number of network engineering calculations to detect invalid network configuration changes. The disclosed system then provides graphical feedback in real time to inform the user of any invalid network configuration changes.

Abstract: System and method for syncing and merging network changes to a distribution network are disclosed. In some embodiments, network changes made to a network outside of a Geographic Information System (GIS) can be synced to the GIS so that the GIS remains an enterprise's primary repository for network information. In some embodiments, the disclosed system enables comparing and merging of network states using a command-based technique that significantly reduces the number of possible merge conflicts.

Abstract: System and methods for creating a geospatial network model in a client environment are disclosed. The system residing on a client device receives Geographic Information System (GIS) data for a distribution network, which includes spatial information and non-spatial information (e.g., attributes) relating to features in the distribution network, from a remote GIS database. The system uses the spatial information in the GIS data to construct an undirected graph that is represented by a set of adjacency relationships between the features and utilizes the non-spatial information to traverse the undirected graph in order to construct a directed graph that is represented as a set of directed adjacency relationships between the features. The system stores the data structure corresponding to the directed graph in the form of an array or hashtable in the client device's cache memory for use in performing network analyses such as tracing analysis without accessing the GIS database.

Abstract: Systems and methods to provide users with a user interface at the point of use that provides customizable, interactive protocols, where a protocol is typically an instruction set, procedure, or methodology.

Abstract: Systems and methods to provide users with a user interface at the point of use that provides customizable, interactive protocols, where a protocol is typically an instruction set, procedure, or methodology.

Abstract: A network and method to establish a real-time location based service for client mobile device users. Asynchronous data connections are established between client mobile devices and a data server over wireless networks. Synchronous data connections are established between the client devices and a map server over wireless networks. The data server receives geographic location information from the client devices, indicating a geographic location of each client device, and relays the geographic location information to the client devices in real time via the asynchronous data connections. The map server provides map data to the client devices as requested from the client devices via the synchronous data connections. The geographic location information may be overlaid onto the map data and displayed on any of the client mobile devices to indicate the various locations of the various client devices in real time.

Abstract: A network and method to establish a real-time location based service for client mobile device users. Asynchronous data connections are established between client mobile devices and a data server over wireless networks. Synchronous data connections are established between the client devices and a map server over wireless networks. The data server receives geographic location information from the client devices, indicating a geographic location of each client device, and relays the geographic location information to the client devices in real time via the asynchronous data connections. The map server provides map data to the client devices as requested from the client devices via the synchronous data connections. The geographic location information may be overlaid onto the map data and displayed on any of the client mobile devices to indicate the various locations of the various client devices in real time.