Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: A urinary catheter package with a case having a hollow tube which is closed at one end and open at the other end, the hollow tube having a wall and a pierceable cover attached to the open end of the hollow tube. Also an assembly including the urinary catheter package and a catheter with a funnel at a first end.

Abstract: An integrated energy system includes a nuclear thermal plant situated on a nuclear site. The nuclear thermal plant produces thermal energy that is transported to a thermal energy storage system located outside the nuclear site. The thermal storage system is thermally coupled to a power generation system which is also remote to the nuclear site. By this arrangement, the nuclear thermal plant is isolated and decoupled from the power generation system. The nuclear thermal plant may supply thermal energy upwards of 800° C. or more to be stored at the thermal energy storage system until needed such as for industrial heat, power generation, or other uses. The thermal storage system is source agnostic, and one or more additional thermal energy generators, such as additional nuclear reactors, solar thermal plants, or other thermal energy generators can be coupled to a common thermal storage system and power generation system.

Abstract: A method of moderating concentration of at least highly fluorinated alkyl materials from a contaminated aqueous feed liquid containing an original composition of between 60 parts per trillion and 300 parts per billion of the at least highly fluorinated materials per liter of water into an aqueous electronic separator having at least three chambers including a feed chamber having a liquid exit port from which a mediated aqueous contaminated feed liquid exits and a liquid input port into which the contaminated aqueous feed liquid enters the feed chamber; an anodic electrode chamber filled with an aqueous anodic liquid; and a cathodic electrode chamber filled with an aqueous cathodic liquid; wherein the feed chamber is between and adjacent to the anodic electrode chamber and the cathodic electrode chamber and the feed chamber is separated from each of the anodic electrode chamber and the cathodic electrode chamber by at least one semipermeable membrane.

Abstract: Systems and methods are described to determine whether a sample transmitted through a transfer line from a remote sampling system contains a suitable sample to analyze by an analysis system. A system embodiment includes, but is not limited to, a sample receiving line configured to receive a liquid segment a first detector configured to detect the liquid segment at a first location in the sample receiving line; a second detector configured to detect the liquid segment at a second location in the sample receiving line downstream from the first location; and a controller configured to register a continuous liquid segment in the sample receiving line when the first detector and the second detector match detection states prior to the controller registering a change of state of the first detector.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK or other kinase inhibitor.

Abstract: A straight edge guide system is presented that makes clamping of a workpiece faster and easier. The straight edge guide system includes a guide member that extends a length from a first end to a second end. A clamp member is connected to the first end of the guide member and includes a compressible bias member therein. An adjustable stop member is connected to the guide member that moves between a locked position and a free position. When the adjustable stop member is in the free position, the adjustable stop member slides along the length of the guide member. When the straight edge guide system is placed on top of a workpiece, the workpiece is clamped under spring bias force between the clamp member and the stop member.

Abstract: In various embodiments, a surgical stapling instrument can include a handle, a shaft extending from the handle, wherein the shaft defines an axis, and a disposable loading unit which is assembled to the shaft in a direction which is transverse to the shaft axis. Such a connection between the disposable loading unit and the shaft can prevent, or at least inhibit, the disposable loading unit from being unintentionally displaced proximally and/or distally relative to the shaft of the surgical instrument. The surgical stapling instrument and/or disposable loading unit can further include a threaded collar and/or detent assembly configured to hold the disposable loading unit in place. In various embodiments, a disposable loading unit can include a lockout feature which can prevent, or at least inhibit, an expended disposable loading unit from being reassembled to the elongated body of the surgical instrument.

Abstract: An input device comprising a processor(s), an input element, an electropermanent magnet (EPM) assembly including: a permanent magnet operable to generate a magnetic field; and a magnetizing assembly configured to set a magnetic field generated by the permanent magnet, a first ferromagnetic element, and a second ferromagnetic element. The first ferromagnetic element is configured to part and move away from the second ferromagnetic element as the input element is depressed. When the EPM assembly magnetizes the permanent magnet to a first polarity, the first and second ferromagnetic elements are magnetically attracted to each other and provide an attracting that magnetically opposes the first and second ferromagnetic elements from parting, and when the EPM assembly magnetizes the permanent magnet to a second polarity, the first and second ferromagnetic elements are not magnetically attracted to each other and do not magnetically oppose the first and second ferromagnetic elements from parting.

Abstract: A method of forming a plurality of lipid bilayers over an array of cells in a nanopore based sequencing chip is disclosed. Each of the cells comprises a well. A salt buffer solution is flowed over the array of cells in the nanopore based sequencing chip to substantially fill the wells in the cells with the salt buffer solution. A lipid and solvent mixture is flowed over the array of cells to deposit the lipid and solvent mixture over at least some of the wells in the cells. A first portion of the cells, each having a lipid bilayer over its well, is detected. A second portion of the cells, each having a lipid membrane but not a lipid bilayer over its well, is detected. An electrical lipid-thinning stimulus is selectively applied to the second portion of the cells but not to the first portion of the cells.

Abstract: Various embodiments are generally directed to utilizing a steganographically encoded image with an offline and/or online verification or authentication protocol. A method for using the steganographic image can include: receiving or utilizing a steganographic image associated with a user at a third-party device, the steganographically encoded image including an identification of a user steganographically encoded with a fingerprint template of the user, and authenticating the user using the steganographically encoded image.

Abstract: A system and method for measuring the quality of data reporting in a given medical study is presented. The instant innovation abstracts all relevant medical literature pertaining to a particular disease and categorizes the data and the study for quality and/or completeness. In an embodiment the instant innovation provides a system for study intake, permits user-determined search optimization, and provides for study data tagging. The innovation automates term inclusion and exclusion, automatically removing duplicates of previously collected study metadata, and then subjects the terms to a real-time sorting algorithm. Statistical analysis is performed upon included and excluded terms, and a representation of geometrical closeness from central tendency of any given data element is computed. The data elements and computed tendencies are reduced to a 2D visual representation and delivered to a user. The user may interact with the 2D visual representation using a device.

Abstract: The present disclosure relates generally to a gaming table system and method that identifies a shuffle event based on one or more of a position of a next eligible virtual card in a plurality of virtual playing cards, a position in the plurality of virtual cards of a shuffle card relative to the position of the next eligible virtual card, a counter value indicating a number of ineligible virtual cards, and a counter value indicating a number of remaining eligible virtual cards and in response to identifying a shuffle event, shuffles the plurality of virtual playing cards to form a shuffled plurality of virtual playing cards for assignment to a plurality of physical playing cards, each physical playing card comprising an on-board power source, microprocessor, memory, and digital display to receive and render a value of a corresponding assigned virtual playing card.

Abstract: Described herein is a polypeptide comprising an immunoglobulin chain variable domain comprising three complementarity determining regions (CDR1-CDR3) and four framework regions, wherein: (a) at least one lysine residue in CDR1, CDR2 and/or CDR3 has been substituted with at least one histidine residue, and/or (b) at least one arginine residue in CDR1, CDR2 and/or CDR3 has been substituted with at least one histidine residue. The polypeptides of this disclosure possess increased intestinal stability relative to a corresponding polypeptide not having the histidine substitutions.

Abstract: Provided are multi-layer bioreactors for growing, maintaining, stimulating, monitoring and testing organoids and tissues derived from or representing hollow organs in organoid chambers. Also provided are uses of those bioreactors in modeling a disease process for monitoring disease progress and/or for assessing a biological effect, such as therapeutic efficacy and/or toxicity, e.g., organotoxicity. Also disclosed are bioreactors comprising organoid chambers that are useful as systems for measuring the volume, pressure, contractility, pump function, or electrophysiology of an organoid chamber as well as systems for controlling the pressure experienced by an organoid or tissue in an organoid chamber.

Abstract: Fiber optic networks, optical network units, and methods of configuring a fiber optic network and an optical network unit using a variable ratio coupler are disclosed. In one embodiment, a fiber optic network includes a feeder optical cable. The first optical network unit and the second optical network unit each includes a variable ratio coupler operable to selectively set a split-ratio among a plurality of split-ratios, and a fiber optic transceiver module. The fiber optic network further includes a first drop cable optically coupling the first optical network unit to the feeder optical cable at a first position, and a second drop cable optically coupling the second optical network unit to the feeder optical cable at a second position. A first split-ratio of the first optical network unit is based on the first position and a second split-ratio of the second optical network unit is based on the second position.

Abstract: For three-dimensional segmentation from two-dimensional intracardiac echocardiography imaging, the three-dimension segmentation is output by a machine-learnt multi-task generator. Rather than the brute force approach of training the generator from 2D ICE images to output a 2D segmentation, the generator is trained from 3D information, such as a sparse ICE volume assembled from the 2D ICE images. Where sufficient ground truth data is not available, computed tomography or magnetic resonance data may be used as the ground truth for the sample sparse ICE volumes. The generator is trained to output both the 3D segmentation and a complete volume (i.e., more voxels represented than in the sparse ICE volume). The 3D segmentation may be further used to project to 2D as an input with an ICE image to another network trained to output a 2D segmentation for the ICE image. Display of the 3D segmentation and/or 2D segmentation may guide ablation of tissue in the patient.

Abstract: Equipotent indolocarbazole-derived analogs of staurosporine identified herein are prepared through C—H borylation chemistry. Functionality resides at C2 and C10 of the indolocarbazole aromatic region. Introducing functionality in this previously inaccessible region does not abrogate kinase activity and is shown to change the selectivity profile.

Abstract: An apparatus includes a shaft assembly, an end effector, and a drive member visualization assembly. The end effector includes a first jaw, a second jaw, a staple cartridge, and a drive member capable of actuating along a firing stroke to fire a plurality of staples out of the staple cartridge or to sever tissue. The drive member visualization assembly provides an electronic indication linked to a physical location of the drive member within the upper jaw and the lower jaw during the firing stroke.