Abstract: Methods and kits for detecting and/or quantitating target proteins in biological samples. In particular, the method comprises capture and immobilization of the target protein, protein denaturation, proteolytic digestion, and analysis using a mass spectrometry-based technique.

Abstract: A method of training a human for a marksmanship task using a training apparatus, and the apparatus therefor. The apparatus senses and records motions within a time window. The method includes sensing and recording motions sensed by the one or more sensors, detecting a synchronization event, analyzing the sensed and recorded motions that were sensed in the time window, comparing the analyzed sensed and recorded motions with a set of desired analyzed motions to generate difference data; and, responsive to the comparing, presenting to the user in the user's field of perception visual feedback indicating one or both the direction and magnitude of deviation from the set of desired analyzed motions. The presenting the visual feedback to the user is essentially instantaneous, e.g., commencing no later than 10 ms (at most 100 ms) after the synchronization event.

Abstract: An infrared radiation-sensitive positive-working imageable element has a substrate and single imageable layer that includes a first polymeric binder having urethane or urea moieties in its backbone. The first polymeric binder is also insoluble in water and soluble in a weakly alkaline solution. This imageable element can be imaged and processed using weakly alkaline processing solutions that are free of silicates and metasilicates, which processing solutions may also be used to “gum” the imaged and developed printing surface.

Abstract: A multi-layer, positive-working lithographic printing plate precursor can be imaged with infrared radiation and processed in a single step using a single processing solution that has a pH greater than 6 and up to about 11. This single processing solution both develops the imaged precursor and provides a protective coating that need not be rinsed off before lithographic printing.

Abstract: A negative-working imageable element has an imageable layer and a topcoat layer that contains a composition that will change color upon exposure to imaging infrared radiation. The imageable element can be imaged and developed on-press to provide images with improved contrast for print-out.

Abstract: Negative-working imageable elements that can be imaged using infrared radiation comprise an imageable layer and a protective overcoat on a hydrophilic substrate. The imageable layer includes an IR-sensitive cyanine dye. The protective overcoat predominantly comprises one or more poly(vinyl alcohol) resins, each of which has a hydrolysis level of 85% or less. The use of this particular overcoat composition used in combination with the IR-sensitive cyanine dye provides improved tolerance to fogging by white light while maintaining desired imaging speed.

Abstract: An imaged and developed element, such as a lithographic printing plate, is provided by infrared radiation imaging of a negative-working imagable element having an outermost imagable layer that includes a free radically polymerizable component, a free radical initiator composition comprising a diaryliodonium borate, and an infrared radiation absorbing compound. The imagable layer also includes a polymeric binder that is represented by the following Structure (I): -(A)w-(A?)w?-??(I) wherein A represents recurring units comprising a pendant reactive vinyl group, A? represents recurring units other than those represented by A, w is from about 1 to about 70 mol %, and w? is from about 30 to about 99 mol %. The imagewise exposed element is developed with a gum to remove only the non-exposed regions. The gum has a pH greater than 7 and up to about 11 and at least 1 weight % of an anionic surfactant.

Abstract: A plurality of negative-working lithographic printing plate precursors is provided in a stack. Each precursor comprises an aluminum-containing substrate having thereon a single imageable layer and an outermost topcoat that has a dry coating weight equal to or less than 1 g/m2. The non-imaging backside of the substrate is free of polymer coatings and has an average surface roughness (Ra) in both longitudinal and width directions greater than 0.15 ?m. In addition, the imageable side of each underlying precursor is arranged in direct contact with the aluminum-containing substrate of the precursor above it without the use of an interleaf paper between the precursors.

Abstract: Negative-working imageable elements can be imaged and processed on-press to provide lithographic printing plates, especially with sulfuric acid-anodized aluminum substrates. These elements have an imageable layer that contains two different polymeric binders, a first polymeric binder that is present a discrete particles, and a second polymeric binder that comprises pendant ethylenically unsaturated groups.

Abstract: An infrared radiation-sensitive positive-working imageable element has a substrate and single imageable layer that includes a first polymeric binder having urethane or urea moieties in its backbone. The first polymeric binder is also insoluble in water and soluble in a weakly alkaline solution. This imageable element can be imaged and processed using weakly alkaline processing solutions that are free of silicates and metasilicates, which processing solutions may also be used to “gum” the imaged and developed printing surface.

Abstract: Negative-working imageable elements can be imaged and processed with water to provide lithographic printing plates. These imageable elements have imageable layers that contain a particulate polymeric binder having polyetheramine side chains. Rapid processing speeds are also possible using water and optional mechanical rubbing means for processing the imaged element.

Abstract: The present invention relates to negative-working imageable elements that can be used for the manufacture of printing plates. These imageable elements can be developed on on-press by the action of a lithographic printing ink used in combination with either water or a fountain solution. The imageable elements comprise an imageable layer that is not removable in water or fountain solution alone. The imageable layer includes a free radically polymerizable compound, a free radical initiator composition, an infrared radiation absorbing compound, and a polymeric binder comprising poly(alkylene oxide) pendant groups, and preferably additionally pendant cyano groups.

Abstract: A negative-working imageable element has an imageable layer and a topcoat layer that contains a composition that will change color upon exposure to imaging infrared radiation. The imageable element can be imaged and developed on-press to provide images with improved contrast for print-out.

Abstract: A negative-working lithographic printing plate precursor can be imaged with infrared radiation and processed in a single step using a single processing solution that has a pH of from about 2 to about 11 and contains an anionic surfactant. This single processing solution both develops the imaged precursor and provides a protective coating that need not be rinsed off before lithographic printing. The lithographic printing plate precursor contains a particulate polymeric binder.

Abstract: An imaged and developed element, such as a lithographic printing plate, is provided by infrared radiation imaging of a negative-working imageable element having an outermost imageable layer that includes an acid generating compound that generates acid upon exposure to imaging infrared radiation, an infrared radiation absorbing compound, an acid activatable crosslinking agent that has acid activatable reactive groups, and a polymeric binder that is capable of undergoing an acid-catalyzed condensation reaction with the crosslinking agent. The imaged element is heated at from about 120 to about 150° C. for up to two minutes, and then developed with a single processing solution to remove only the non-exposed regions and to provide a protective layer prior to lithographic printing.

Abstract: The present invention relates to negative-working imageable elements that can be used for the manufacture of printing plates. These imageable elements can be developed on on-press by the action of a lithographic printing ink used in combination with either water or a fountain solution. The imageable elements comprise an imageable layer that is not removable in water or fountain solution alone. The imageable layer includes a free radically polymerizable compound, a free radical initiator composition, an infrared radiation absorbing compound, and a polymeric binder comprising poly(alkylene oxide) pendant groups, and preferably additionally pendant cyano groups.

Abstract: A method for providing lithographic printing plates is achieved by imaging a lithographic printing plate precursor and processing it with fresh (not reused) samples of a processing solution that both develops and protects the resulting lithographic image. The lithographic printing plate precursors can be either negative-working or positive-working.

Abstract: A multi-layer, positive-working lithographic printing plate precursor can be imaged with infrared radiation and processed in a single step using a single processing solution that has a pH greater than 6 and up to about 11. This single processing solution both develops the imaged precursor and provides a protective coating that need not be rinsed off before lithographic printing.

Abstract: An imaged and developed element, such as a lithographic printing plate, is provided by violet radiation imaging of a negative-working imageable element having an outermost imageable layer that includes a free radically polymerizable component, an initiator composition that provides free radicals upon violet irradiation, a sensitizer, and a polymeric binder having pendant reactive vinyl groups. The element also includes an additive that is represented by the following Structure (II): wherein R1, R2, R3, and R4 are independently hydrogen, or alkyl, alkenyl, cycloalkyl, or aryl groups. The imaged element can be developed using a gum having a pH greater than 6 and up to about 11 and comprising at least 1 weight % of one or more anionic surfactants.

Abstract: An imaged and developed element, such as a lithographic printing plate, is provided by infrared radiation imaging of a negative-working imageable element having an outermost imageable layer that includes a free radically polymerizable component, a free radical initiator composition comprising a diaryliodonium borate, and an infrared radiation absorbing compound. The imageable layer also includes a polymeric binder that is represented by the following Structure (I): -(A)w-(A?)w?-??(I) wherein A represents recurring units comprising a pendant reactive vinyl group, A? represents recurring units other than those represented by A, w is from about 1 to about 70 mol %, and w? is from about 30 to about 99 mol %. The imagewise exposed element is developed with a gum to remove only the non-exposed regions. The gum has a pH greater than 7 and up to about 11 and at least 1 weight % of an anionic surfactant.