Patents by Inventor Kevin B. Sippy

Kevin B. Sippy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20080255203
    Abstract: The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.
    Type: Application
    Filed: December 10, 2007
    Publication date: October 16, 2008
    Applicant: Abbott Laboratories
    Inventors: Chih-Hung Lee, Jianguo Ji, Tao Li, Michael R. Schrimpf, Kevin B. Sippy, Murali Gopalakrishnan
  • AZAADAMANTANE DERIVATIVES AND METHODS OF USE
    Publication number: 20080167336
    Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Application
    Filed: November 5, 2007
    Publication date: July 10, 2008
    Applicant: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Marc Scanio, Lei Shi, Chih-Hung Lee, William H. Bunnelle, Geoff G.Z. Zhang, Paul J. Brackemeyer, Shuang Chen, Rodger F. Henry
  • Pharmaceutical compositions and their methods of use
    Publication number: 20080167286
    Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an ?4?2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
    Type: Application
    Filed: December 10, 2007
    Publication date: July 10, 2008
    Applicant: Abbott Laboratories
    Inventors: Murali Gopalakrishnan, Marie P. Honore, Chih-Hung Lee, John Malysz, Jianguo Ji, Tao Li, Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson
  • Amino-Substituted Tricyclic Derivatives and Methods of Use
    Publication number: 20080161281
    Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by ?7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
    Type: Application
    Filed: March 12, 2008
    Publication date: July 3, 2008
    Applicant: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, Jianguo Ji, Tao Li, Jennifer M. Frost, Clark A. Briggs, William H. Bunnelle
  • SPIROCYCLIC AZAADAMANTANE DERIVATIVES AND METHODS OF USE
    Publication number: 20080153860
    Abstract: The invention relates to compounds that are spirocyclic azaadamantane derivatives derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 26, 2008
    Applicant: Abbott Laboratories
    Inventors: Jianguo Ji, Michael R. Schrimpf, Kevin B. Sippy, Tao Li, Chih-Hung Lee
  • Amino-substituted tricyclic derivatives and methods of use
    Patent number: 7365193
    Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by ?7nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: April 29, 2008
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, Jianguo Ji, Tao Li, Jennifer M. Frost, Clark A. Briggs, William H. Bunnelle
  • Heterocyclic substituted aminoazacycles useful as central nervous system agents
    Patent number: 7332504
    Abstract: Heterocyclic substituted aminoazacyclic compounds of formula I Z-R3I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: February 19, 2008
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, Jerome F. Daanen, Keith Brian Ryther, Jianguo Ji
  • Diazabicyclic central nervous system active agents
    Patent number: 7319106
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: January 15, 2008
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Diazabicyclic CNS active agents
    Patent number: 7265115
    Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: September 4, 2007
    Assignee: Abbott Laboratories
    Inventors: William H. Bunnelle, Daniela Barlocco Cristina, Jerome F. Daanen, Michael J. Dart, Michael D. Meyer, Keith B. Ryther, Michael R. Schrimpf, Kevin B. Sippy, Richard B. Toupence
  • Heterocycle substituted aminoazacycles useful as central nervous system agents
    Patent number: 6833370
    Abstract: Heterocyclic substituted aminoazacyclic compounds of formula I Z—R3  I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: December 21, 2004
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, Jerome F. Daanen, Keith Brian Ryther, Jianguo Ji
  • Diazabicyclic central nervous system active agents
    Patent number: 6809105
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: October 26, 2004
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Diazabicyclic central nervous system active agents
    Publication number: 20040186107
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: March 26, 2004
    Publication date: September 23, 2004
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Diazabicyclic CNS active agents
    Publication number: 20030225268
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: April 11, 2003
    Publication date: December 4, 2003
    Inventors: William H. Bunnelle, Daniela Barlocco Cristina, Jerome F. Daanen, Michael J. Dart, Michael D. Meyer, Keith B. Ryther, Michael R. Schrimpf, Kevin B. Sippy, Richard B. Toupence
  • Diazabicyclic central nervous system active agents
    Publication number: 20020019388
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: April 12, 2001
    Publication date: February 14, 2002
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Bicyclic substituted hexahydrobenz ?e! isoindole alpha-1 adrenergic antagonists
    Patent number: 5792767
    Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 11, 1998
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, James F. Kerwin, Jr., Suzanne A. Lebold, Edmund L. Lee, John K. Pratt, Kevin B. Sippy, Karin R. Tietje, Diane M. Yamamoto
  • Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists
    Patent number: 5597823
    Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 28, 1997
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, Steven W. Elmore, James F. Kerwin, Jr., Suzanne A. Lebold, Edmund L. Lee, Kevin B. Sippy, Karin R. Tietje, Michael D. Wendt
  • Bicyclic substituted hexahydrobenz[e]isoindole .alpha.-1 adrenergic antagonists
    Patent number: 5521181
    Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: May 28, 1996
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, Robert J. Altenbach, William A. Carroll, Irene Drizin, Suzanne A. Lebold, Edmund L. Lee, Kevin B. Sippy, Karin R. Tietje, Diane M. Yamamoto, James F. Kerwin, Jr.
  • Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors
    Patent number: 5288749
    Abstract: The present invention provides tertiary and secondary amine compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof which are antagonists for alpha-2 adrenoreceptors and which inhibit serotonin (5-hydroxytryptamine, 5-HT) uptake.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: February 22, 1994
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, John F. DeBernardis, Rajnandan Prasad, Kevin B. Sippy, Karin R. Tietje
  • 5-HT selective agents
    Patent number: 5244888
    Abstract: Substituted 8-alkoxy-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrroles; 5-alkoxy-2,3,4,4a,9,9a-hexahydro-1-H-indeno[2,1-c]pyridines; and 9-alkoxy-2,3,3a,4,5,9a-hexahydro-1H-benz[e]isoindoles are selective 5-HT receptor agents and are thus useful in the treatment of anxiety, depression, and hypertension.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: September 14, 1993
    Assignee: Abbott Laboratories
    Inventors: John F. DeBernardis, Michael D. Meyer, Kevin B. Sippy
  • 5-HT selective agents
    Patent number: 5049564
    Abstract: Substituted 8-alkoxy-1,2,3,3a,8,8a-hexahydroindeno-[1,2-c]pyrroles; 5-alkoxy-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines; and 9-alkoxy-2,3,3a,4,5,9a-hexahydro-1H-benz[e]isoindoles are selective 5-HT receptor agents and are thus useful in the treatment of anxiety, depression, and hypertension.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: September 17, 1991
    Assignee: Abbott Laboratories
    Inventors: John F. DeBernardis, Michael D. Meyer, Kevin B. Sippy