Patents by Inventor Kevin Bacon

Kevin Bacon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9206186
    Abstract: Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: December 8, 2015
    Assignee: AXIKIN PHARMACEUTICALS, INC.
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • Patent number: 9127437
    Abstract: A hydraulic circuit capable of both a regeneration mode of operation and a full force mode of operation includes a poppet valve controlled by a control valve operating in conjunction with a shuttle valve. The opening of the poppet valve enables the regeneration mode of operation, and the closing of the poppet valve enables the full force mode of operation.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: September 8, 2015
    Assignee: Caterpillar Inc.
    Inventors: Timothy Hand, Kevin Bacon, Victor Wen
  • Patent number: 9003786
    Abstract: This disclosure provides for pressure limiting a hydraulic system to a desired pressure value by a particular circuit by controlling and closing the compensator when the desired pressure setting is achieved. Closing the compensator will reduced the pressure head and flow in the circuit resulting in improved efficiency. One illustrated embodiment of the disclosure provides a relief valve in the pilot signal for a compensator. The method relates to limiting the pressure on an open side of the compensator, such that the pressure on the other side closes the compensator thereby limiting the pressure and also flow in the hydraulic circuit. In other words, the pressure on the open side is limited by the relief valve. Thus, the pressure on the other side increases thereby regulating the flow and pressure through the compensator.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: April 14, 2015
    Assignee: Caterpillar Inc.
    Inventors: Kevin A. Bacon, Jason L. Brinkman, Timothy L. Hand, Randall A. Harlow
  • Publication number: 20140026546
    Abstract: A regeneration valve for a hydraulic circuit may include a valve element for controlling flow between first, second, and third ports. The valve element may be formed with a flow slot that generates a slot flow force when hydraulic fluid flows therethrough. The flow slot may be configured so that a predetermined fluid low rate may generate a slot flow force sufficient to actuate the valve element from a first position to a second position. In the second position, the valve element may divert a portion of flow from the second port to the first port is diverted to the third port. The flow slot may be configured so that the fluid exits the slot at an exit angle that varies as the valve element moves between first and second positions, thereby to provide a more uniform flow force across the range of travel of the valve element.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 30, 2014
    Applicant: CATERPILLAR, INC.
    Inventors: Kevin A. Bacon, Gang Victor Wen, Wesley Thomas Payne
  • Publication number: 20140005176
    Abstract: Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
    Type: Application
    Filed: August 26, 2013
    Publication date: January 2, 2014
    Applicant: AXIKIN PHARMACEUTICALS, INC.
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • Publication number: 20120285158
    Abstract: This disclosure provides for pressure limiting a hydraulic system to a desired pressure value by a particular circuit by controlling and closing the compensator when the desired pressure setting is achieved. Closing the compensator will reduced the pressure head and flow in the circuit resulting in improved efficiency. One illustrated embodiment of the disclosure provides a relief valve in the pilot signal for a compensator. The method relates to limiting the pressure on an open side of the compensator, such that the pressure on the other side closes the compensator thereby limiting the pressure and also flow in the hydraulic circuit. In other words, the pressure on the open side is limited by the relief valve. Thus, the pressure on the other side increases thereby regulating the flow and pressure through the compensator.
    Type: Application
    Filed: May 10, 2011
    Publication date: November 15, 2012
    Applicant: Caterpillar Inc.
    Inventors: Randall A. Harlow, Timothy L. Hand, Jason L. Brinkman, Kevin A. Bacon
  • Patent number: 8242118
    Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 14, 2012
    Assignee: Axikin Pharmaceuticals Inc.
    Inventors: Yingfu Li, Akihiko Watanabe, Timothy B. Lowinger, Kevin Bacon, Norihiro Kawamura, Takuya Shintani, Tetsuo Kikuchi, Toshiya Moriwaki, Klaus Urbahns, Keiko Fukushima, Noriko Nunami, Takashi Yoshino, Toshiki Murata, Megumi Yamauchi, Hiroko Yoshino
  • Publication number: 20120152107
    Abstract: A hydraulic circuit capable of both a regeneration mode of operation and a full force mode of operation includes a poppet valve controlled by a control valve operating in conjunction with a shuttle valve. The opening of the poppet valve enables the regeneration mode of operation, and the closing of the poppet valve enables the full force mode of operation.
    Type: Application
    Filed: December 6, 2011
    Publication date: June 21, 2012
    Applicant: Caterpillar Inc.
    Inventors: Timothy Hand, Kevin Bacon, Victor Wen
  • Patent number: 8129386
    Abstract: The present invention relates to novel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (PI3K) inhibition, especially for PI3K-? inhibition and can be used for the prophylaxis and treatment of diseases associated with PI3K and particularly with PI3K-? activity. More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoimmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: March 6, 2012
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Mitsuyuki Shimada, Toshiki Murata, Kinji Fuchikami, Hideki Jishita, Naoki Omori, Issei Kato, Mami Miura, Klaus Urbahns, Florian Gantner, Kevin Bacon
  • Patent number: 7960393
    Abstract: The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: June 14, 2011
    Assignee: Actimis Pharmaceuticals, Inc.
    Inventors: Tai-wei Ly, Yuji Koriyama, Takashi Yoshino, Hiroki Sato, Kazuho Tanaka, Hiromi Sugimoto, Yoshihisa Manabe, Kevin Bacon, Klaus Urbahns, Masanori Seki, Takuya Shintani
  • Publication number: 20110015248
    Abstract: The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.
    Type: Application
    Filed: January 8, 2009
    Publication date: January 20, 2011
    Applicant: INTERMED DISCOVERY GMBH
    Inventors: Marc STADLER, Stephan Seip, Hartwig Müller, Anke Mayer-Bartschmid, Michael-Alexander Brüning, Jordi Benet-Buchholz, Hiroko Togame, Reiko Dodo, Peter Reinemer, Kevin Bacon, Kinji Fuchikami, Satoko Matsukawa, Klaus Urbahns
  • Publication number: 20100322980
    Abstract: The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
    Type: Application
    Filed: August 25, 2010
    Publication date: December 23, 2010
    Inventors: Tai-wei Ly, Yuji Koriyama, Takashi Yoshino, Hiroki Sato, Kazuho Tanaka, Hiromi Sugimoto, Yoshihisa Manabe, Kevin Bacon, Klaus Urbahns, Masanori Seki, Takuya Shintani
  • Patent number: 7829685
    Abstract: Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma, cancer, and diseases in which cell signaling is defective.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: November 9, 2010
    Assignee: Axikin Pharmaceuticals, Inc.
    Inventors: Shinichi Watanabe, Jeffrey A. Encinas, Shinichi Kondo, Kevin Bacon
  • Patent number: 7812160
    Abstract: The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: October 12, 2010
    Assignee: Actimis Pharmaceuticals, Inc.
    Inventors: Tai-wei Ly, Yuji Koriyama, Takashi Yoshino, Hiroki Sato, Kazuho Tanaka, Hiromi Sugimoto, Yoshihisa Manabe, Kevin Bacon, Klaus Urbahns, Masanori Seki, Takuya Shintani
  • Patent number: 7797934
    Abstract: A hydraulic control system for a machine is disclosed. The hydraulic control system may have a source driven by an engine to pressurize fluid, and a tool actuator movable by pressurized fluid. The hydraulic control system may further have a first valve element movable to control an amount of pressurized fluid directed to the tool actuator, and an interface device movable by an operator to control an amount of pressurized fluid directed to move the first valve element. The hydraulic control system may also have a second valve element movable to limit an amount of pressurized fluid available to move the first valve element, and a controller in communication with the second valve element. The controller may be configured to move the second valve element to reduce pressurized fluid directed to the first valve element in an amount related to a load on the engine.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: September 21, 2010
    Assignee: Caterpillar Inc
    Inventors: Kevin A. Bacon, Andrew J. Smith
  • Publication number: 20100204213
    Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 12, 2010
    Inventors: Yingfu LI, Akihiko Watanabe, Timothy B. Lowinger, Kevin Bacon, Norihiro Kawamura, Takuya Shintani, Tetsuo Kikuchi, Toshiya Moriwaki, Klaus Urbahns, Keiko Eukushima, Noriko Nunami, Takashi Yoshino, Toshiki Murata, Megumi Yamauchi, Hiroko Yoshino
  • Patent number: 7750014
    Abstract: The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: July 6, 2010
    Assignee: Actimis Pharmaceuticals, Inc.
    Inventors: Tai-Wei Ly, Takashi Yoshino, Yuki Takekawa, Takuya Shintani, Hiromi Sugimoto, Kevin Bacon, Klaus Urbahns
  • Patent number: 7700586
    Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: April 20, 2010
    Assignee: Axikin Pharmaceuticals, Inc.
    Inventors: Yingfu Li, Akihiko Watanabe, Timothy B. Lowinger, Kevin Bacon, Norihiro Kawamura, Takuya Shintani, Tetsuo Kikuchi, Toshiya Moriwaki, Klaus Urbahns, Keiko Fukushima, Noriko Nunami, Takashi Yoshino, Toshiki Murata, Megumi Yamauchi, Hiroko Yoshino
  • Patent number: 7674797
    Abstract: The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: March 9, 2010
    Assignee: Axikin Pharmaceuticals, Inc.
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • Publication number: 20090286771
    Abstract: Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
    Type: Application
    Filed: July 16, 2009
    Publication date: November 19, 2009
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida