Abstract: An automated apparatus can provide pre-analytical processing of samples, racking and forwarding to an adjacent analyzer for analysis. The apparatus may have a controller that implements an auto-learn process to teach robotic handlers the locations within the workspace(s) of the apparatus. A robotic sample handler may include a sensor configured to generate a detection signal when in a near vicinity of a fiducial beacon in the workspace of the apparatus for biological sample preparation, preprocessing and/or diagnostic assay performed by one or more analyzers of the automated apparatus. The controller may control the robotic sample handler to conduct a search pattern so that a location of the fiducial beacon may be detected and thereafter calculated to obtain a more accurate location of the beacon. The calculated positions may then serve as a basis for the controlled movement of samples by the robot to and from locations of the workspace.

Abstract: Provided herein are compounds that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).

Abstract: A rejuvenation and massage device is provided for treating mucosa tissue, such as vaginal tissue, affected by Vaginal Relaxation Syndrome (VRS) or other conditions, through vibration, thermal loading, and light emittance for a duration of time. In one embodiment, the device is an insertable device that includes Low-Level Laser Light (LLLT) therapy to treat the vaginal tissue. The light emittance by one or more light emitters is in a range sufficient to provide therapeutic effects through light radiation. To enhance the therapeutic effects of light radiation provided by the device, the device is configured to provide increased energy density into target tissue of vaginal muscles though a light configuration component (e.g., a focusing component, such as a concave lens assembly, a convex assembly, a pre-lensed light emitter or other focusing optical mechanism) associated with the light emitter that concentrates the light emitted from the light emitter.

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract: A rejuvenation and massage device is provided for treating mucosa tissue, such as vaginal tissue, affected by Vaginal Relaxation Syndrome (VRS) or other conditions, through vibration, thermal loading, and light emittance for a duration of time. In one embodiment, the device is an insertable device that includes Low-Level Laser Light (LLLT) therapy to treat the vaginal tissue. The light emittance by one or more light emitters is in a range sufficient to provide therapeutic effects through light radiation. To enhance the therapeutic effects of light radiation provided by the device, the device is configured to provide increased energy density into target tissue of vaginal muscles though a light configuration component (e.g., a focusing component, such as a concave lens assembly, a convex assembly, a pre-lensed light emitter or other focusing optical mechanism) associated with the light emitter that concentrates the light emitted from the light emitter.

Abstract: An example sexual stimulation device includes a drive module, a stimulating element, a fulcrum, and a compliant member. The stimulating element has a first end coupled to the drive module in a manner such that the first end of the stimulating element moves along a first path when the drive module is operated. The stimulating element also has a second end opposite the first end. The fulcrum is disposed at a first point along an extension of the stimulating element such that the stimulating element pivots about the first point and the second end of the stimulating element translates according to a second path. The compliant member is coupled to the second end of the stimulating element.

Abstract: A core body includes a structure having a plurality of connected unit cells. At least one unit cell has one or more sidewalls that are curved and define a portion of an inner passageway within and through the unit cell. The one or more sidewalls define multiple orifices and include a cone disposed between at least some of the orifices. A dimple is defined along an outer surface of the unit cell at the cone. The outer surface at least partially defines an outer passageway that is sealed from the inner passageway by the one or more sidewalls. The one or more sidewalls are configured to transport one or more of thermal energy from a first fluid or a component of the first fluid flowing in the inner passageway to a second fluid flowing in the outer passageway without the first fluid mixing with the second fluid.

Abstract: An infant sleep device may include a platform for supporting an infant, a base upon which the platform is supported, and one or more weight sensors positioned to measure weight of an infant positioned on the platform.

Abstract: An alignment system includes an optical sensor device that may be inserted into a passage of a body that is located between a fuel injector and a combustion chamber of an engine cylinder. The body is shaped to transmit fuel ejected from a spray hole in a fuel injector into the combustion chamber of the engine cylinder. The system also includes a controller that may examine output of the optical sensor device and determine whether the passage of the body is aligned with the spray hole of the fuel injector based on the output from the optical sensor device. The controller may change a position of one or more of the body or the fuel injector responsive to determining that the passage of the body is not aligned with the spray hole of the fuel injector.

Abstract: A core body includes a structure having a plurality of connected unit cells. At least one unit cell has one or more sidewalls that are curved and define a portion of an inner passageway within and through the unit cell. The one or more sidewalls define multiple orifices and include a cone disposed between at least some of the orifices. A dimple is defined along an outer surface of the unit cell at the cone. The outer surface at least partially defines an outer passageway that is sealed from the inner passageway by the one or more sidewalls. The one or more sidewalls are configured to transport one or more of thermal energy from a first fluid or a component of the first fluid flowing in the inner passageway to a second fluid flowing in the outer passageway without the first fluid mixing with the second fluid.

Abstract: A shared storage system that is optimized for post-production workflows that use NLEs such as Final Cut Pro X, DaVinci Resolve, Premiere and Avid is disclosed. Further, shared storage systems comprising workstations and shared storage systems, such as NAS devices, are disclosed that optimize workstation settings based on a database of optimal configuration settings to provide optimal bandwidth, minimal latency and stable performance for digital content creation/editing workflows that use file exchange between the workstation and the shared storage system. Novel methods and systems for storage systems are disclosed that configure and expose share drives in novel ways to facilitate video editing, audio editing and compositing.

Abstract: An infant sleep device may include a platform for supporting an infant, a base upon which the platform is supported, and one or more weight sensors positioned to measure weight of an infant positioned on the platform.

Abstract: A mixing structure can include a body having first conduits, mixture conduits, and second conduits extending through the body to the internal volume. The first conduits may be closer to a first side of the body than the mixture conduits and the second conduits. The second conduits may closer to another side of the body than the first conduits and the mixture conduits. The internal volume may receive liquid streams from an injector. The first conduits and the second conduits may receive gas streams from outside the body. The body may thermally modify the gas streams and entrain the gas streams into the liquid streams in the internal volume. The mixture conduits may be positioned to direct the gas streams entrained into the liquid streams out of the body in directions directed toward the second side of the body and away from the first side of the body.

Abstract: A fuel and gas mixing structure for an engine is provided. This mixing structure includes a body configured to be positioned between a fuel injector and a cylinder of an engine. The body defines an interior volume that is configured to receive gas (e.g., air) from outside the body and to receive one or more streams of fuel from the fuel injector in the interior volume. The body also includes one or more upper channels and one or more lower channels that are configured to provide a substantially similar amount of flow relative to each other to the interior volume The body also defines one or more mixture conduits configured to conduct plumes of the fuel and gas, while mixing, from the interior volume to one or more exit ports and therethrough to the cylinder.

Abstract: A pierceable cap 11 may be used for containing sample specimens. The pierceable cap 11 may prevent escape of sample specimens before transfer with a transfer device 43. The pierceable cap 11 may fit over a vessel 21. An access port in the shell of the pierceable cap 11 may allow passage of a transfer device 43 through the pierceable cap 11. At least one frangible layer 215, 216 may be configured with cross slits 506 in a particular cross slit geometry. The cross slits 506 may contain an openable portion 644 or be covered by a thin membrane 645. The shell 610 and frangible layer(s) 215, 216 may be integrated into a one piece cap 601, or be separate components 634. The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device 43 to the cross slits 506.

Abstract: A shared storage system that is optimized for post-production workflows that use NLEs such as Final Cut Pro X, DaVinci Resolve, Premiere and Avid is disclosed. Further, shared storage systems comprising workstations and shared storage systems, such as NAS devices, are disclosed that optimize workstation settings based on a database of optimal configuration settings to provide optimal bandwidth, minimal latency and stable performance for digital content creation/editing workflows that use file exchange between the workstation and the shared storage system. Novel methods and systems for storage systems are disclosed that configure and expose share drives in novel ways to facilitate video editing, audio editing and compositing.

Abstract: A core body includes a structure having a plurality of connected unit cells. At least one unit cell has one or more sidewalls that are curved and define a portion of an inner passageway within and through the unit cell. The one or more sidewalls define multiple orifices and include a cone disposed between at least some of the orifices. A dimple is defined along an outer surface of the unit cell at the cone. The outer surface at least partially defines an outer passageway that is sealed from the inner passageway by the one or more sidewalls. The one or more sidewalls are configured to transport one or more of thermal energy from a first fluid or a component of the first fluid flowing in the inner passageway to a second fluid flowing in the outer passageway without the first fluid mixing with the second fluid.

Abstract: A braille cell and associated braille pin support and pin actuation assemblies are disclosed. The braille cell can include a frame, braille pins movable up and down between raised and lowered positions, and a pin actuation assembly to individually move the pins. The braille cell can include support arms, each of which having a base end connected to the frame and a pin end connected to and following a motion of a respective pin between its raised and lowered positions. The pin actuation assembly can include pin actuation units, each having a motor with a rotatable motor shaft and multiple cams mounted on the shaft, each for selectively actuating a respective pin. Each pin actuation unit can also include an angular position sensing system for monitoring, for example magnetically, a passage of the shaft through a reference angular position, and deriving information about a current angular position of the shaft.

Abstract: An alignment system includes an optical sensor device that may be inserted into a passage of a body that is located between a fuel injector and a combustion chamber of an engine cylinder. The body is shaped to transmit fuel ejected from a spray hole in a fuel injector into the combustion chamber of the engine cylinder. The system also includes a controller that may examine output of the optical sensor device and determine whether the passage of the body is aligned with the spray hole of the fuel injector based on the output from the optical sensor device. The controller may change a position of one or more of the body or the fuel injector responsive to determining that the passage of the body is not aligned with the spray hole of the fuel injector.

Abstract: A pierceable cap 11 may be used for containing sample specimens. The pierceable cap 11 may prevent escape of sample specimens before transfer with a transfer device 43. The pierceable cap 11 may fit over a vessel 21. An access port in the shell of the pierceable cap 11 may allow passage of a transfer device 43 through the pierceable cap 11. At least one frangible layer 215, 216 may be configured with cross slits 506 in a particular cross slit geometry. The cross slits 506 may contain an openable portion 644 or be covered by a thin membrane 645. The shell 610 and frangible layer(s) 215, 216 may be integrated into a one piece cap 601, or be separate components 634. The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device 43 to the cross slits 506.