Abstract: Provided herein are antagonists of prostaglandin EP3 receptor, processes to make said antagonists, and methods comprising administering said antagonists to a mammal in need thereof.

Abstract: The inventive body care device having a handle and a treatment head, which is hingedly connected mechanically therewith, has a flexible zone for enabling an elastic deflection of the treatment head with respect to the handle and a deflection sensor, which is capable of generating an electric signal as a function of the elastic deflection. This signal can be used to control an automatic start and/or stop function, a use counter and/or operating states of an electric vibrational element integrated in the body care device.

Abstract: Pop-up dispensing systems for dispensing substantially dry wipes while minimizing “clumping” and “fallbacks”, or sticking of tacky, adhesive binder loaded wipes within the interior of the container body. The dispensing system includes a container having a container body forming an interior region, and a plurality of stacked substantially dry wipes or other substrates. The wipes may be loaded with an adhesive binder or other material. By selecting and providing particular characteristics relative to the cross-sectional area of the dispensing orifice (e.g., 22 cm2 to 75 cm2) and the separation force profile (e.g., 1 gf/cm2 to 6 gf/cm2), wipes which are loaded with an adhesive, tacky binder material can be dispensed one at a time, while minimizing clumping and fallbacks, and any tendency of the wipes to becoming stuck within the container body.

Abstract: Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of at least about 45 ?m within the article are provided. In one embodiment, the compressive stress profile includes a single linear segment extending from the surface to the depth of compression DOC. Alternatively, the compressive stress profile includes two linear portions: the first portion extending from the surface to a relatively shallow depth and having a steep slope; and a second portion extending from the shallow depth to the depth of compression. Methods of achieving such stress profiles are also described.

Abstract: Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of layer DOL of about 130 ?m up to about 175 ?m or, alternatively, to a depth of compression (DOC) in a range from about 90 ?m to about 120 ?m within the article. The compressive layer has a stress profile that includes a first substantially linear portion extending from a relatively shallow depth to the DOL or DOC and a second portion extending from the surface to the shallow depth. The second portion is substantially linear at a depth from 0 ?m to 5 ?m and has a steeper slope than that of the first portion of the profile. Methods of achieving such stress profiles are also described.

Abstract: The inventive body care device having a handle and a treatment head, which is hingedly connected mechanically therewith, has a flexible zone for enabling an elastic deflection of the treatment head with respect to the handle and a deflection sensor, which is capable of generating an electric signal as a function of the elastic deflection. This signal can be used to control an automatic start and/or stop function, a use counter and/or operating states of an electric vibrational element integrated in the body care device.

Abstract: Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of at least about 45 ?m within the article are provided. In one embodiment, the compressive stress profile includes a single linear segment extending from the surface to the depth of compression DOC. Alternatively, the compressive stress profile includes two linear portions: the first portion extending from the surface to a relatively shallow depth and having a steep slope; and a second portion extending from the shallow depth to the depth of compression. The strengthened glass has a 60% survival rate when dropped from a height of 80 cm in an inverted ball drop test and an equibiaxial flexural strength of at least 10 kgf as determined by abraded ring-on-ring testing. Methods of achieving such stress profiles are also described.

Abstract: Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of at least about 45 ?m within the article are provided. In one embodiment, the compressive stress profile includes a single linear segment extending from the surface to the depth of compression DOC. Alternatively, the compressive stress profile includes two linear portions: the first portion extending from the surface to a relatively shallow depth and having a steep slope; and a second portion extending from the shallow depth to the depth of compression. The strengthened glass has a 60% survival rate when dropped from a height of 80 cm in an inverted ball drop test and an equibiaxial flexural strength of at least 10 kgf as determined by abraded ring-on-ring testing. Methods of achieving such stress profiles are also described.

Abstract: Provided herein are antagonists of prostaglandin EP3 receptor, processes to make said antagonists, and methods comprising administering said antagonists to a mammal in need thereof.

Abstract: Embodiments of a layered-substrate comprising a substrate and a layer disposed thereon, wherein the layered-substrate is able to withstand fracture when assembled with a device that is dropped from a height of at least 100 cm onto a drop surface, are disclosed. The layered-substrate may exhibit a hardness of at least about 10 GPa or at least about 20 GPa. The substrate may include an amorphous substrate or a crystalline substrate. Examples of amorphous substrates include glass, which is optionally chemically strengthened. Examples of crystalline substrates include single crystal substrates (e.g. sapphire) and glass ceramics. Articles and/or devices including such layered-substrate and methods for making such devices are also disclosed.

Abstract: Heterogeneous sensors simultaneously inspect network traffic for attacks. A signature-based sensor detects known attacks but has a blind spot, and a machine-learning based sensor that has been trained to detect attacks in the blind spot detects attacks that fail to conform to normal network traffic. False positive rates of the machine-learning based sensor are reduced by iterative testing using statistical techniques.

Abstract: Embodiments are directed to strengthened glass articles comprising a thickness t?1 mm (1000 ?m), an inner region under a central tension CT (in MPa), and at least one compressive stress layer adjacent the inner region and extending within the strengthened glass article from a surface of the strengthened glass article to a depth of layer DOL (in ?m), wherein the strengthened glass article is under a compressive stress at the surface CSs (in MPa), wherein the strengthened glass article is an alkali aluminosilicate glass article comprising 0-5 mol % Li2O, and at least 3 mol % Al2O3, and wherein the DOL?70 ?m, and a CSs/DOL ratio?2.5 MPa/?m.

Abstract: Heterogeneous sensors simultaneously inspect network traffic for attacks. A signature-based sensor detects known attacks but has a blind spot, and a machine-learning based sensor that has been trained to detect attacks in the blind spot detects attacks that fail to conform to normal network traffic. False positive rates of the machine-learning based sensor are reduced by iterative testing using statistical techniques.

Abstract: The thaw indicator is a device to determine if a frozen space has gone thru an undesired temperature change and if so remains in an alert position until manually reset even if the temperature corrects itself. It's made up of three major components a base, a piston indicator and a transparent tube. When frozen the thaw indicator looks like a thermometer when unfrozen it looks like a thermometer that has jumped out of its case indicating a change of temperature and state with great certainty. It has been designed to stay out of the way but in plain sight.

Abstract: Heterogeneous sensors simultaneously inspect network traffic for attacks. A signature-based sensor detects known attacks but has a blind spot, and a machine-learning based sensor that has been trained to detect attacks in the blind spot detects attacks that fail to conform to normal network traffic. False positive rates of the machine-learning based sensor are reduced by iterative testing using statistical techniques.

Abstract: A comminuting device for comminuting material. The device has a frame and a shear member having a main blade, the shear member movably coupled to the frame with a shear member slide bearing located at least partially inside the frame. A supporting table is coupled to the frame, the supporting table having a counter blade, the supporting table adapted to support the scrap material. The frame has an opening forming an access way to the shear member slide bearing. The main blade and the counter blade cooperate to chop the scrap material when the shear member is moved from a first position to a second position. The shear member slide bearing is removable from inside the frame through the opening without removal of the shear member from the frame.

Abstract: A recycling machine deflection detection system including a cross head movable within a shear box of a recycling machine, one or more sensor units disposed on the cross head, and a controller connected to the one or more sensor units, the controller being configured to receive deflection signals from the one or more sensor units and determine, from the deflection signals, a shear deflection angle of the cross head due to deformation of the cross head.

Abstract: The inventive body care device having a handle and a treatment head, which is hingedly connected mechanically therewith, has a flexible zone for enabling an elastic deflection of the treatment head with respect to the handle and a deflection sensor, which is capable of generating an electric signal as a function of the elastic deflection. This signal can be used to control an automatic start and/or stop function, a use counter and/or operating states of an electric vibrational element integrated in the body care device.

Abstract: A comminuting device for comminuting material. The device has a frame and a shear member having a main blade, the shear member movably coupled to the frame with a shear member slide bearing located at least partially inside the frame. A supporting table is coupled to the frame, the supporting table having a counter blade, the supporting table adapted to support the scrap material. The frame has an opening forming an access way to the shear member slide bearing. The main blade and the counter blade cooperate to chop the scrap material when the shear member is moved from a first position to a second position. The shear member slide bearing is removable from inside the frame through the opening without removal of the shear member from the frame.

Abstract: A charcoal heating material, such as charcoal briquettes, includes a porous structure that facilitates the flow of oxygen about the charcoal, and thereby, enables the briquettes to ignite easily and quickly. In particular the lightweighted charcoal briquettes have a density from about 0.50 grams per cubic centimeter to about 0.80 grams per cubic centimeter. Methods of forming charcoal heating materials include mixing a rheology modifying agent and a moisture phase with a charcoal mixture to facilitate absorption of additional water into the solid matrix, providing increased porosity and lightweighting of the finished briquette after drying.