Abstract: A digital booster for an optical system includes an image acquisition unit. The image acquisition unit is configured to acquire an image frame from a non-magnified optic. The image frame includes an aiming reticle imposed by the non-magnified optic. The digital booster includes a display and a processor. The processor is configured to locate the aiming reticle on the image frame, select a sub-frame of the image frame with an aspect ratio that is centered on the aiming reticle of the image frame, perform image inversion and rescaling of the sub-frame, and transmit the sub-frame to the display.

Abstract: A digital booster for an optical system includes an image acquisition unit. The image acquisition unit is configured to acquire an image frame from a non-magnified optic. The image frame includes an aiming reticle imposed by the non-magnified optic. The digital booster includes a display and a processor. The processor is configured to locate the aiming reticle on the image frame, select a sub-frame of the image frame with an aspect ratio that is centered on the aiming reticle of the image frame, perform image inversion and rescaling of the sub-frame, and transmit the sub-frame to the display.

Abstract: A direct view optical sighting system. In certain examples the system includes an eyepiece, an objective that directs scene light to the eyepiece, a laser rangefinder, and a laser rangefinder coupling prism that directs a laser transmit beam from the laser rangefinder to the objective and a laser return beam from the objective to the laser rangefinder. Examples of the system further include a display assembly including a reticle prism and a display coupling prism, the reticle prism being positioned along the optical path between the laser rangefinder coupling prism and the display coupling prism and having a hard reticle formed on a surface thereof. The objective can be configured to produce a first focal plane of the optical sighting system coincident with the first surface of the reticle prism. The display coupling prism is configured to direct display light toward the eyepiece.

Abstract: The present disclosure provides conjugates of kinase inhibitors and cyanine dyes, as well as related compositions, methods and uses.

Abstract: A direct view optical sighting system. In certain examples the system includes an eyepiece, an objective that directs scene light to the eyepiece, a laser rangefinder, and a laser rangefinder coupling prism that directs a laser transmit beam from the laser rangefinder to the objective and a laser return beam from the objective to the laser rangefinder. Examples of the system further include a display assembly including a reticle prism and a display coupling prism, the reticle prism being positioned along the optical path between the laser rangefinder coupling prism and the display coupling prism and having a hard reticle formed on a surface thereof. The objective can be configured to produce a first focal plane of the optical sighting system coincident with the first surface of the reticle prism. The display coupling prism is configured to direct display light toward the eyepiece.

Abstract: Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.

Abstract: The present disclosure provides conjugates of kinase inhibitors and cyanine dyes, as well as related compositions, methods and uses.

Abstract: A switch assembly is provided for optical sight activation. The switch assembly includes a shoulder mounted device comprising an actuatable portion and a stock, an electrically powered optical sight disposable on the shoulder mounted device in alignment with the actuatable portion, a switch disposed in the stock and actuatable to activate operations of the optical sight and circuitry by which the optical sight and the switch are electrically coupled.

Abstract: A switch assembly is provided for optical sight activation. The switch assembly includes a shoulder mounted device comprising an actuatable portion and a stock, an electrically powered optical sight disposable on the shoulder mounted device in alignment with the actuatable portion, a switch disposed in the stock and actuatable to activate operations of the optical sight and circuitry by which the optical sight and the switch are electrically coupled.

Abstract: Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.

Abstract: A rising stem valve with a magnetic actuator having an outer and as inner magnet assembly that are magnetically coupled to each other so that the inner and outer magnet assemblies rotate together and a ball screw that is connected to the rising stem valve and that converts rotary to reciprocal motion. The inner magnetic cartridge assembly and valve body comprise a sealed lower section that is completely sealed to the outside environment.

Abstract: Monovalent compounds having moieties comprising at least one amino acid side chain are bound to a core molecule, which also comprises a nucleophilic moiety bound to said core molecule. Monovalent compounds also comprise a macrocyclic ring, a nucleophilic moiety, and a spacer group. Monovalent compounds may be combined into bivalent and trivalent compounds, some of which may have a labeling tag. Methods of production of bivalent compounds and contemplated uses thereof are disclosed.

Abstract: Provided herein are compounds and methods of using same for the perturbation and/or inhibition of protein-protein interactions. Also provided herein is a data mining method useful for the identification of protein-protein interactions that may be inhibited by these compounds.

Abstract: A sight mount for use with an electrically powered sight is provided. The sight mount includes a lower portion connectably securable to a mounting surface, an upper portion supportive of the sight and comprising electrodes connectable with sight circuitry and a central portion integrally interposed between the lower and upper portions. The central portion includes a body formed to define a cavity securably receptive of a power supply such that the power supply couples with the electrodes to power the sight.

Abstract: A rotary valve assembly composing a leak-free enclosure containing a worm gear and a pinion gear, an adapter plate that is situated between a rotary valve body and the enclosure and that secures the rotary valve body to the enclosure, and a magnetic actuator assembly. The worm gear engages with the pinion gear such that when the worm gear rotates, the pinion gear rotates as well. The enclosure is situated between the magnetic actuator assembly and the rotary valve body. A shaft extends through the center of the pinion gear and causes a valve within the rotary valve body to open and close based on rotation of the shaft. In an alternate embodiment, the invention is a rotary valve as described above with an integral adapter plate.

Abstract: A rising stem valve with a magnetic actuator having an outer and as inner magnet assembly that are magnetically coupled to each other so that the inner and outer magnet assemblies rotate together aid a ball screw that is connected to the rising stem valve and that converts rotary to reciprocal motion. The inner magnetic cartridge assembly and valve body comprise a sealed lower section that is completely sealed to the outside environment.

Abstract: A polyurethane foam article comprises a first lift, a second lift, and a pass-line therebetween. The polyurethane foam article comprises the reaction product of an isocyanate-reactive resin composition, an isocyanate, and an indicator dye in the presence of a blowing agent. The indicator dye imparts a color in the first and second lifts and at the pass-line at a first temperature below a decomposition temperature of the indicator dye. The indicator dye chemically decomposes to impart a change in color in the first and second lifts and at the pass-line at a second temperature which is at or above the decomposition temperature of the indicator dye.

Abstract: A valve assembly comprising an adapter plate assembly comprising an adapter plate, a bonnet with a center and a threaded shaft extending through the center of the bonnet; an actuation assembly comprising an outer enclosure and an outer magnetic cartridge that is magnetically coupled to an inner magnetic cartridge; and an inner valve assembly comprising an inner enclosure and a planetary gear subassembly comprising one or more planetary gears.

Abstract: Provided herein are compounds and methods of using same for the perturbation and/or inhibition of protein-protein interactions. Also provided herein is a data mining method useful for the identification of protein-protein interactions that may be inhibited by these compounds.

Abstract: A stemless ball valve comprising a first flange, second flange, ball, inner magnetic cartridge, outer magnetic cartridge, and planetary gear assembly. The inner magnetic cartridge is situated inside of the outer magnetic cartridge, and the inner and outer magnetic cartridges actuate the valve. The planetary gear assembly is situated between the inner magnetic cartridge and the ball. The planetary gear assembly comprises one or more planetary gear phases, each planetary gear phase comprising a step-down gear. Each planetary gear phase comprises one or more planetary gears that engage with the inner teeth of the outer ring of the planetary gear assembly and with a step-down gear. The invention further comprises a pressure equalization system comprising inner and outer equalization tubes, a piston situated between the inner and outer equalization tubes, and either a piston spring or spring washer stack that biases the piston in the direction of the clean oil.