Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: An apparatus includes a flywheel, a first pivotable caliper, a first magnet supported by the first caliper opposite the flywheel, a second pivotable caliper and a second magnet supported by the second caliper opposite the flywheel. In one implementation, the apparatus further includes a first cam follower coupled to the first caliper, a second cam follower coupled to the second caliper and at least one cam member including a first cam surface against which the first cam follower moves and a second cam surface against which the second cam follower moves, wherein movement of the at least one cam member pivots the first caliper and the second caliper to move the first magnet and the second magnet relative to the flywheel. In another implementation, the apparatus further includes a strain gauge carried by the first caliper to output signals indicating braking torque.

Abstract: An apparatus includes a flywheel, a first pivotable caliper, a first magnet supported by the first caliper opposite the flywheel, a second pivotable caliper and a second magnet supported by the second caliper opposite the flywheel. In one implementation, the apparatus further includes a first cam follower coupled to the first caliper, a second cam follower coupled to the second caliper and at least one cam member including a first cam surface against which the first cam follower moves and a second cam surface against which the second cam follower moves, wherein movement of the at least one cam member pivots the first caliper and the second caliper to move the first magnet and the second magnet relative to the flywheel. In another implementation, the apparatus further includes a strain gauge carried by the first caliper to output signals indicating braking torque.

Abstract: An exercise bike may include a magnetic braking system to resist rotation of a flywheel. The magnetic braking system may be magnets mounted on brackets selectively pivoted relative to the frame to increase or decrease the resistance opposing rotation of the flywheel. The brackets may be pivoted using a brake adjustment assembly joined to the brackets in such a manner that the magnetic forces resisting rotation of the flywheel increase or decrease in a proportional manner over at least a portion of the adjustment range of the brake adjustment assembly. The exercise bike may further include a console that displays information, such as power. The power may be estimated from a look-up table using the crank or flywheel speed of the exercise bike measured using a speed sensor and the tilt angle of the brackets relative to a reference point measured using a power sensor that includes an accelerometer.

Abstract: An exercise bike may include a magnetic braking system to resist rotation of a flywheel. The magnetic braking system may be magnets mounted on brackets selectively pivoted relative to the frame to increase or decrease the resistance opposing rotation of the flywheel. The brackets may be pivoted using a brake adjustment assembly joined to the brackets in such a manner that the magnetic forces resisting rotation of the flywheel increase or decrease in a proportional manner over at least a portion of the adjustment range of the brake adjustment assembly. The exercise bike may further include a console that displays information, such as power. The power may be estimated from a look-up table using the crank or flywheel speed of the exercise bike measured using a speed sensor and the tilt angle of the brackets relative to a reference point measured using a power sensor that includes an accelerometer.